Genetics of arterial hypertension and hypotension

scientific article published on 30 January 2007

Genetics of arterial hypertension and hypotension is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00210-007-0133-2
P698PubMed publication ID17262198
P5875ResearchGate publication ID6542497

P50authorMarkus SchürksQ78712697
P2093author name stringDieter Rosskopf
Christian Rimmbach
Rafael Schäfers
P2860cites workMutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type IIIQ24317311
Association of a human G-protein beta3 subunit variant with hypertensionQ24319177
A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertensionQ24538746
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4Q24541348
Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiencyQ24561534
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndromeQ24563016
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndromeQ24563029
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2Q24564081
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activityQ24564608
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rateQ24613583
RGS2/G0S8 is a selective inhibitor of Gqalpha functionQ24648296
A genetic defect resulting in mild low-renin hypertensionQ24669744
Familial aggregation of blood pressure in 558 adopted childrenQ24680323
Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancyQ28140188
G protein beta 3 gene: structure, promoter, and additional polymorphismsQ28141391
Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertensionQ28145697
Congenitally defective aldosterone biosynthesis in humans: the involvement of point mutations of the P-450C18 gene (CYP11B2) in CMO II deficient patientsQ28181588
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failureQ28203023
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthaseQ28208090
beta-Adducin polymorphisms, blood pressure, and sodium excretion in three European populationsQ28209012
Identification of RGS2 and type V adenylyl cyclase interaction sitesQ28211957
Human hypertension caused by mutations in WNK kinasesQ28212182
Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertensionQ28238039
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channelQ28240272
Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defectsQ28242801
WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephronQ28250388
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertensionQ28257529
No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36Q28260486
Activating mutation of the renal epithelial chloride channel ClC-Kb, predisposing to hypertensionQ28262218
A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channelQ28273651
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1Q28275138
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediatedQ28281477
Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis.Q35882777
Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasoneQ35918455
Functional genomics of the dopaminergic system in hypertensionQ35952875
Adducin polymorphism: detection and impact on hypertension and related disordersQ36033843
Pharmacogenomics of blood pressure response to antihypertensive treatmentQ36155230
Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of miceQ36157768
Meta-analysis of the ACE gene in ischaemic strokeQ36317849
ACE polymorphismsQ36475898
Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populationsQ37360005
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitroQ37365783
Angiotensinogen T235 expression is elevated in decidual spiral arteriesQ37372462
Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expressionQ37388093
The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspectsQ37924766
Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunitQ38290561
The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertensionQ38324554
Polymorphism of gamma-adducin gene in genetic hypertension and mapping of the gene to rat chromosome 1q55.Q38343325
RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signalingQ38344549
Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patientsQ38481357
Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertensionQ38489772
Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na+, K+-ATPase alpha subunit in response to dopamineQ38611404
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticityQ39116365
Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals.Q39517168
Neurogenic hypertension: etiology and surgical treatment. I. Observations in 53 patientsQ39549885
Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunitQ39635647
Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients. A cell culture model for human hypertensionQ40305844
Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loopQ40417203
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptorsQ40442171
Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprololQ40576862
Interaction of Gbeta3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteinsQ40663703
Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patientsQ40682400
Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosisQ40749040
Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted traffickingQ40757155
Angiotensin I-converting enzyme and angiotensinogen gene interaction and prediction of essential hypertensionQ40857373
Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in essential hypertensionQ40879855
Dopamine-induced endocytosis of Na+,K+-ATPase is initiated by phosphorylation of Ser-18 in the rat alpha subunit and Is responsible for the decreased activity in epithelial cellsQ40980335
Renal mechanisms of genetic hypertension: from the molecular level to the intact organismQ41066735
Environmental and genetic sources of familial aggregation of blood pressure in Tecumseh, MichiganQ41597193
Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal.Q41665134
Liddle's syndromeQ41743739
Evidence for involvement of 3'-untranslated region in determining angiotensin II receptor coupling specificity to G-protein.Q42102644
Role of C/A polymorphism at -20 on the expression of human angiotensinogen geneQ42467428
A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptorQ42490743
Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contactQ42496275
Deletion at 12p in a Japanese child with brachydactyly overlaps the assigned locus of brachydactyly with hypertension in a Turkish familyQ43108960
Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetesQ43612366
Post-transcriptional regulation of the AT1 receptor mRNA. Identification of the mRNA binding motif and functional characterizationQ43626616
The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosisQ48951069
Association between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels.Q50866265
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study.Q50885930
Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition.Q50994672
Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men.Q51553957
Haplotype association analysis of AGT variants with hypertension-related traits: the HyperGEN study.Q51958230
An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gbeta3 C825T polymorphism.Q52019856
Linkage analysis of candidate genes and gene-gene interactions in chinese hypertensive sib pairs.Q52211595
Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy.Q52375631
Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system.Q52413462
M235T angiotensinogen gene polymorphism and cardiovascular renal risk.Q52910086
Autosomal dominant hypertension and brachydactyly in a Turkish kindred resembles essential hypertension.Q53003916
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.Q54197421
Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study.Q54350600
beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension.Q54594315
Alpha-adducin gene polymorphism is associated with essential hypertension in Chinese: a case-control and family-based study.Q54752863
Intracranial aneurysm and hemorrhagic stroke in glucocorticoid-remediable aldosteronism.Q55067356
A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertensionQ55671192
Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregation-linkage analysisQ56893651
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension studyQ56970838
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12pQ56982381
A cross-over medication trial for patients with autosomal-dominant hypertension with brachydactylyQ56982819
Posterior fossa neurovascular anomalies in essential hypertensionQ56983100
The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal riskQ57085852
Linkage of the Angiotensinogen Gene to Essential HypertensionQ57282024
Cardiovascular risk factors in a french canadian population: Resolution of genetic and familial environmental effects on blood pressure using twins, adoptees, and extensive information on environmental correlatesQ57316028
Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genesQ57378094
ACE and α-Adducin Polymorphism as Markers of Individual Response to Diuretic TherapyQ57397144
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarctionQ57606113
Apparent mineralocorticoid excess in a Brazilian kindredQ57632859
Angiotensin II type 1 receptor−153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjectsQ59275530
Real-time PCR for rapid genotyping of angiotensin-converting enzyme insertion/deletion polymorphismQ59311911
Polymorphism in oestrogen response element associated with variation in plasma angiotensinogen concentrations in healthy pregnant womenQ59367291
G-Protein β3 Subunit Gene ( GNB3 ) Variant in Causation of Essential HypertensionQ59590798
α-Adducin 460Trp Allele Is Associated With Erythrocyte Na Transport Rate in North Sardinian Primary HypertensivesQ61466149
Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjectsQ61771206
Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21Q64050276
Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndromesQ67729249
Racial difference in the relationship of an angiotensin I-converting enzyme gene polymorphism to serum angiotensin I-converting enzyme activityQ70978480
Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12Q71167669
Angiotensin-converting enzyme gene polymorphism in hypertensive individuals with parental history of strokeQ71477302
Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMKQ71614570
Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studiesQ71953141
The deletion polymorphism of the angiotensin I-converting enzyme gene is associated with target organ damage in essential hypertensionQ71959530
Angiotensin II type 1 receptor gene polymorphisms in human essential hypertensionQ72036783
Brief report: Liddle's syndrome revisited--a disorder of sodium reabsorption in the distal tubuleQ72666321
Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the JapaneseQ72791685
DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophyQ72893483
Angiotensinogen and angiotensin-converting enzyme genotypes, and day and night blood pressures in elderly Japanese hypertensivesQ72992037
A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptorQ22009445
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptorQ22254872
A comprehensive review of genetic association studiesQ22337119
Adducin: structure, function and regulationQ24290117
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressureQ24299443
A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan originQ24302509
Rocks: multifunctional kinases in cell behaviourQ24303641
A molecular variant of angiotensinogen associated with preeclampsiaQ24309422
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channelQ24310075
Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporterQ24311551
Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2Q24313292
A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 familiesQ24313454
Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type IQ24315663
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of ageQ28283140
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndromeQ28288744
Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodiumQ28291873
Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenaseQ28297160
Genetic diseases associated with heterotrimeric G proteinsQ28306180
Glucocorticoid-remediable aldosteronism in a large kindred: clinical spectrum and diagnosis using a characteristic biochemical phenotypeQ28319529
A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channelQ28512481
Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transportQ28575497
WNK kinases regulate thiazide-sensitive Na-Cl cotransportQ28584824
Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its traffickingQ30169021
G protein-coupled receptor kinase 4 gene variants in human essential hypertensionQ30309044
Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers.Q30310235
In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humansQ30320973
Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculationQ30842107
SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models.Q30983108
C825T polymorphism of the G protein beta(3)-subunit and antihypertensive response to a thiazide diureticQ32072905
RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.Q32102010
G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertensionQ32184390
Mutation in the CYP21B gene (Ile-172----Asn) causes steroid 21-hydroxylase deficiencyQ33557866
Hereditary Brachydactyly Associated with HypertensionQ33585733
Gene targeting approaches to analyzing hypertension.Q33686736
Glucocorticoid-remediable aldosteronism and pregnancyQ33840800
QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order AmishQ33906173
Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart studyQ33922221
Three ways to make a vesicleQ33938411
Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolismQ33938773
Angiotensinogen as a risk factor for essential hypertension in JapanQ34133604
Localization of a small genomic region associated with elevated ACEQ34146741
Antihypertensive pharmacogenetics: getting the right drug into the right patientQ34154660
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient miceQ34177503
Genetic variants of WNK4 in whites and African Americans with hypertensionQ34193390
Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysisQ34205648
Genome-wide mapping of human loci for essential hypertensionQ34208939
The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of resultsQ34236470
A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channelsQ73023589
1166 A/C polymorphism of the angiotensin II type 1 receptor gene and the response to short-term infusion of angiotensin IIQ73026265
The role of alpha-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association studyQ73087451
Lack of association between angiotensin II type 1 receptor gene polymorphism and hypertension in JapaneseQ73103576
Association of angiotensin II type 1 receptor gene polymorphism with essential hypertensionQ73186366
Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacksQ73279512
G-Protein beta(3) subunit gene variant and left ventricular hypertrophy in essential hypertensionQ73371623
Renin-angiotensin system genetic polymorphisms and salt sensitivity in essential hypertensionQ73371731
ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whitesQ73435170
Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cellsQ73487478
Angiotensin II type 1 receptor gene A1166C polymorphism is associated with the increased risk of pregnancy-induced hypertensionQ73512417
Association analysis of beta(2)-adrenergic receptor polymorphisms with hypertension in JapaneseQ73567299
Evaluation of three polymorphisms in the promoter region of the angiotensin II type I receptor geneQ73569431
Association of a polymorphism at the 5'-region of the angiotensin II type 1 receptor with hypertensionQ73607029
Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotypeQ73623120
Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) CollaboratorsQ73858290
Positional genomic analysis identifies the beta(2)-adrenergic receptor gene as a susceptibility locus for human hypertensionQ73929740
Mutations in the Na-Cl cotransporter reduce blood pressure in humansQ74026246
A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertensionQ74052384
Polymorphism in the beta(1)-adrenergic receptor gene and hypertensionQ74180003
Association of sodium channel gamma-subunit promoter variant with blood pressureQ74236463
Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium dietQ74316955
Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphismQ74351904
Determination of human beta(2)-adrenoceptor haplotypes by denaturation selective amplification and subtractive genotypingQ74361626
Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertensionQ74385774
Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PEGASE study. Projet d'Etude des Gènes de l'Hypertension Artérielle Sévère à modérée EssentielleQ74418601
Angiotensin converting enzyme gene I/D polymorphism in essential hypertension and nephroangiosclerosisQ74601044
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertensionQ74615293
Association of GNAS1 gene variant with hypertension depending on smoking statusQ74742298
Families with autosomal dominant brachydactyly type E, short stature, and severe hypertensionQ77060899
Association of a sodium channel alpha subunit promoter variant with blood pressureQ77374106
Destabilization of AT(1) receptor mRNA by calreticulinQ77475998
The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjectsQ77478556
ACE (I/D) genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug (enalaprilat) in humansQ77554983
Polymorphisms of the beta2 -adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studiesQ77579720
Freely associatingQ77729306
Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of strokeQ77905014
Association of the G(s)alpha gene with essential hypertension and response to beta-blockadeQ78002981
Quantitative trait loci for blood pressure exist near the IGF-1, the Liddle syndrome, the angiotensin II-receptor gene and the renin loci in manQ78124937
Linkage analysis of twelve candidate gene loci regulating water and sodium metabolism and membrane ion transport in essential hypertensionQ78309515
Angiotensinogen gene haplotype and hypertension: interaction with ACE gene I alleleQ78744681
Absence of linkage between the angiotensin converting enzyme locus and human essential hypertensionQ43642189
Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population.Q43717170
Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemiaQ43796188
Angiotensinogen gene core promoter variants and non-modulating hypertensionQ43829648
Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressureQ43922014
Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazideQ44173366
Effects of ACE I/D and AT1R-A1166C polymorphisms on blood pressure in a healthy normotensive primary care population: first results of the Hippocates studyQ44289108
A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockadeQ44413115
Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjectsQ44502142
Association of the GNAS1 gene variant with hypertension is dependent on alcohol consumptionQ44513761
The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibitionQ44553741
Angiotensin II-mediated cellular responses: a role for the 3'-untranslated region of the angiotensin AT1 receptorQ44582030
Gly389Arg polymorphism of β1-adrenergic receptor is associated with the cardiovascular response to metoprololQ44611160
Venous response to nitroglycerin is enhanced in young, healthy carriers of the 825T allele of the G protein β3 subunit gene (GNB3)Q44637341
Angiotensinogen gene polymorphisms: relationship to blood pressure response to antihypertensive treatment. Results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trialQ44710151
Autosomal-dominant hypertension with type E brachydactyly is caused by rearrangement on the short arm of chromosome 12.Q44715090
Angiotensinogen gene and essential hypertension in the Japanese: extensive association study and meta-analysis on six reported studiesQ44745690
WNK4 intron 10 polymorphism is not associated with hypertensionQ44766964
Beta1-adrenergic receptor gene polymorphisms and response to beta1-adrenergic receptor blockade in patients with essential hypertensionQ44966749
Molecular basis of human hypertension: role of angiotensinogenQ45118696
Effects of systemic endothelin A receptor antagonism in various vascular beds in men: in vivo interactions of the major blood pressure-regulating systems and associations with the GNB3 C825T polymorphismQ45145996
Hypertension and Severe Hyperkalaemia Associated with Suppression of Renin and Aldosterone and Completely Reversed by Dietary Sodium RestrictionQ45163111
Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita StudyQ45238928
Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20 lyase deficiencyQ45345344
Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.Q45984379
Associations between hypertension and genes in the renin-angiotensin system.Q46167954
Polymorphisms of the gamma subunit of the epithelial Na+ channel in essential hypertensionQ46171808
beta-2 Adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult CaucasiansQ46243319
Genetic contribution to the acute effects of angiotensin II type 1 receptor blockadeQ46388237
Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p.Q46389857
Genetics of human hypertensionQ46420746
Association of a GNAS1 gene variant with hypertension and diabetes mellitusQ46491364
G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical strokeQ46539080
Insulin-mediated venodilation is impaired in young, healthy carriers of the 825T allele of the G-protein beta3 subunit gene (GNB3).Q46551894
T594M variant of the epithelial sodium channel beta-subunit gene and hypertension in individuals of African ancestry in South Africa.Q46581101
Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in LondonQ46590647
Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signalingQ46652728
Epithelial sodium channel allele T594M is not associated with blood pressure or blood pressure response to amilorideQ46667408
Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical studyQ46731232
Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension.Q46748212
Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general populationQ46814882
Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white AmericansQ46887790
Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredityQ46933292
Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor.Q46946284
beta-2 adrenergic receptor gene variations, blood pressure, and heart size in normal twinsQ47246737
Two quantitative trait loci affect ACE activities in Mexican-AmericansQ47282894
Blood pressure in relation to three candidate genes in a Chinese population.Q47733615
Genetic polymorphisms of the beta-adrenergic system: association with essential hypertension and response to beta-blockadeQ47803207
A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen geneQ47888290
The T-allele of the C825T polymorphism is associated with higher arterial stiffness in young healthy malesQ47901790
Beta-2 adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: The Bergen Blood Pressure StudyQ48026232
Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white malesQ48035561
Neurovascular compression at the ventrolateral medulla in autosomal dominant hypertension and brachydactylyQ48626109
Renin-angiotensin system genetic polymorphisms and cerebral white matter lesions in essential hypertensionQ48667673
A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African AmericansQ78861726
Linkage analysis of five candidate genes and essential hypertension in 106 Chinese nuclear familiesQ78906952
Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER ProjectQ79080495
Effects of endothelial nitric oxide synthase, α-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazideQ79156049
A molecular switch controlling renal sodium and potassium excretionQ79333308
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubuleQ80238253
Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan ratsQ80841917
The beta2-adrenoceptor gene and hypertension: is it the promoter or the coding region or neither?Q83311011
Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubuleQ83948564
The adrenogenital syndromeQ34253530
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levelsQ34262228
Hypertension treatment and control in five European countries, Canada, and the United StatesQ34279075
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypesQ34316687
Linkage disequilibrium and haplotype diversity in the genes of the renin-angiotensin system: findings from the family blood pressure programQ34373337
Evidence for an unidentified steroid in a child with apparent mineralocorticoid hypertensionQ34388923
A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.Q34448395
Mammalian G proteins and their cell type specific functionsQ34453802
Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertensionQ35015795
Genetics of blood pressure, hypertensive complications, and antihypertensive drug responsesQ35040887
Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system.Q35057155
G protein-coupled receptors regulate Na+,K+-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrinQ35107902
Two point mutations within the adducin genes are involved in blood pressure variationQ35210045
Haplotypes of angiotensinogen in essential hypertensionQ35250479
Pharmacogenetics of hypertension treatment: a structured reviewQ35596839
Beta-adrenoceptor polymorphismsQ35597242
Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertensionQ35751337
Linkage of the angiotensinogen gene locus to human essential hypertension in African CaribbeansQ35751908
P433issue5-6
P921main subjectarterial hypertensionQ41861
P304page(s)429-469
P577publication date2007-01-30
P1433published inNaunyn-Schmiedeberg's Archives of PharmacologyQ1468251
P1476titleGenetics of arterial hypertension and hypotension
P478volume374

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