Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease

scientific article published on May 2016

Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1159/000447239
P932PMC publication ID4965532
P698PubMed publication ID27504117

P50authorHenrik ZetterbergQ6252048
Kaj BlennowQ28321550
Per JohanssonQ52148201
Ulf AndreassonQ97016159
P2093author name stringJohan Svensson
Anders Wallin
Annika Öhrfelt
P2860cites workDJ-1 has a role in antioxidative stress to prevent cell deathQ24306633
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
Recognition of the polyubiquitin proteolytic signalQ24530006
“Mini-mental state”Q25938989
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's DiseaseQ27860795
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuronQ28589324
The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolaseQ28941761
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ29547554
Alzheimer's diseaseQ29616743
Mild cognitive impairment as a diagnostic entityQ29619568
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradationQ29622825
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteriaQ30458193
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's diseaseQ30493811
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's diseaseQ33764254
Research criteria for subcortical vascular dementia in clinical trialsQ34015506
Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhageQ34093020
Cerebrospinal fluid and plasma biomarkers in Alzheimer diseaseQ34098866
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibilityQ34157005
Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresisQ34256444
Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid studyQ34287865
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brainsQ34620363
Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer's diseaseQ35060833
Alzheimer's disease meets the ubiquitin-proteasome systemQ35935356
The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies.Q36051175
Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's diseaseQ36412536
Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer diseaseQ36545671
Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tanglesQ37426445
Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic proteinQ37430560
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau ProteinQ38829786
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up studyQ40349700
Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231.Q44091581
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseasesQ44727052
UCHL1 is a Parkinson's disease susceptibility geneQ47866612
The ubiquitin pathway in Parkinson's diseaseQ48015939
Cerebrospinal fluid profile of amyloid β42 (Aβ42), hTau and ubiquitin in North Indian Alzheimer's disease patients.Q48143268
Proteomics analysis of the Alzheimer's disease hippocampal proteomeQ48157842
Ubiquitin in cerebrospinal fluid in Alzheimer's disease and vascular dementia.Q48213108
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's diseaseQ48292097
Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's diseaseQ48310556
Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International WorkshopQ48342894
Cerebrospinal fluid neuron-specific enolase is reduced in Alzheimer's diseaseQ48379690
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's diseaseQ48408159
Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in ColombiaQ48541163
Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han populationQ48576454
Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brainQ48710955
Neuron-specific enolase, S-100 protein, myelin basic protein and lactate in CSF in dementiaQ48721686
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseasesQ48960752
Cerebrospinal fluid neuron-specific enolase: a further marker of Alzheimer's disease?Q49020317
CSF ubiquitin as a specific biomarker in Alzheimer's disease.Q50649289
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Q50940972
Cerebrospinal fluid biomarkers for Alzheimer’s disease: diagnostic performance in a homogeneous mono-center population.Q51020848
Increased Cerebrospinal Fluid Level of Insulin-like Growth Factor-II in Male Patients with Alzheimer's Disease.Q52148895
Cerebrospinal fluid neuron-specific enolase in Alzheimer's disease and vascular dementia.Q53202334
Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients.Q53235955
Ubiquitin is a component of paired helical filaments in Alzheimer's disease.Q53303482
Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimer's disease and frontotemporal lobar degeneration.Q53355443
S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in SwedenQ57248429
Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's diseaseQ57675752
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filamentsQ70462570
Neuron specific enolase in cerebrospinal fluid: a biochemical marker for neuronal degeneration in dementia disorders?Q72232429
Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practiceQ81366189
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcerebrospinal fluidQ54196
Alzheimer's diseaseQ11081
P304page(s)283-294
P577publication date2016-05-01
P1433published inDementia and geriatric cognitive disorders extraQ27723818
P1476titleIncreased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease
P478volume6

Reverse relations

cites work (P2860)
Q55437118A proteomic approach reveals the differential protein expression in Drosophila melanogaster treated with red ginseng extract (Panax ginseng).
Q37699616Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons
Q47708649Mass Spectrometric Analysis of Cerebrospinal Fluid Ubiquitin in Alzheimer's Disease and Parkinsonian Disorders
Q58697859Plasma Markers of Neurodegeneration Are Raised in Friedreich’s Ataxia
Q42369990The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer's and Vascular Disease

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