Strychnine activates neuronal alpha7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains

scientific article published on November 1999

Strychnine activates neuronal alpha7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1999PNAS...9613421P
P356DOI10.1073/PNAS.96.23.13421
P932PMC publication ID23963
P698PubMed publication ID10557336
P5875ResearchGate publication ID12744280

P50authorEleonora PalmaQ42816618
P2093author name stringR Miledi
F Eusebi
B Barabino
S Fucile
P2860cites workHuman alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytesQ24310036
Effects of Zn2+ on wild and mutant neuronal alpha7 nicotinic receptorsQ36290537
Modulation of nicotinic acetylcholine receptors by strychnineQ36459451
Atomic force microscopy of cloned nicotinic acetylcholine receptor expressed in Xenopus oocytesQ36459824
Neuronal nicotinic threonine-for-leucine 247 alpha7 mutant receptors show different gating kinetics when activated by acetylcholine or by the noncompetitive agonist 5-hydroxytryptamine.Q36578906
Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domainQ36830063
Scanning tunneling microscopy imaging of Torpedo acetylcholine receptorQ37247102
Threonine-for-leucine mutation within domain M2 of the neuronal alpha(7) nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist.Q37317700
Structure of nicotinic acetylcholine receptorsQ40844926
Nicotinic receptors in the development and modulation of CNS synapses.Q41005061
Neuronal nicotinic acetylcholine receptorsQ41067261
Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.Q41142209
Mutations in the channel domain alter desensitization of a neuronal nicotinic receptorQ42617071
Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesisQ42618667
Activation of ion channels in the frog end-plate by high concentrations of acetylcholineQ42638916
Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutantsQ42670568
Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptorQ43582677
Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligand-gated ion channels.Q45946124
Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structureQ46399860
Effects of fluoxetine on wild and mutant neuronal alpha 7 nicotinic receptorsQ47692590
Homomeric and native alpha 7 acetylcholine receptors exhibit remarkably similar but non-identical pharmacological properties, suggesting that the native receptor is a heteromeric protein complexQ48246773
Strychnine: a potent competitive antagonist of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neuronsQ48515982
Nicotinic acetylcholine receptors assembled from the alpha7 and beta3 subunitsQ48915237
The alpha9 nicotinic acetylcholine receptor shares pharmacological properties with type A gamma-aminobutyric acid, glycine, and type 3 serotonin receptorsQ48924403
Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitineQ49019546
Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site propertiesQ49116776
Recording of single γ-aminobutyrate- and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytesQ72561011
Pharmacological characterization of alpha-bungarotoxin-sensitive acetylcholine receptors immunoisolated from chick retina: contrasting properties of alpha 7 and alpha 8 subunit-containing subtypesQ72623794
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)13421-13426
P577publication date1999-11-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleStrychnine activates neuronal alpha7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains
P478volume96

Reverse relations

cites work (P2860)
Q40673378Amyloid beta(1-42) peptide alters the gating of human and mouse alpha-bungarotoxin-sensitive nicotinic receptors.
Q42671582Evidence for a centrally located gate in the pore of a serotonin-gated ion channel.
Q45226996Glycine receptors regulate dopamine release in the rat nucleus accumbens
Q42926500Identification of Critical Elements Determining Toxins and Insecticide Affinity, Ligand Binding Domains and Channel Properties
Q43782822Inhibition of nicotinic acetylcholine receptors by bicuculline
Q34660492Nicotinic acetylcholine receptors in autonomic ganglia
Q37453095Pore structure of the Cys-loop ligand-gated ion channels
Q44394165Properties of neuronal alpha7 mutant nicotinic acetylcholine receptors gated by bicuculline
Q43908063Serotonin antagonizes the human neuronal alpha7 nicotinic acetylcholine receptor and becomes an agonist after L248T alpha7 mutation.
Q30513952Tightening of the ATP-binding sites induces the opening of P2X receptor channels