Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

scientific article published on 11 February 2013

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20120662
P932PMC publication ID3600899
P698PubMed publication ID23401487
P5875ResearchGate publication ID235524166

P50authorHelen M. ArthurQ39407032
Jonas FuxeQ54250889
Oriol CasanovasQ57157744
Jill R JohnsonQ57325700
Ross CordinerQ59123253
Kristian PietrasQ66213999
P2093author name stringPeter ten Dijke
Marie-José Goumans
Bengt R Johansson
Eliane Cortez
Zhenhua Zhai
Evangelia Pardali
Sara I Cunha
Marcela Franco
Charlotte Anderberg
Marta Páez-Ribes
P2860cites workInteraction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complexQ24294521
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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisQ28131703
Defective angiogenesis in mice lacking endoglinQ28144833
Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamideQ28203483
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Vascular endothelial growth factor B controls endothelial fatty acid uptake.Q39727853
Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.Q39753483
Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transductionQ40251249
Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapiesQ40751413
Characteristics and possible function of endoglin, a TGF-beta binding proteinQ40785136
Endothelial cell membranes contain podocalyxin--the major sialoprotein of visceral glomerular epithelial cellsQ41498433
Pericytes limit tumor cell metastasisQ41916240
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition.Q42044394
Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in endoglin heterozygous miceQ42406987
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Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormalityQ44385668
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.Q45158856
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Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression.Q46541963
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour modelsQ46659724
Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcomeQ47808993
Tumor neoangiogenesis by CD31 and CD105 expression evaluation in breast carcinoma tissue microarrays.Q51618784
Endoglin expression in early development is associated with vasculogenesis and angiogenesis.Q52126579
Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin.Q52532578
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Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis.Q53327257
Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated FibroblastsQ58214816
A cancer therapy resistant to resistanceQ59070138
Pathogenesis of Arteriovenous Malformations in the Absence of EndoglinQ60205822
Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglinQ73738309
Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosisQ74462138
Sustained enhanced growth of carcinoma EO771 in C57 black miceQ75781930
Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cellsQ77392041
Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapyQ77555510
Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancerQ78035700
Reduced angiogenic responses in adult Endoglin heterozygous miceQ82233917
Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progenyQ82554716
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P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)563-579
P577publication date2013-02-11
P1433published inJournal of Experimental MedicineQ3186912
P1476titleDeficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
P478volume210

Reverse relations

cites work (P2860)
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