A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo

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A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1001064
P3181OpenCitations bibliographic resource ID1257475
P932PMC publication ID2928783
P698PubMed publication ID20865163
P5875ResearchGate publication ID46414428

P50authorRonald G CollmanQ79946690
Donald L SodoraQ87838947
Mirko PaiardiniQ90797302
James G ElseQ115216156
Barbara CervasiQ115216167
Jessica C EngramQ115216171
Beatrice H. HahnQ55293537
Cristian ApetreiQ57442625
Guido SilvestriQ64578317
P2093author name stringYingying Li
Bing Li
Cynthia A Derdeyn
Lamorris M Loftin
Nadeene E Riddick
Jessica Taaffe
Emilia A Hermann
Winston C Wey
Sarah T Elliott
P2860cites workCD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hostsQ22251065
Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpzQ22251087
Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytesQ22251299
High Virus Loads in Naturally and Experimentally SIVagm-Infected African Green MonkeysQ22252842
Expression cloning of new receptors used by simian and human immunodeficiency virusesQ24318669
Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2.Q24533334
Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infectionQ24652969
Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalizationQ27318045
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infectionQ27318086
"Ground truth" for selection on CCR5-Delta32Q28238623
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor geneQ29614892
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infectionQ29614956
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infectionQ29619099
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infectionQ29619124
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytesQ29619514
Detection of the CCR5-Delta32 HIV resistance gene in Bronze Age skeletons.Q30350498
Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathwaysQ33504599
Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virusQ33782096
Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing diseaseQ33782693
Simian immunodeficiency viruses of diverse origin can use CXCR4 as a coreceptor for entry into human cellsQ33806017
Use of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and human immunodeficiency virus type 2 in primary cellsQ33808728
Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic diseaseQ33850643
A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activationQ33877335
Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstmQ33883874
The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouseQ33916906
Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations ofQ73848661
Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.Q45754230
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremiaQ48023288
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural hostQ48078103
An African primate lentivirus (SIVsm) closely related to HIV-2.Q48295012
Hybrid origin of SIV in chimpanzees.Q52842327
A new SIV co-receptor, STRL33.Q55067123
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural GeneQ56591978
The dynamics of CD4+ T-cell depletion in HIV diseaseQ33942992
Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut.Q33984007
Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates.Q34072857
Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaquesQ34382386
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.Q34445208
In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell declineQ35015256
Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1.Q35127334
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hostsQ35616028
Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entryQ35880381
In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaquesQ35919086
Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeysQ35947635
Understanding the benign nature of SIV infection in natural hostsQ36099429
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infectionQ36229666
Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligandsQ36296739
Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.Q36371505
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.Q36399551
Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.Q36401180
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeysQ36627986
Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulenceQ36631943
Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feedingQ36673279
Engineering human monoclonal antibody fragments: a recombinant enzyme-linked FabQ36686493
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infectionsQ36915902
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaquesQ37000791
Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN responseQ37452359
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeysQ37452365
Primary SIVsm isolates use the CCR5 coreceptor from sooty mangabeys naturally infected in west Africa: a comparison of coreceptor usage of primary SIVsm, HIV-2, and SIVmacQ38942816
Isolation of simian immunodeficiency viruses from two sooty mangabeys in Côte d'Ivoire: virological and genetic characterization and relationship to other HIV type 2 and SIVsm/mac strainsQ39346434
Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency virusesQ39413069
Early- and intermediate-stage variants of simian immunodeficiency virus replicate efficiently in cells lacking CCR5.Q39864177
Species selectivity of small-molecular antagonists for the CCR5 chemokine receptorQ40071154
Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): evolution of coreceptor use varies with pathogenic outcomeQ40316667
Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytesQ40868880
Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivoQ40923889
Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.Q41557849
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.Q41611623
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.Q43521980
Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency virusesQ45068171
Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infectionQ45397778
Pathogenesis of HIV infection: what the virus spares is as important as what it destroysQ45419109
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)e1001064
P577publication date2010-08-26
P1433published inPLOS PathogensQ283209
P1476titleA novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo
P478volume6

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