Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining

scientific article published on 26 February 2016

Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1501654
P932PMC publication ID4799769
P698PubMed publication ID26921311

P2093author name stringMasumi Abe
Yao Xu
Katheryn Meek
Eric Hendrickson
Jessica A Neal
P2860cites workA vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cellsQ24548417
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaksQ24596775
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A human XRCC4-XLF complex bridges DNAQ24630031
XRCC4's interaction with XLF is required for coding (but not signal) end joiningQ24630098
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Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactionsQ27674365
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repairQ27919641
DNA-PK autophosphorylation facilitates Artemis endonuclease activityQ27919702
The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cellsQ28115800
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocationsQ28247857
The response to and repair of RAG-mediated DNA double-strand breaksQ28256889
A severe combined immunodeficiency mutation in the mouseQ28274531
The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangementsQ36603553
53BP1 facilitates long-range DNA end-joining during V(D)J recombinationQ36682376
Complementary functions of ATM and H2AX in development and suppression of genomic instabilityQ36756926
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.Q37036037
RAG: a recombinase diversifiedQ37171099
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaksQ37234327
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.Q37347174
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.Q37416485
The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavageQ37519459
DNA double-strand break repair in a cellular contextQ38196085
Functional overlaps between XLF and the ATM-dependent DNA double strand break responseQ38199848
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PRKDC mutations in a SCID patient with profound neurological abnormalitiesQ38955848
DNA-PK is essential only for coding joint formation in V(D)J recombinationQ39724861
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.Q40449393
Unraveling the complexities of DNA-dependent protein kinase autophosphorylationQ40603571
DNA uptake and repair enzyme access to transfected DNA is under reported by gene expressionQ40640079
SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiencyQ40787847
Signal joint formation is also impaired in DNA-dependent protein kinase catalytic subunit knockout cellsQ40848620
Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: implications for the role of DNA-dependent protein kinase in V(D)J recombinationQ40905044
A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formationQ41116024
V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repairQ41549015
Impairment of V(D)J recombination in double-strand break repair mutantsQ41560292
Not All SCID Pigs Are Created Equally: Two Independent Mutations in the Artemis Gene Cause SCID in Pigs.Q41666062
DNA-PKcs and ATM co-regulate DNA double-strand break repairQ42007528
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signalsQ45246384
H2AX prevents DNA breaks from progressing to chromosome breaks and translocationsQ46904251
The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombinationQ48313594
DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasiaQ48316202
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Rag mutations reveal robust alternative end joiningQ59098597
V(D)J recombination: a functional definition of the joining signalsQ69721561
Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombinationQ71843533
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombinationQ77398644
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombinationQ28307236
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivityQ28506163
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin lociQ28508203
Crystal structure of the V(D)J recombinase RAG1-RAG2Q30622421
Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20Q32082716
ATM prevents the persistence and propagation of chromosome breaks in lymphocytesQ33289263
RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stabilityQ33558920
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationQ33591110
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formationQ33597709
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombinationQ33616301
Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.Q33702830
Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.Q33948953
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoiningQ33958394
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplificationQ33979941
The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusionQ34146558
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.Q34320792
XLF regulates filament architecture of the XRCC4·ligase IV complexQ34433470
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.Q34541828
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functionsQ34549990
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formationQ34550115
V(D)J recombination: RAG proteins, repair factors, and regulationQ34667417
XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formationQ34669732
Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.Q34805011
DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repairQ34868235
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesisQ34992049
Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylationQ35077127
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.Q35148396
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombinationQ35159001
PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.Q35806314
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.Q35888831
Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathwayQ36089263
Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytesQ36106641
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.Q36229444
Biochemistry of V(D)J recombination.Q36397181
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)3032-3042
P577publication date2016-02-26
P1433published inJournal of ImmunologyQ3521441
P1476titleRestoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining
P478volume196