The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

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The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase is …
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scholarly articleQ13442814

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P819ADS bibcode1989Sci...246..670W
P356DOI10.1126/SCIENCE.2530630
P3181OpenCitations bibliographic resource ID1915078
P698PubMed publication ID2530630
P5875ResearchGate publication ID20624781

P2093author name stringJ. Pohl
K. D. Wilkinson
K. M. Lee
J. M. Boss
P. Duerksen-Hughes
S. Deshpande
P433issue4930
P407language of work or nameEnglishQ1860
P921main subjectthiol-dependent deubiquitinaseQ21097542
Ubiquitin C-terminal hydrolase L3Q21126400
P304page(s)670–673
P577publication date1989-11-03
P1433published inScienceQ192864
P1476titleThe neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase
P478volume246

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cites work (P2860)
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Q71650075The innervation of the mystacial pad in the adult rat studied by anterograde transport of HRP conjugates
Q72711581The innervation of the mystacial pad of the rat as revealed by PGP 9.5 immunofluorescence
Q41958129The innervation of the splenic capsule in the guinea pig: an immunohistochemical and ultrastructural study.
Q39977138The role of PGP9.5 as a tumor suppressor gene in human cancer
Q37781736The role of deubiquitinating enzymes in apoptosis
Q38583099The role of deubiquitinating enzymes in spermatogenesis.
Q26828378The role of deubiquitinating enzymes in synaptic function and nervous system diseases
Q28205399The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
Q37866988The role of ubiquitylation in nerve cell development
Q31014920The spatiotemporal relationship among Schwann cells, axons and postsynaptic acetylcholine receptor regions during muscle reinnervation in aged rats
Q24527361The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase
Q45935293The three-dimensional distribution of nerves along the entire intrapulmonary airway tree of the adult rat and the anatomical relationship between nerves and neuroepithelial bodies.
Q34774553The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons
Q29618638The ubiquitin-proteasome proteolytic pathway
Q38075859The ubiquitin-proteasome system in retinal health and disease.
Q47807766The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine
Q37201976The value of immunohistochemistry on paraffin wax embedded tissue sections in the differentiation of small lymphocytic and mantle cell lymphomas
Q38290759Therapeutic strategies in Parkinson's disease: what we have learned from animal models
Q38062499Transcriptional and post-transcriptional regulation of β-secretase.
Q39052627Transcriptional regulation of human USP24 gene expression by NF-kappa B.
Q36861432Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration
Q46974852Traumatic brain injuries.
Q37519476Trophic factor and hormonal regulation of neurite outgrowth in sensory neuron-like 50B11 cells
Q27931184UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme
Q27933109UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation.
Q38829786UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein
Q50982636UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment.
Q43980721UCH-L1 inhibition involved in CREB dephosphorylation in hippocampal slices
Q36375134UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer
Q36727872UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Q48369163UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer.
Q37249509UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance
Q31077544UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan
Q28118734UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy
Q36562144UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression
Q34444406UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM.
Q50296505UCHL1, UCHL3 cleave ubiquitin adducts
Q64883693UCHL1/PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch.
Q38985872USP40 gene knockdown disrupts glomerular permeability in zebrafish
Q47321547Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB.
Q36812366Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity
Q92686693Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks
Q26741828Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Q39024141Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells
Q34228778Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions
Q48892814Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
Q48051302Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia
Q47169349Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.
Q36091119Ubiquitin C-terminal hydrolase l1 in tumorigenesis
Q34163790Ubiquitin C-terminal hydrolase l1 is expressed in mouse pituitary gonadotropes in vivo and gonadotrope cell lines in vitro
Q40794803Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress
Q39257016Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries
Q92035644Ubiquitin C-terminal hydrolase-L1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers
Q33799710Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation
Q34838590Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy
Q35147643Ubiquitin carboxyl terminal hydrolyase L1-suppressed autophagic degradation of p21WAF1/Cip1 as a novel feedback mechanism in the control of cardiac fibroblast proliferation
Q35050009Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts
Q33667738Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
Q47592158Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications
Q24318689Ubiquitin dimers control the hydrolase activity of UCH-L3
Q40794812Ubiquitin in neurodegenerative diseases
Q27661287Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation
Q48451497Ubiquitin, PGP 9.5 and dense body formation in trimethyltin intoxication: differential neuronal responses to chemically induced cell damage
Q37897536Ubiquitin, cell stress and diseases of the nervous system
Q39271369Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes
Q34019149Ubiquitin-mediated proteolysis in learning and memory
Q48812205Ubiquitin-mediated stress response in a rat model of brain transient ischemia/hypoxia
Q35186220Ubiquitination in postsynaptic function and plasticity
Q43902847Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form
Q42478519Ultrastructural localization of PGP 9.5 and ubiquitin immunoreactivities in rat ductus epididymidis epithelium
Q47986554Unique localization of protein gene product 9.5 in type B synoviocytes in the joints of the horse
Q36878887Unique spindle cells in the involved ileal segment of rats with congenital aganglionosis
Q42512400Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study
Q35723883Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line.
Q46802821cDNA cloning, sequence identification and tissue expression distribution of three novel porcine genes: UCHL3, RIT1 and CCND3.
Q47130601cPKCγ-mediated down-regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway.
Q36910190β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.
Q34448671β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency

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