Coreceptor use in nonhuman primate models of HIV infection

scientific article published on 27 January 2011

Coreceptor use in nonhuman primate models of HIV infection is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1038012067
P356DOI10.1186/1479-5876-9-S1-S7
P932PMC publication ID3105507
P698PubMed publication ID21284906
P5875ResearchGate publication ID49801830

P2093author name stringCecilia Cheng-Mayer
Wuze Ren
Silvana Tasca Sina
P2860cites workCD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tractQ22242981
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells.Q51993308
Progressive infection in a subset of HIV-1-positive chimpanzees.Q52844171
Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDSQ52849903
Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs.Q53781127
High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinxQ56838018
Chimeric viruses between SIVmac and various HIV-1 isolates have biological properties that are similar to those of the parental HIV-1Q71746280
Association between CCR5 genotype and the clinical course of HIV-1 infectionQ73907325
Chemokine receptors and HIV entryQ74012124
Species tropism of chimeric SHIV clones containing HIV-1 subtype-A and subtype-E envelope genesQ74486151
An HIV-1-infected individual homozygous for the CCR-5 delta32 allele and the SDF-1 3'A alleleQ77310387
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hostsQ22251065
Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpzQ22251087
Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytesQ22251299
Classic AIDS in a sooty mangabey after an 18-year natural infectionQ24563966
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1Q24645530
Independent evolution of an antiviral TRIMCyp in rhesus macaquesQ24656091
HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptorsQ24682714
A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivoQ27313759
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinQ27860488
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humansQ28345408
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Evolution of a TRIM5-CypA splice isoform in old world monkeysQ28755216
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeysQ29547689
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and diseaseQ29616432
AIDS as a zoonosis: scientific and public health implicationsQ29617393
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesQ29619017
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infectionQ29619099
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infectionQ29619124
Infectious simian/human immunodeficiency virus with human immunodeficiency virus type 1 subtype C from an African isolate: rhesus macaque model.Q30329167
Going wild: lessons from naturally occurring T-lymphotropic lentivirusesQ31066870
Molecularly cloned SHIV-1157ipd3N4: a highly replication- competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env.Q33372270
Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infectionQ33382060
Induction of AIDS by simian immunodeficiency virus from an African green monkey: species-specific variation in pathogenicity correlates with the extent of in vivo replicationQ33490135
Different tempo and anatomic location of dual-tropic and X4 virus emergence in a model of R5 simian-human immunodeficiency virus infectionQ33558676
Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse modelQ33676640
Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B.Q33780595
Impact of viral factors on very early in vivo replication profiles in simian immunodeficiency virus SIVagm-infected African green monkeysQ33780668
Intestinal intraepithelial lymphocytes are primed for gamma interferon and MIP-1beta expression and display antiviral cytotoxic activity despite severe CD4(+) T-cell depletion in primary simian immunodeficiency virus infectionQ33783376
Loss of CD4+ T cells in human immunodeficiency virus type 1-infected chimpanzees is associated with increased lymphocyte apoptosisQ33783919
Evolution of syncytium-inducing and non-syncytium-inducing biological virus clones in relation to replication kinetics during the course of human immunodeficiency virus type 1 infection.Q33784321
Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32.Q33785711
Enhanced infectivity of an R5-tropic simian/human immunodeficiency virus carrying human immunodeficiency virus type 1 subtype C envelope after serial passages in pig-tailed macaques (Macaca nemestrina).Q33807885
Use of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and human immunodeficiency virus type 2 in primary cellsQ33808728
Simian-human immunodeficiency virus containing a human immunodeficiency virus type 1 subtype-E envelope gene: persistent infection, CD4(+) T-cell depletion, and mucosal membrane transmission in macaquesQ33810425
Characterization of a simian human immunodeficiency virus encoding the envelope gene from the CCR5-tropic HIV-1 Ba-L.Q39334360
The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cellsQ39438512
Infection and pathogenicity of chimeric simian-human immunodeficiency viruses in macaques: determinants of high virus loads and CD4 cell killingQ39457075
Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entryQ39464591
Heterogeneous spectrum of coreceptor usage among variants within a dualtropic human immunodeficiency virus type 1 primary-isolate quasispeciesQ39466299
Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infectionQ39597678
Rapid CD4(+) T-cell loss induced by human immunodeficiency virus type 1(NC) in uninfected and previously infected chimpanzeesQ39602019
Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitutionQ40060900
Evolution of the V3 envelope domain in proviral sequences and isolates of human immunodeficiency virus type 1 during transition of the viral biological phenotypeQ40066550
Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cellsQ40066880
Coreceptor change appears after immune deficiency is established in children infected with different HIV-1 subtypesQ40744358
T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropismQ40841237
The construction and evaluation of SIV/HIV chimeras that express the envelope of European HIV type 1 isolatesQ41105349
Fitness Disadvantage of Transitional Intermediates Contributes to Dynamic Change in the Infecting-Virus Population during Coreceptor Switch in R5 Simian/Human Immunodeficiency Virus-Infected MacaquesQ41230660
Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entryQ41583314
HIV entry and tropism: the chemokine receptor connection.Q41694886
Molecular cloning and in vitro evaluation of an infectious simian-human immunodeficiency virus containing env of a primary Chinese HIV-1 subtype C isolateQ45472501
Early viral load and CD4+ T cell count, but not percentage of CCR5+ or CXCR4+ CD4+ T cells, are associated with R5-to-X4 HIV type 1 virus evolutionQ45722973
Early immunologic events in mucosal and systemic lymphoid tissues after intrarectal inoculation with simian immunodeficiency virusQ45735523
Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hostsQ45762680
Human immunodeficiency virus infection and AIDS in a person with negative serologyQ45764049
Cell-mediated immune response toward viral envelope and core antigens in gibbon apes (Hylobates lar) chronically infected with human immunodeficiency virus-1.Q45832898
Identification and biologic characterization of an acutely lethal variant of simian immunodeficiency virus from sooty mangabeys (SIV/SMM).Q45843205
Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteinsQ45865515
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural hostQ48078103
An African primate lentivirus (SIVsm) closely related to HIV-2.Q48295012
Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate speciesQ36491115
Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralizationQ36635390
Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDSQ36654291
Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virusQ36673405
Mapping genetic determinants for human immunodeficiency virus type 1 resistance to soluble CD4Q36697574
Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 moleculeQ36697652
Emergence of a highly pathogenic simian/human immunodeficiency virus in a rhesus macaque treated with anti-CD8 mAb during a primary infection with a nonpathogenic virusQ36707305
R5X4 viruses are evolutionary, functional, and antigenic intermediates in the pathway of a simian-human immunodeficiency virus coreceptor switchQ36747765
Induction of simian AIDS in infant rhesus macaques infected with CCR5- or CXCR4-utilizing simian-human immunodeficiency viruses is associated with distinct lesions of the thymusQ36958820
Simian immunodeficiency virus SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through expanded coreceptor usage in vivoQ37275075
AIDS in african nonhuman primate hosts of SIVs: a new paradigm of SIV infectionQ37370335
Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical coursesQ37483781
Animal models of AIDS.Q38308877
Rapid CD4+ T-lymphocyte depletion in rhesus monkeys infected with a simian-human immunodeficiency virus expressing the envelope glycoproteins of a primary dual-tropic Ethiopian Clade C HIV type 1 isolateQ38935281
The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infectionQ38949380
Amino acid substitutions in the V3 loop are responsible for adaptation to growth in transformed T-cell lines of a primary human immunodeficiency virus type 1.Q39051222
Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1.Q39090313
The emergence and characterization of macrophage-tropic SIV/HIV chimeric viruses (SHIVs) present in CD4+ T cell-depleted rhesus monkeysQ39092739
Fatal immunopathogenesis by SIV/HIV-1 (SHIV) containing a variant form of the HIV-1SF33 env gene in juvenile and newborn rhesus macaquesQ39193008
The function of simian chemokine receptors in the replication of SIV.Q39221310
In vivo analysis of a new R5 tropic SHIV generated from the highly pathogenic SHIV-KS661, a derivative of SHIV-89.6.Q39225360
Co-receptors for HIV-1 entryQ39265878
Sequential turnover of human immunodeficiency virus type 1 env throughout the course of infectionQ39290859
Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infectionQ33825654
Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaquesQ33826773
Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4Q33851405
Pathogenicity of simian-human immunodeficiency virus SHIV-89.6P and SIVmac is attenuated in cynomolgus macaques and associated with early T-lymphocyte responsesQ33883896
A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progressionQ33980469
V3 loop-determined coreceptor preference dictates the dynamics of CD4+-T-cell loss in simian-human immunodeficiency virus-infected macaquesQ33984326
Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and preventionQ34050736
Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV)Q34060230
Developments in preclinical AIDS vaccine efficacy modelsQ34087058
Immunodeficiency in the absence of high viral load in pig-tailed macaques infected with Simian immunodeficiency virus SIVsun or SIVlhoestQ34124101
Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophagesQ34226885
Impact of MHC class I diversity on immune control of immunodeficiency virus replicationQ34235198
Molecular evolution of human immunodeficiency virus env in humans and monkeys: similar patterns occur during natural disease progression or rapid virus passageQ34338411
Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaquesQ34553778
Immunity in natural SIV infectionsQ34602157
Non-human primate models for AIDS vaccine researchQ34715769
Lessons learned from the natural hosts of HIV-related virusesQ34993932
Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switchingQ35122466
Simian AIDS: an historical perspectiveQ35537961
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hostsQ35616028
Increased neutralization sensitivity of recently emerged CXCR4-using human immunodeficiency virus type 1 strains compared to coexisting CCR5-using variants from the same patient.Q35634988
The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infectionQ35682491
Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutationsQ35785164
The roles of nonhuman primates in the preclinical evaluation of candidate AIDS vaccinesQ35851774
Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.Q35857688
Chimeric simian/human immunodeficiency virus that causes progressive loss of CD4+ T cells and AIDS in pig-tailed macaquesQ35860556
A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.Q35870467
Human immunodeficiency virus type 1 genetic evolution in children with different rates of development of diseaseQ35875709
Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responsesQ35886136
Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaquesQ35947758
The HIV coreceptor switch: a population dynamical perspectiveQ36152173
Novel TRIM5 isoforms expressed by Macaca nemestrinaQ36315442
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.Q36399551
Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.Q36401180
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P921main subjectmembrane proteinQ423042
viral proteinQ952587
cell surface receptorQ2476074
virusQ808
HIVQ15787
viral envelope proteinsQ66008752
virus receptorsQ66053321
hemic and immune systemsQ70202933
P304page(s)S7
P577publication date2011-01-27
P1433published inJournal of Translational MedicineQ15716664
P1476titleCoreceptor use in nonhuman primate models of HIV infection
P478volume9 Suppl 1