Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.

scientific article published on 5 October 2015

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/ANNRHEUMDIS-2015-207742
P932PMC publication ID4789686
P698PubMed publication ID26438374
P5875ResearchGate publication ID282645648

P50authorPhillip T NewtonQ63381259
Andrei S ChaginQ55002548
Thibault BouderliqueQ56998031
Björn BareniusQ57001657
P2093author name stringLei Li
Karuna K Vuppalapati
P2860cites workOsteoarthritisQ83296258
Guidelines for the use and interpretation of assays for monitoring autophagyQ21996341
Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental modelQ24296780
Molecules and their functions in autophagyQ24622004
mTOR signaling in growth control and diseaseQ24634174
Crosstalk between apoptosis, necrosis and autophagyQ26829723
Autophagy: from phenomenology to molecular understanding in less than a decadeQ29614174
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritisQ33729300
Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.Q34228180
Osteoarthritis severity is sex dependent in a surgical mouse modelQ34598788
Discovery of Atg5/Atg7-independent alternative macroautophagyQ34612369
Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.Q35803625
Autophagy in osteoblasts is involved in mineralization and bone homeostasisQ35852850
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagyQ36631143
Suppression of autophagy in osteocytes mimics skeletal agingQ36929011
Cartilage homeostasis in health and rheumatic diseasesQ37270714
The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.Q37791706
Estrogens, osteoarthritis and inflammationQ38076945
Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth RetardationQ38863777
The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis.Q45919828
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.Q53061352
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectosteoarthritisQ62736
P304page(s)627-631
P577publication date2015-10-05
P1433published inAnnals of the Rheumatic DiseasesQ4767876
P1476titleTargeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis
P478volume75

Reverse relations

cites work (P2860)
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Q55371500Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered.
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Q38873681Autophagy: controlling cell fate in rheumatic diseases
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Q88461809Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint
Q92778431Loss of autophagy in chondrocytes causes severe growth retardation
Q58751612MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12
Q47766972MicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis
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Q58719538Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300
Q58699693TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation
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Q64068731miR-21-5p protects IL-1β-induced human chondrocytes from degradation
Q89773780miRNA-411 Regulates Chondrocyte Autophagy in Osteoarthritis by Targeting Hypoxia-Inducible Factor 1 alpha (HIF-1α)

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