UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.

scientific article published on 23 December 2015

UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma. is …
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scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2015-07-656678
P932PMC publication ID4807423
P698PubMed publication ID26702068

P50authorAndrew L FeldmanQ42397592
P2093author name stringSajjad Hussain
Tibor Bedekovics
Paul J Galardy
P2860cites workTranscriptional analysis of the B cell germinal center reactionQ24554209
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphomaQ24613755
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signalingQ24629152
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingQ27860529
Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'AdulteQ28248195
The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolaseQ28941761
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
Reverse engineering of regulatory networks in human B cellsQ30004211
Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells.Q33634465
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centersQ34044132
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphomaQ34714068
Prognosis of patients with diffuse large B cell lymphoma not reaching complete response or relapsing after frontline chemotherapy or immunochemotherapyQ35218039
Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescentsQ35750976
Magnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysisQ35888947
Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profilingQ35909668
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesisQ36204234
Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomasQ36249443
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cellsQ36601348
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomicsQ36721503
Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP ConQ36799606
PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphomaQ37049376
Pediatric diffuse large B-cell lymphoma demonstrates a high proliferation index, frequent c-Myc protein expression, and a high incidence of germinal center subtype: Report of the French-American-British (FAB) international study groupQ37265785
A study of rituximab and ifosfamide, carboplatin, and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20+) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia: a report from the Children's Oncology GroupQ37310514
Double-hit B-cell lymphomasQ37813897
Relapsed/refractory diffuse large B-cell lymphomaQ37967335
Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignanciesQ38894421
Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptorQ39214595
PU.1-dependent regulation of UCH L1 expression in B-lymphoma cellsQ39556264
Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.Q39636568
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted miceQ39720046
Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survivalQ40237290
BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cellsQ40377462
PI3 kinase signals BCR-dependent mature B cell survivalQ41886641
AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.Q43059808
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentryQ43091743
High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapyQ43143099
Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Munster) Multicenter TrialQ45158002
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.Q51940347
Polycomb protein EZH2 expression in diffuse large B-cell lymphoma is associated with better prognosis in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone.Q53080173
Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in miceQ81747975
Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphomaQ83215929
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1564-1574
P577publication date2015-12-23
P1433published inBloodQ885070
P1476titleUCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma
P478volume127