Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis

scientific article published on 9 January 2013

Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.03307-12
P932PMC publication ID3592145
P698PubMed publication ID23302888
P5875ResearchGate publication ID234098578

P50authorTimothy W PharesQ117769739
Stephen A StohlmanQ117769757
Cornelia C. BergmannQ55426323
P2093author name stringDavid R Hinton
P2860cites workCXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous SystemQ57209761
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesionsQ59070288
Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cellsQ60609607
Antibody-mediated clearance of alphavirus infection from neuronsQ68262671
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's diseaseQ74016859
Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59Q74255036
BAFF is a survival and maturation factor for mouse B cellsQ74456240
Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-gamma but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitroQ81366397
Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitisQ27470828
Molecular and biochemical characterization of a novel gamma-interferon-inducible proteinQ28115640
A chemokine-driven positive feedback loop organizes lymphoid folliclesQ28142202
Regulation of chemokine receptor expression in human microglia and astrocytesQ28181079
APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cellsQ28263864
BCMA is essential for the survival of long-lived bone marrow plasma cellsQ28587037
Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis.Q30229156
RNase L mediated protection from virus induced demyelinationQ33508237
The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system.Q33508816
Monocytes regulate T cell migration through the glia limitans during acute viral encephalitisQ33826812
CXC chemokine ligand (CXCL) 9 and CXCL10 are antagonistic costimulation molecules during the priming of alloreactive T cell effectorsQ33913346
Lymphoid chemokines in the CNS.Q34020894
TNF-alpha-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitisQ34020909
The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1.Q34079019
Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-ArmstrongQ34186024
CXCR3 in T cell functionQ34726782
Factors supporting intrathecal humoral responses following viral encephalomyelitis.Q34742821
Characterization of chemokines and their receptors in the central nervous system: physiopathological implicationsQ34920888
Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responsesQ35057388
Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.Q35077519
CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitisQ35077540
The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous systemQ35104199
Immune responses to RNA-virus infections of the CNS.Q35140815
Homing of antibody secreting cellsQ35170914
Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis.Q35176347
T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating diseaseQ35708880
Chemokines and glial cells: a complex network in the central nervous system.Q35771258
Expression Analysis of the T-Cell-Targeting Chemokines CXCL9 and CXCL10 in Mice and Humans with Endothelial Infections Caused by Rickettsiae of the Spotted Fever GroupQ35792171
CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitisQ35826089
Macrophages induce differentiation of plasma cells through CXCL10/IP-10Q36278025
Biochemical characterization of a gamma interferon-inducible cytokine (IP-10).Q36353962
Coronavirus infection of the central nervous system: host-virus stand-offQ36369843
CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.Q36483798
Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malariaQ36534408
T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous systemQ36829349
Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodiesQ36863593
Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cellsQ36961739
Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.Q36994656
Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity--a tale of conflict and conundrumQ37757179
CXCR3 ligands: redundant, collaborative and antagonistic functionsQ37827339
Pathogenic and physiological autoantibodies in the central nervous systemQ38020957
IL-21 is required to control chronic viral infectionQ39328817
Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system.Q39578252
In Semliki Forest virus encephalitis, antibody rapidly clears infectious virus and is required to eliminate viral material from the brain, but is not required to generate lesions of demyelinationQ39939080
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablastsQ40066472
Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitisQ40173532
The nervous system as ectopic germinal center: CXCL13 and IgG in lyme neuroborreliosisQ40414775
Antibody prevents virus reactivation within the central nervous systemQ41670143
Inverted immunodominance and impaired cytolytic function of CD8+ T cells during viral persistence in the central nervous system.Q41689082
The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic diseaseQ41756177
TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigensQ43596939
Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous systemQ43684853
IFN-gamma secreted by virus-specific CD8+ T cells contribute to CNS viral clearanceQ43897881
Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia.Q43925944
Antibody is required for clearance of infectious murine hepatitis virus A59 from the central nervous system, but not the liver.Q45735071
Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating diseaseQ45756711
Virus specificity and isotype expression of intraparenchymal antibody-secreting cells during Sindbis virus encephalitis in miceQ45777848
Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis.Q45993184
Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation.Q46015831
Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS.Q46023372
Recruitment kinetics and composition of antibody-secreting cells within the central nervous system following viral encephalomyelitisQ46106385
CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS.Q46275246
Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosisQ46423951
IL-21R on T cells is critical for sustained functionality and control of chronic viral infectionQ46697142
Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.Q47357498
Cytokine regulation of CC and CXC chemokine expression by human astrocytesQ48246768
CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampusQ48342001
Functional expression of CXCR3 in cultured mouse and human astrocytes and microgliaQ48573807
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.Q51966554
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells.Q51974964
Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals.Q52950179
Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response.Q52956500
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectastrocyteQ502961
P1104number of pages11
P304page(s)3382-3392
P577publication date2013-01-09
P1433published inJournal of VirologyQ1251128
P1476titleAstrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis
P478volume87

Reverse relations

cites work (P2860)
Q47422276" The role of CXCR3 in neurological diseases".
Q40530656Activated GL7+ B cells are maintained within the inflamed CNS in the absence of follicle formation during viral encephalomyelitis.
Q36905550Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury
Q52680802Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent Responses.
Q99709718An immunotherapy effect analysis in Rasmussen encephalitis
Q36646146Anti-N-methyl-D-aspartate receptor encephalitis: the clinical course in light of the chemokine and cytokine levels in cerebrospinal fluid.
Q38458768Astrocyte pathology in Alexander disease causes a marked inflammatory environment
Q38964762C-X-C motif chemokine 10 in non-alcoholic steatohepatitis: role as a pro-inflammatory factor and clinical implication
Q36788638CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
Q92712543Central Nervous System Inflammatory Aggregates in the Theiler's Virus Model of Progressive Multiple Sclerosis
Q59354509Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease
Q28084132Control of autoimmune CNS inflammation by astrocytes
Q88712306Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV
Q26779177Hypersensitivity Responses in the Central Nervous System
Q38272285Immune responses to non-tumor antigens in the central nervous system.
Q90706107Innate Immune Responses and Viral-Induced Neurologic Disease
Q59352505Intercellular Communication Is Key for Protective IFNα/β Signaling During Viral Central Nervous System Infection
Q40527857Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis
Q38084075Intrathecal humoral immunity to encephalitic RNA viruses.
Q95660583Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system
Q33606456PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis
Q34059107Progression from IgD+ IgM+ to isotype-switched B cells is site specific during coronavirus-induced encephalomyelitis.
Q41933450Protective Humoral Immunity in the CNS Requires Peripheral CD19-Dependent Germinal Center Formation Following Coronavirus Encephalomyelitis.
Q39388323Protective and Pathological Immunity during Central Nervous System Infections
Q41981639Role of peripheral immune response in microglia activation and regulation of brain chemokine and proinflammatory cytokine responses induced during VSV encephalitis.
Q64071635The Maintenance of Memory Plasma Cells
Q36633166The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis
Q92251928Utility of chemokines CCL2, CXCL8, 10 and 13 and interleukin 6 in the pediatric cohort for the recognition of neuroinflammation and in the context of traditional cerebrospinal fluid neuroinflammatory biomarkers
Q57481153Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes

Search more.