Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity

scientific article published on 3 March 2010

Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPRENAL.00532.2009
P698PubMed publication ID20200098

P2093author name stringRujun Gong
David J Morris
Yan Ge
Andrew S Brem
Evelyn Tolbert
Lance Dworkin
P2860cites workInteractions of mineralocorticoids and glucocorticoids in epithelial target tissuesQ33888906
THE ACTION OF ALDOSTERONE AND RELATED CORTICOSTEROIDS ON SODIUM TRANSPORT ACROSS THE TOAD BLADDERQ33954319
Plasminogen activator inhibitor-1 and the kidneyQ33960082
Infusion of aldosterone, 9-alpha-fluorohydrocortisone and antidiuretic hormone into the renal artery of normal and adrenalectomized, unanesthetized dogs: effect on electrolyte and water excretion.Q34243823
Dexamethasone induces connective tissue growth factor expression in renal tubular epithelial cells in a mouse strain-specific mannerQ35087985
Forestalling fibrosisQ35600922
Renal injury due to renin-angiotensin-aldosterone system activation of the transforming growth factor-beta pathwayQ36598311
Aldosterone activates NF-kappaB in the collecting duct.Q37042182
Role of aldosterone in the remnant kidney model in the rat.Q37358980
Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangiumQ38624678
Co-localization of glucocorticoid metabolizing and prostaglandin synthesizing enzymes in rat kidney and liverQ39928055
Aldosterone receptor occupancy and sodium transport in the urinary bladder of Bufo marinusQ40175507
The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2.Q40806489
Effect of aldosterone on renal transforming growth factor-betaQ44886467
11-Dehydrocorticosterone, a glucocorticoid metabolite, inhibits aldosterone action in toad bladderQ45036384
Furosemide and the progression of left ventricular dysfunction in experimental heart failureQ45056655
Salt in the woundQ46178188
Spironolactone suppresses inflammation and prevents L-NAME-induced renal injury in ratsQ46314707
Glycogen synthase kinase 3beta: a novel marker and modulator of inflammatory injury in chronic renal allograft diseaseQ46373640
The aggravating mechanisms of aldosterone on kidney fibrosisQ46542770
Regression of existing glomerulosclerosis by inhibition of aldosteroneQ46726706
11beta-Hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese womenQ46929674
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.Q46956257
Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cellsQ47618682
The Roles of Plasma Binding and Receptor Specificity in the Mineralocorticoid Action of Aldosterone1Q48014590
Can renal fibrosis be reversed?Q52047488
Developmental changes in rat renal 11 beta-hydroxysteroid dehydrogenase.Q52217765
Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2.Q53499338
Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: targeting the inflamed vascular endothelium.Q53607563
P433issue5
P304page(s)F1178-87
P577publication date2010-03-03
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleDirect fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity
P478volume298

Reverse relations

cites work (P2860)
Q36175955A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice.
Q58778381Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling
Q34257435Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.
Q36210088Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.
Q36688855Aldosterone-induced fibrosis in the kidney: questions and controversies
Q64126983Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice
Q64260873Brain natriuretic peptide mitigates TIMP2 induction and reinstates extracellular matrix catabolic activity GSK3β inhibition in glomerular podocytes exposed to a profibrogenic milieu
Q44939785Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice.
Q47603517MiR-34c-5p and CaMKII are involved in aldosterone-induced fibrosis in kidney collecting duct cells
Q37342099Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription
Q101578601Role of mineralocorticoid receptor antagonists in kidney diseases
Q26996385Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease

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