Aldosterone-induced fibrosis in the kidney: questions and controversies

scientific article published on 25 June 2011

Aldosterone-induced fibrosis in the kidney: questions and controversies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1053/J.AJKD.2011.03.029
P932PMC publication ID4792515
P698PubMed publication ID21705125

P2093author name stringRujun Gong
David J Morris
Andrew S Brem
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mTOR complex-2 activates ENaC by phosphorylating SGK1.Q33834293
The sgk, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channelQ33888851
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ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF RNA SYNTHESIS.Q34417317
Aldosterone in progressive renal diseaseQ34440218
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Dexamethasone induces connective tissue growth factor expression in renal tubular epithelial cells in a mouse strain-specific mannerQ35087985
Mechanisms of tubulointerstitial fibrosisQ35741776
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The effect of cortisone, hydrocortisone, and 9 alpha-fluoro-16 alpha-hydroxy-Delta 1-hydrocortisone on the action of desoxycorticosterone an aldosterone with respect to electrolyte excretionQ79293360
Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1Q80149639
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Aldosterone activates NF-kappaB in the collecting duct.Q37042182
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Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high saltQ37406166
Renal aldosterone receptors: studies with (3H)aldosterone and the anti-mineralocorticoid (3H)spirolactone (SC-26304).Q37440068
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Early aldosterone up-regulated genes: new pathways for renal disease?Q38350537
Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangiumQ38624678
Spironolactone antagonism of aldosterone action on Na+ transport and RNA metabolism in toad bladder epitheliumQ40067290
Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial originQ40114458
Aldosterone receptor occupancy and sodium transport in the urinary bladder of Bufo marinusQ40175507
Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studiesQ40557687
11 beta-Hydroxysteroid dehydrogenase in renal collecting duct cellsQ40756226
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The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2.Q40806489
Glucocorticoid metabolism in proximal tubules modulates angiotensin II-induced electrolyte transportQ40951322
Mineralocorticoids, salt, hypertension: effects on the heartQ41057086
Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activityQ43143831
Progressive hypertension associated with hypokalemic alkalosisQ44223650
Aldosterone/salt induces renal inflammation and fibrosis in hypertensive ratsQ44390510
Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosisQ44559284
11-Dehydrocorticosterone, a glucocorticoid metabolite, inhibits aldosterone action in toad bladderQ45036384
Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivationQ46064901
Absence of circulating aldosterone attenuates foreign body reaction around surgical suturesQ46092466
Spironolactone suppresses inflammation and prevents L-NAME-induced renal injury in ratsQ46314707
The aggravating mechanisms of aldosterone on kidney fibrosisQ46542770
Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertensionQ46564805
Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cellsQ46681426
Regression of existing glomerulosclerosis by inhibition of aldosteroneQ46726706
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.Q46956257
Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1.Q51089166
Developmental changes in rat renal 11 beta-hydroxysteroid dehydrogenase.Q52217765
Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2.Q53499338
SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment.Q54609647
Mineralocorticoid Receptor Blockade But Not Steroid Withdrawal Reverses Renal Fibrosis in Deoxycorticosterone/Salt RatsQ58433463
The physiological response to aldosterone in adrenalectomized and intact rats and its sex dependenceQ69478161
Nongenomic effects of aldosterone on intracellular pH in vascular smooth muscle cellsQ71138385
Glucocorticoid receptors in rat kidney cortical tubules enriched in proximal and distal segmentsQ71462354
Identification of four types of steroid by their interaction with mineralocorticoid receptors in the toad bladderQ71615298
Other physiological considerations of protective mechanisms of mineralocorticoid actionQ72444575
Aldosterone: a mediator of myocardial necrosis and renal arteriopathyQ73027730
Influence of dietary sodium on the renal isoforms of 11 beta-hydroxysteroid dehydrogenaseQ73249467
P433issue3
P304page(s)471-479
P577publication date2011-06-25
P1433published inAmerican Journal of Kidney DiseasesQ4744250
P1476titleAldosterone-induced fibrosis in the kidney: questions and controversies
P478volume58

Reverse relations

cites work (P2860)
Q3448397611β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
Q27333455Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats
Q38185015Aldosterone synthase inhibitors in cardiovascular and renal diseases
Q51659952CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats.
Q26795398Combination use of medicines from two classes of renin-angiotensin system blocking agents: risk of hyperkalemia, hypotension, and impaired renal function
Q38763624Epidermal growth factor receptor signaling mediates aldosterone-induced profibrotic responses in kidney
Q26799443Horizon 2020 in Diabetic Kidney Disease: The Clinical Trial Pipeline for Add-On Therapies on Top of Renin Angiotensin System Blockade
Q37997980Organ repair and regeneration: an overview.
Q38003564Perioperative considerations in patients with adrenal tumors.
Q38812335Spironolactone in Post-Transplant Proteinuria: A Safe Alternative Therapy.
Q38209811Therapeutic approaches to diabetic nephropathy--beyond the RAS.
Q33907249Treatment of diabetic kidney disease: current and future targets

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