Reducing the genotoxic potential of retroviral vectors

scientific article published on January 2008

Reducing the genotoxic potential of retroviral vectors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/978-1-60327-248-3_12
P8608Fatcat IDrelease_vlplpelum5dbje32yw36gtceim
P932PMC publication ID2394199
P698PubMed publication ID18470646
P5875ResearchGate publication ID5380248

P2093author name stringRobert G Hawley
Teresa S Hawley
Ali Ramezani
P2860cites workAnalysis of mutation in human cells by using an Epstein-Barr virus shuttle systemQ24628961
The protein CTCF is required for the enhancer blocking activity of vertebrate insulatorsQ28142800
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integrationQ28242708
The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors.Q53475878
Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.Q53869055
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.Q54662841
Small changes in expression affect predisposition to tumorigenesisQ59115695
The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteinsQ64379058
Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markersQ68809190
Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope proteinQ74171668
Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human bloodQ77684631
Murine leukemia induced by retroviral gene markingQ77975543
Hematopoietic stem cellsQ79399529
Species- and cell type-specific requirements for cellular transformationQ80482709
EVI1 and hematopoietic disorders: history and perspectivesQ28284034
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
A third-generation lentivirus vector with a conditional packaging systemQ29616120
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivoQ29616612
Transcription start regions in the human genome are favored targets for MLV integrationQ29618456
Multiparameter flow cytometry of fluorescent protein reportersQ31049416
Detection and enrichment of hematopoietic stem cells by side population phenotypeQ33198498
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemiaQ33330210
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.Q33643620
Development of a self-inactivating lentivirus vector.Q33784841
Self-inactivating lentivirus vector for safe and efficient in vivo gene deliveryQ33786060
Mobilization and mechanism of transcription of integrated self-inactivating lentiviral vectorsQ33843471
Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vectorQ33856071
Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv miceQ33862662
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activitiesQ34067751
RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacyQ34342598
A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in DrosophilaQ34352447
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.Q34508425
Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cellsQ34614346
Progress toward vector design for hematopoietic stem cell gene therapyQ34729423
RTCGD: retroviral tagged cancer gene databaseQ34923778
American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cellsQ35195407
A chromatin insulator protects retrovirus vectors from chromosomal position effectsQ35198059
Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cellsQ35604467
The role of signal transducer and activator of transcription factors in leukemogenesisQ35628327
Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cellsQ35847760
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cellsQ35848227
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesisQ35848246
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaqueQ35848273
Pseudotransduction of hepatocytes by using concentrated pseudotyped vesicular stomatitis virus G glycoprotein (VSV-G)-Moloney murine leukemia virus-derived retrovirus vectors: comparison of VSV-G and amphotropic vectors for hepatic gene transferQ35859108
Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable.Q35929299
Characterization of the chicken beta-globin insulatorQ35956059
Retrovirus silencer blocking by the cHS4 insulator is CTCF independentQ36079373
Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transferQ36231835
Chromatin boundaries and chromatin domains.Q36238580
Tumor suppressor geneticsQ36252762
Molecular genetics of acute lymphoblastic leukemiaQ36254588
Genome-wide analysis of retroviral DNA integrationQ36263002
Silencing and variegation of gammaretrovirus and lentivirus vectorsQ36301560
Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimerasQ36362432
Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors.Q36424249
Genotoxicity of retroviral integration in hematopoietic cells.Q36453658
Retrovirus vectors: toward the plentivirus?Q36457016
Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cellsQ36506251
Stable gammaretroviral vector expression during embryonic stem cell-derived in vitro hematopoietic developmentQ36665437
Integrated self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integrationQ36684330
Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumorsQ36780634
A safe packaging line for gene transfer: separating viral genes on two different plasmidsQ36865708
Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivoQ36873087
Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible systemQ37323864
Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.Q37335536
Tumorigenesis by slow-transforming retroviruses--an updateQ38012047
The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.Q39591112
Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vectorQ40171207
Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectorsQ40269711
Transient gene expression by nonintegrating lentiviral vectorsQ40300665
Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expressionQ40365103
Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cellsQ40492460
Sustained phenotypic correction of hemophilia a mice following oncoretroviral-mediated expression of a bioengineered human factor VIII gene in long-term hematopoietic repopulating cellsQ40499239
Self-inactivating retroviral vectors with improved RNA processing.Q40515056
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectorsQ40610397
Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulatorQ40670749
Kinetic analyses of stability of simple and complex retroviral vectorsQ40728863
Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34+ cellsQ40818099
Lentiviral vectors for enhanced gene expression in human hematopoietic cellsQ40841789
Insertional mutagenesis and the transformation of hematopoietic stem cells.Q40852921
Establishment of a novel factor-dependent myeloid cell line from primary cultures of mouse bone marrowQ41703550
Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytesQ42798184
Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cellsQ44022852
Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesisQ45855676
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical researchQ45857905
Versatile retroviral vectors for potential use in gene therapyQ45867146
Gene therapy insertional mutagenesis insightsQ45871758
Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemiaQ45873554
Double-copy bicistronic retroviral vector platform for gene therapy and tissue engineering: application to melanoma vaccine developmentQ45884879
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal miceQ45885733
Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligandQ45889081
Developmental potential and dynamic behavior of hematopoietic stem cells.Q52261166
P407language of work or nameEnglishQ1860
P921main subjectgenotoxicityQ1009245
P304page(s)183-203
P577publication date2008-01-01
P1433published inMethods in Molecular BiologyQ15752859
P1476titleReducing the genotoxic potential of retroviral vectors
P478volume434

Reverse relations

cites work (P2860)
Q37021156Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential
Q36956171Comparison of human coagulation factor VIII expression directed by cytomegalovirus and mammary gland-specific promoters in HC11 cells and transgenic mice
Q37268992Correction of murine hemophilia A following nonmyeloablative transplantation of hematopoietic stem cells engineered to encode an enhanced human factor VIII variant using a safety-augmented retroviral vector
Q55417064Factor VIII delivered by haematopoietic stem cell-derived B cells corrects the phenotype of haemophilia A mice.
Q34539879Immunization delivered by lentiviral vectors for cancer and infectious diseases
Q35755987Strategies to insulate lentiviral vector-expressed transgenes

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