Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling

scientific article published in Scientific Reports

Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-29483-7
P932PMC publication ID6093907
P698PubMed publication ID30111886

P2093author name stringPei Wang
Rujun Gong
Zhangsuo Liu
Yan Ge
Lance Dworkin
Minglei Lu
Andrew Brem
P2860cites workPractical uses for ecdysteroids in mammals including humans: an updateQ24806380
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Glomerular hypertension, abnormal glomerular growth, and progression of renal diseasesQ33928107
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Aldosterone as a mediator of progressive renal disease: pathogenetic and clinical implicationsQ34198408
Glycogen synthase kinase 3β dictates podocyte motility and focal adhesion turnover by modulating paxillin activity: implications for the protective effect of low-dose lithium in podocytopathyQ34302891
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Therapeutic targeting of GSK3β enhances the Nrf2 antioxidant response and confers hepatic cytoprotection in hepatitis C.Q34678974
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High sirolimus levels may induce focal segmental glomerulosclerosis de novoQ80797353
Effects of testosterone on glomerular growth after uninephrectomyQ95823204
Aldosterone--a hormone of cardiovascular adaptation and maladaptationQ36392694
The renin-angiotensin system in glomerular podocytes: mediator of glomerulosclerosis and link to hypertensive nephropathyQ36467553
The podocyte's response to injury: role in proteinuria and glomerulosclerosisQ36474870
Sex differences and the role of sex steroids in renal injuryQ36497243
Gender differences in the renin-angiotensin and nitric oxide systems: relevance in the normal and diseased kidney.Q36724537
The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathyQ36803722
Phytoecdysteroids and anabolic-androgenic steroids--structure and effects on humansQ37066139
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Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease.Q37853831
Ecdysone signaling in adult Drosophila melanogasterQ37981809
Aldosterone blockade and the mineralocorticoid receptor in the management of chronic kidney disease: current concepts and emerging treatment paradigmsQ37984206
Proteinuria should be used as a surrogate in CKD.Q37990717
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Focal Segmental GlomerulosclerosisQ38938623
Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysteroneQ38979970
Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase.Q39477655
Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cellsQ39719269
Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore populationQ40192525
Ecdysteroids: A novel class of anabolic agents?Q41282434
Nephron mass as a risk factor for progression of renal diseaseQ41667489
A new method for large scale isolation of kidney glomeruli from miceQ42047954
Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against PodocytopathyQ42141815
Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activityQ43143831
Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate.Q43617519
Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 geneQ44191986
Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum carthamoides (Willd.) IljinQ44973757
A spectrum of morphologic lesions of focal segmental glomerulosclerosis by Columbia criteria in human immunodeficiency virus infectionQ45359194
The aggravating mechanisms of aldosterone on kidney fibrosisQ46542770
Body mass index and risk for end-stage renal diseaseQ46876497
The progression of chronic kidney disease: a 10-year population-based study of the effects of gender and age.Q46891097
FSGS as an Adaptive Response to Growth-Induced Podocyte StressQ47760613
Glomerular hyperfiltration: definitions, mechanisms and clinical implicationsQ48257561
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectecdysteroidQ138983
P304page(s)12225
P577publication date2018-08-15
P1433published inScientific ReportsQ2261792
P1476titleActivation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling
P478volume8

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Q90347754Mineralocorticoid receptor: A hidden culprit for hemodialysis vascular access dysfunctioncites workP2860

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