The beta subunit sliding DNA clamp is responsible for unassisted mutagenic translesion replication by DNA polymerase III holoenzyme

scientific article published on November 1998

The beta subunit sliding DNA clamp is responsible for unassisted mutagenic translesion replication by DNA polymerase III holoenzyme is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1998PNAS...9514106T
P356DOI10.1073/PNAS.95.24.14106
P932PMC publication ID24334
P698PubMed publication ID9826661
P5875ResearchGate publication ID13459394

P2093author name stringZ Livneh
G Tomer
N B Reuven
P2860cites workThree-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clampQ27642098
Thymine-thymine dimer bypass by yeast DNA polymerase zetaQ27938043
SOS-regulated proteins in translesion DNA synthesis and mutagenesisQ28271489
Mechanism of the sliding beta-clamp of DNA polymerase III holoenzymeQ28280243
Mutagenesis by apurinic/apyrimidinic sitesQ28300337
Bypass and termination at apurinic sites during replication of single-stranded DNA in vitro: a model for apurinic site mutagenesisQ33631558
DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machineQ34058015
Mechanism of mutation on DNA templates containing synthetic abasic sites: study with a double strand vectorQ34834214
Replication of UV-irradiated single-stranded DNA by DNA polymerase III holoenzyme of Escherichia coli: evidence for bypass of pyrimidine photodimersQ35613370
Mutation frequency and spectrum resulting from a single abasic site in a single-stranded vectorQ35837992
Mutational specificity of depurinationQ36252034
Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.Q36275662
Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase IIIQ37296938
DNA polymerase III holoenzyme. Components, structure, and mechanism of a true replicative complexQ37380733
Effect of single DNA lesions on in vitro replication with DNA polymerase III holoenzyme. Comparison with other polymerasesQ38311227
Escherichia coli single-stranded DNA-binding protein: multiple DNA-binding modes and cooperativitiesQ38312769
cis-syn thymine dimers are not absolute blocks to replication by DNA polymerase I of Escherichia coli in vitro.Q38342006
Mechanism of replication of ultraviolet-irradiated single-stranded DNA by DNA polymerase III holoenzyme of Escherichia coli. Implications for SOS mutagenesisQ38350743
Overproduction of the beta subunit of DNA polymerase III holoenzyme reduces UV mutagenesis in Escherichia coliQ39933704
Mutagenesis induced by single UV photoproducts in E. coli and yeastQ40486483
Replication of damaged DNA and the molecular mechanism of ultraviolet light mutagenesisQ40810156
Developmental control of cell cycle regulators: a fly's perspectiveQ41239581
PCNA: structure, functions and interactionsQ41351894
The role of exonucleolytic processing and polymerase-DNA association in bypass of lesions during replication in vitro. Significance for SOS-targeted mutagenesis.Q45900677
Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteinsQ46645542
Two binding modes in Escherichia coli single strand binding protein-single stranded DNA complexes. Modulation by NaCl concentration.Q52673770
Quantitation of the inhibition of Hfr x F- recombination by the mutagenesis complex UmuD'C.Q54562208
Purification of Escherichia coli DNA polymerase III holoenzyme.Q54619708
The appearance of the UmuD'C protein complex in Escherichia coli switches repair from homologous recombination to SOS mutagenesis.Q54647706
The beta subunit modulates bypass and termination at UV lesions during in vitro replication with DNA polymerase III holoenzyme of Escherichia coli.Q54727372
Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.Q54763221
Mutagenesis in vitro by depurination of ΦX174 DNAQ59093821
Chemical characterization and purification of the beta subunit of the DNA polymerase III holoenzyme from an overproducing strainQ68895639
The beta subunit dissociates readily from the Escherichia coli DNA polymerase III holoenzymeQ68929090
Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotidesQ70288775
Replication of O6-methylguanine-containing DNA by repair and replicative DNA polymerasesQ71246010
Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site-specific abasic lesionQ71265026
Mechanism of translesion DNA synthesis by DNA polymerase II. Comparison to DNA polymerases I and III coreQ71515081
Mechanism of bypass synthesis through an abasic site analog by DNA polymerase IQ73106783
Anti-mutagenic activity of DNA damage-binding proteins mediated by direct inhibition of translesion replicationQ73853915
The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutationsQ77231587
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)14106-14111
P577publication date1998-11-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe beta subunit sliding DNA clamp is responsible for unassisted mutagenic translesion replication by DNA polymerase III holoenzyme
P478volume95

Reverse relations

cites work (P2860)
Q33269165Analysis of environmental transcriptomes by DNA microarrays.
Q34323727Analysis of strand transfer and template switching mechanisms of DNA gap repair by homologous recombination in Escherichia coli: predominance of strand transfer
Q54516027Analysis of translesion replication across an abasic site by DNA polymerase IV of Escherichia coli
Q78482138Error-free recombinational repair predominates over mutagenic translesion replication in E. coli
Q79237484Involvement of DnaE, the Second Replicative DNA Polymerase from Bacillus subtilis, in DNA Mutagenesis
Q34385155Lesion bypass DNA polymerases replicate across non-DNA segments
Q54516425Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity.
Q73204355Lesion bypass by the Escherichia coli DNA polymerase V requires assembly of a RecA nucleoprotein filament
Q35265889Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA, and SSB
Q33694470Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis
Q34020161Quantitative measurement of translesion replication in human cells: evidence for bypass of abasic sites by a replicative DNA polymerase
Q38294175Single-stranded DNA-binding protein recruits DNA polymerase V to primer termini on RecA-coated DNA.
Q27621872Solution structure of the DNA decamer duplex containing a 3'-T x T basepair of the cis-syn cyclobutane pyrimidine dimer: implication for the mutagenic property of the cis-syn dimer
Q43567089The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions
Q27622171The Dewar photoproduct of thymidylyl(3'right-arrow5')- thymidine (Dewar product) exhibits mutagenic behavior in accordance with the"A rule"
Q33903483The SOS response regulates adaptive mutation
Q31422789The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replication

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