Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors

scientific article published on 9 December 2015

Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02529-15
P932PMC publication ID4810715
P698PubMed publication ID26656714

P2093author name stringFan Wu
Robert M Goeken
Vanessa M Hirsch
Jason M Brenchley
Alicia Buckler-White
Ilnour Ourmanov
Kenta Matsuda
Nadeene E Riddick
Sonya Whitted
Ronald J Plishka
Simoy Goldstein
P2860cites workCD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
Expression cloning of new receptors used by simian and human immunodeficiency virusesQ24318669
Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infectionQ24652969
Nonpathogenic simian immunodeficiency virus infectionsQ27004065
A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivoQ27313759
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infectionQ27318086
GPR15-mediated homing controls immune homeostasis in the large intestine mucosaQ28510063
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytesQ29619514
Going wild: lessons from naturally occurring T-lymphotropic lentivirusesQ31066870
Induction of AIDS by simian immunodeficiency virus from an African green monkey: species-specific variation in pathogenicity correlates with the extent of in vivo replicationQ33490135
Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infectionsQ33680743
Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS.Q33709283
Impact of viral factors on very early in vivo replication profiles in simian immunodeficiency virus SIVagm-infected African green monkeysQ33780668
Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing diseaseQ33782693
Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entryQ33787066
Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infectionQ33793153
Simian immunodeficiency viruses of diverse origin can use CXCR4 as a coreceptor for entry into human cellsQ33806017
Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection.Q33813926
Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaquesQ33826773
Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic diseaseQ33850643
Frequent substitution polymorphisms in African green monkey CCR5 cluster at critical sites for infections by simian immunodeficiency virus SIVagm, implying ancient virus-host coevolutionQ33854213
The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouseQ33916906
Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaquesQ33963994
Nonprogressive and progressive primate immunodeficiency lentivirus infectionsQ33996001
High levels of viral replication contrast with only transient changes in CD4(+) and CD8(+) cell numbers during the early phase of experimental infection with simian immunodeficiency virus SIVmnd-1 in Mandrillus sphinxQ34348128
Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaquesQ34382386
The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS.Q34413630
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.Q34445208
Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIVQ34482304
Primary simian immunodeficiency virus SIVmnd-2 infection in mandrills (Mandrillus sphinx).Q34545626
In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell declineQ35015256
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hostsQ35616028
Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expressionQ35658578
Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5.Q35665825
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.Q36399551
Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.Q36401180
Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesisQ36498174
Simian immunodeficiency virus SIVagm dynamics in African green monkeysQ36498208
Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencingQ36540055
The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infectionQ36548993
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeysQ36627986
Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulenceQ36631943
Species-specific diversity among simian immunodeficiency viruses from African green monkeysQ36692679
Simian immunodeficiency viruses from African green monkeys display unusual genetic diversityQ36802042
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infectionsQ36915902
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaquesQ37000791
Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infectionQ37033383
CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infectionQ37295552
Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN responseQ37452359
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeysQ37452365
Mosaic genome structure of simian immunodeficiency virus from west African green monkeysQ37633735
Identification of a new subgroup of SIVagm in tantalus monkeysQ38889785
The role of the alternative coreceptor GPR15 in SIV tropism for human cellsQ39300702
An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virusQ39581093
Early- and intermediate-stage variants of simian immunodeficiency virus replicate efficiently in cells lacking CCR5.Q39864177
Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytesQ40868880
An African green monkey lacking peripheral CD4 lymphocytes that retains helper T cell activity and coexists with SIVagmQ40932140
Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1.Q44533053
Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infectionQ45397778
Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteinsQ45753149
Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.Q45754230
Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV groupQ45832109
CD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infectionQ46180221
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremiaQ48023288
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural hostQ48078103
A new SIV co-receptor, STRL33.Q55067123
Intestinal inflammation, ileal structure and function in HIVQ57319333
Enteropathy associated with the acquired immunodeficiency syndromeQ70609075
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectSimian immunodeficiency virusQ1890246
P304page(s)2316-2331
P577publication date2015-12-09
P1433published inJournal of VirologyQ1251128
P1476titleSimian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors
P478volume90

Reverse relations

cites work (P2860)
Q39141518CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections.
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Q36950912Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys
Q52586058Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses.
Q55260301Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV Cure Strategies.
Q59358396Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques
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Q40619853The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression