Epileptiform stimulus increases Homer 1a expression to modulate synapse number and activity in hippocampal cultures

scientific article published on 28 December 2012

Epileptiform stimulus increases Homer 1a expression to modulate synapse number and activity in hippocampal cultures is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/JN.00580.2012
P932PMC publication ID3602934
P698PubMed publication ID23274309
P5875ResearchGate publication ID234010967

P2093author name stringYan Li
Jonathan Popko
Stanley A Thayer
Kelly A Krogh
P2860cites workHomer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptorsQ22007971
Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteinsQ22008754
The postsynaptic density proteins Homer and Shank form a polymeric network structureQ24645689
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteinsQ28141190
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1aQ28187839
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein HomerQ28202988
Enlightening the postsynaptic densityQ28258781
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonistQ28374719
Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signalingQ28564865
The self-tuning neuron: synaptic scaling of excitatory synapsesQ29616059
PSD-95 involvement in maturation of excitatory synapsesQ29616167
Regulation of dendritic spine morphology and synaptic function by Shank and HomerQ30014842
Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.Q30697805
On the cellular and network bases of epileptic seizures.Q31963797
Hippocampal gene expression analysis using the ORESTES methodology shows that homer 1a mRNA is upregulated in the acute period of the pilocarpine epilepsy modelQ33265442
Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticityQ33744346
Spine loss and other dendritic abnormalities in epilepsyQ34081340
Kindling and status epilepticus models of epilepsy: rewiring the brainQ34326607
Homeostatic scaling requires group I mGluR activation mediated by Homer1aQ34455735
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectorsQ35749646
Epileptic stimulus increases Homer 1a expression to modulate endocannabinoid signaling in cultured hippocampal neuronsQ36460227
Regulation of mitogen-activated protein kinases by glutamate receptorsQ36612272
Disease-modifying pathways in neurodegeneration.Q36621175
Anatomical and physiological plasticity of dendritic spinesQ36728838
Homer proteins in Ca2+ signaling by excitable and non-excitable cellsQ36873568
Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell deathQ37183208
Developmental roles for Homer: more than just a pretty scaffold.Q37338392
Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated Ih channelsQ37416357
The closing and opening of TRPC channels by Homer1 and STIM1.Q37868765
Neurotoxicity mediated by aberrant patterns of synaptic activity between rat hippocampal neurons in cultureQ39479989
Suppression of the intrinsic apoptosis pathway by synaptic activity.Q39499029
Enhanced gene silencing by the application of multiple specific small interfering RNAsQ40628982
Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: proposed role of synaptic reorganizationQ41482274
Synchronized paroxysmal activity in the developing thalamocortical network mediated by corticothalamic projections and "silent" synapsesQ41643914
Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouseQ42512154
Lithium increases synapse formation between hippocampal neurons by depleting phosphoinositidesQ43141745
NMDA receptor stimulation and brain-derived neurotrophic factor upregulate homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells.Q43610848
Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slicesQ44168213
Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesisQ44243000
Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slicesQ44267443
Input-specific spine entry of soma-derived Vesl-1S protein conforms to synaptic tagging.Q46011293
Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neuronsQ46419863
Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock.Q46606141
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).Q46761730
Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.Q46840656
Excitotoxic loss of post-synaptic sites is distinct temporally and mechanistically from neuronal deathQ46943480
vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesisQ48047127
Epileptiform discharges induced by combined application of bicuculline and 4-aminopyridine are resistant to standard anticonvulsants in slices of ratsQ48163271
The cannabinoid agonist Win55,212-2 inhibits calcium channels by receptor-mediated and direct pathways in cultured rat hippocampal neuronsQ48482096
Mechanisms underlying the neuropathological consequences of epileptic activity in the rat hippocampus in vitroQ48921054
Glutamate efflux from rat brain slices and cultures: a comparison of the depolarizing agents potassium, 4-aminopyridine, and veratrineQ72319562
Differential inhibition of glial K(+) currents by 4-APQ73280370
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1494-1504
P577publication date2012-12-28
P1433published inJournal of NeurophysiologyQ1709863
P1476titleEpileptiform stimulus increases Homer 1a expression to modulate synapse number and activity in hippocampal cultures
P478volume109

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cites work (P2860)
Q44462403A Microfluidic Platform for the Characterisation of CNS Active Compounds
Q35007551HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism
Q30638542HIV-1 Tat-induced changes in synaptically-driven network activity adapt during prolonged exposure
Q42229248HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways
Q50740820Postnatal development of Homer1a in the rat hippocampus.
Q47406216Postsynaptic density protein transcripts are differentially modulated by minocycline alone or in add-on to haloperidol: Implications for treatment resistant schizophrenia.
Q34354092Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death
Q55163927Synapse development organized by neuronal activity-regulated immediate-early genes.
Q48413586The role of Homer1b/c in neuronal apoptosis following LPS-induced neuroinflammation

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