Inecalcitol, an analog of 1,25D3, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system

scientific article published on 6 February 2013

Inecalcitol, an analog of 1,25D3, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CC.23846
P932PMC publication ID3610722
P698PubMed publication ID23388458

P2093author name stringWei Luo
Candace S Johnson
Donald L Trump
Wei-Dong Yu
Yingyu Ma
Alejandro A Hidalgo
Remi Delansorne
P2860cites workProspective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in MenQ22242854
The role of vitamin D in cancer preventionQ24545572
CYP24A1 inhibition enhances the antitumor activity of calcitriolQ34132307
The activation of Akt/PKB signaling pathway and cell survival.Q34405519
Dexamethasone enhances 1alpha,25-dihydroxyvitamin D3 effects by increasing vitamin D receptor transcriptionQ35378668
Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cellsQ35782892
The emerging role of the PI3-K-Akt pathway in prostate cancer progressionQ36050987
Vitamin D signalling pathways in cancer: potential for anticancer therapeuticsQ36919979
1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma modelQ36982956
Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancerQ39687107
Glucocorticoid regulation of the vitamin D receptorQ39882237
Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-mediated apoptosis in squamous cell carQ40243286
Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomeraseQ40504176
Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapyQ40883301
Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivoQ43503491
Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cellsQ43508934
Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis.Q43579777
Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elementsQ43584307
Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1.Q43594118
Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cellsQ44033494
The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitroQ44225920
Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer.Q44246934
Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression.Q44255811
Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor dosesQ44805762
Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interactionQ45280602
Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model systemQ73677763
Enhancement of 1,25-dihydroxyvitamin D3-mediated antitumor activity with dexamethasoneQ74121283
1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivoQ77861542
Vitamin DQ78117743
P433issue5
P921main subjectsquamous cell carcinomaQ681817
P1104number of pages10
P304page(s)743-752
P577publication date2013-02-06
P1433published inCell CycleQ1254166
P1476titleInecalcitol, an analog of 1,25D3, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system
P478volume12

Reverse relations

cites work (P2860)
Q371335231,25-Dihydroxyvitamin D3 modulates calcium transport in goat mammary epithelial cells in a dose- and energy-dependent manner
Q390271401α,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells
Q91938922Association among plasma 1,25(OH)2 D, ratio of 1,25(OH)2 D to 25(OH)D, and prostate cancer aggressiveness
Q61023219Calcitriol and cancer therapy: A missed opportunity
Q92107832Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement
Q57279890Chapter 20: Update on Pharmacologically-Relevant Vitamin D Analogs
Q47647199DHPLC Elution Patterns of VDR PCR Products Can Predict Prostate Cancer Susceptibility in African American Men.
Q37060783Effects of 1,25(OH)2D3 on proliferation and apoptosis of human glomerular mesangial cells
Q93015032Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment
Q88924562Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies
Q37695300The future of vitamin D analogs
Q85696571The role of vitamin D in cancer prevention
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Q55024961Vitamin D in prostate cancer.
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Q99405236Vitamin D inhibits the proliferation of Oral Squamous Cell Carcinoma by suppressing lncRNA LUCAT1 through the MAPK pathway

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