Molecular alterations in pediatric sarcomas: potential targets for immunotherapy

scientific article published on January 1998

Molecular alterations in pediatric sarcomas: potential targets for immunotherapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/13577149878037
P932PMC publication ID2395387
P698PubMed publication ID18521238
P5875ResearchGate publication ID51397713

P2093author name stringJ A Berzofsky
C L Mackall
T J Goletz
L J Helman
P2860cites workChromosome translocation in peripheral neuroepitheliomaQ71438112
Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residuesQ71527769
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2Q72052802
Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumorQ72428441
Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological featuresQ73721197
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumoursQ24298221
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimersQ24302559
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcomaQ24304506
Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcomaQ24307456
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcomaQ24309359
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumorQ24312048
A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1Q24312796
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3Q24313754
A new member of the ETS family fused to EWS in Ewing tumorsQ24317176
EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft partsQ24317557
The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domainsQ24319886
SRE elements are binding sites for the fusion protein EWS-FLI-1Q24546126
Krüppel-associated boxes are potent transcriptional repression domainsQ24563259
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1Q24629399
The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in cultureQ24632107
EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocationsQ24634316
SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcomaQ27851510
Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomaQ28240093
Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemiasQ28240219
A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOPQ28240554
Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocationQ28242489
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERGQ28252253
Intra-abdominal desmoplastic small round-cell tumor. Report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individualsQ50803642
Chromosomal translocations in human cancer.Q52512616
The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric TranscriptsQ57756648
MIC2 is a specific marker for ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberratiQ57756690
Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpointsQ60035789
A Novel Reciprocal Chromosome Translocation t(11;22)(p13;q12) in an Intraabdominal Desmoplastic Small Round-Cell TumorQ67487724
Reciprocal translocation t(12;22)(q13;q13) in clear-cell sarcoma of tendons and aponeurosesQ67534089
Cytogenetic abnormalities in an intraabdominal desmoplastic small cell tumorQ67992109
Consistent chromosomal translocation in alveolar rhabdomyosarcomaQ69994392
Malignant melanoma of soft parts. A reassessment of clear cell sarcomaQ71020878
Promoters containing ATF-binding sites are de-regulated in cells that express the EWS/ATF1 oncogene.Q38295666
The oncogenic potential of Pax genesQ38318897
Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysisQ40016977
Malignant melanoma of soft parts involving the head and neck region: review of literature and case reportQ40372503
Dominance and crypticity of T cell antigenic determinantsQ40486347
The Ets family of transcription factorsQ40871575
Combinatorial generation of variable fusion proteins in the Ewing family of tumours.Q40874946
The biochemistry and cell biology of antigen processing and presentationQ40898211
In vitro predictors of therapeutic response in melanoma patients receiving tumor-infiltrating lymphocytes and interleukin-2.Q41027329
Fusion of the EWS1 and WT1 genes as a result of the t(11;22)(p13;q12) translocation in desmoplastic small round cell tumorsQ41127723
EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitroQ41207208
Pax genes and their roles in cell differentiation and developmentQ41239105
Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21ras peptide presented by HLA-A*0201.Q41347233
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridizationQ41367203
Chromosome translocation-mediated conversion of a tumor suppressor gene into a dominant oncogene: fusion of EWS1 to WT1 in desmoplastic small round cell tumors.Q41431767
The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities.Q41455523
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.Q41517584
In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53.Q41529681
Characterization of the ets oncogene family member, fli-1.Q41565730
Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reactionQ42027940
CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.Q42801637
A mutant p53 tumor suppressor protein is a target for peptide-induced CD8+ cytotoxic T-cellsQ42808144
Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion geneQ42830152
Cytogenetic findings in clear cell sarcoma of tendons and aponeuroses. Malignant melanoma of soft partsQ43466194
Genetic immunization is a simple method for eliciting an immune responseQ43857336
Induction of anti-self-immunity to cure cancerQ44641849
Isolation and characterization of the mouse homolog of SYT, a gene implicated in the development of human synovial sarcomas.Q48061783
Neuroscience at risk at NSF.Q48626355
Malignant melanoma of the soft parts (clear-cell sarcoma): confirmation of EWS and ATF-1 gene fusion caused by a t(12;22) translocationQ49094393
Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocationQ28259434
EWS/Fli-1 chimeric protein is a transcriptional activatorQ28285342
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcriptionQ28287446
Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12)Q28291773
Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUSQ28296815
Genomic organization of the human PAX3 gene: DNA sequence analysis of the region disrupted in alveolar rhabdomyosarcomaQ28303210
Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines.Q30463850
Targeting p53 as a general tumor antigenQ33638172
Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1.Q34114085
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcomaQ34334974
Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcomaQ34341396
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcomaQ34347334
Differential dependence on target site tissue for gene gun and intramuscular DNA immunizationsQ34425539
Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcomaQ34577679
Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumorQ34676847
Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma.Q35794887
Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2Q35830412
Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.Q36088999
Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytesQ36230021
Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcomaQ36300801
Immunotherapy of malignancy by in vivo gene transfer into tumorsQ36309790
A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytesQ36365851
Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccinesQ36366405
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.Q36374350
DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcomaQ36652613
Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins.Q36689270
Selective repression of transcriptional activators at a distance by the Drosophila Krüppel proteinQ36702540
A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomasQ36806784
EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cellsQ37362452
Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cellsQ37411183
Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcomaQ37588880
Antigen recognition by class I-restricted T lymphocytesQ38201551
The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activatorQ38292755
Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domainsQ38293532
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectimmunotherapyQ1427096
P304page(s)77-87
P577publication date1998-01-01
P1433published inSarcomaQ26841949
P1476titleMolecular alterations in pediatric sarcomas: potential targets for immunotherapy
P478volume2