| scholarly article | Q13442814 |
| P50 | author | Huan Cai | Q37375202 |
| P2093 | author name string | Feng Liu | |
| Lily Q Dong | |||
| P2860 | cites work | Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue | Q40693029 |
| mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes. | Q41441726 | ||
| A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals | Q41488066 | ||
| Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons | Q41774391 | ||
| Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 | Q41983843 | ||
| On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake | Q42017519 | ||
| Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease | Q42734497 | ||
| Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration | Q42805718 | ||
| Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes | Q42806267 | ||
| Feedback regulation of mTORC1 by Grb10 in metabolism and beyond | Q43207787 | ||
| Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes. | Q44185388 | ||
| Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies | Q45067792 | ||
| Sympathetic activation of glucose utilization in brown adipose tissue in rats | Q51608809 | ||
| Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus | Q53833860 | ||
| Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch. | Q54323020 | ||
| Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation. | Q55071882 | ||
| Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin | Q60714047 | ||
| The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation | Q40531189 | ||
| Activation of mTORC2 by Association with the Ribosome | Q24294876 | ||
| Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids | Q24306330 | ||
| SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth | Q24309283 | ||
| S6K1 plays a critical role in early adipocyte differentiation | Q24594058 | ||
| Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity | Q24598427 | ||
| Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism | Q24608263 | ||
| Identification and importance of brown adipose tissue in adult humans | Q24632425 | ||
| Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology | Q24634012 | ||
| mTOR signaling in growth control and disease | Q24634174 | ||
| The cell biology of fat expansion | Q28084054 | ||
| Shades of brown: a model for thermogenic fat | Q28085301 | ||
| Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 | Q28181376 | ||
| Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan | Q28244634 | ||
| Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks | Q28255399 | ||
| TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth | Q28262401 | ||
| BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation | Q28282926 | ||
| Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction | Q28304066 | ||
| Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway | Q28505405 | ||
| Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria | Q28506657 | ||
| The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins | Q28507365 | ||
| Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2 | Q28511429 | ||
| Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation | Q28583021 | ||
| Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis | Q28595034 | ||
| Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 | ||
| Activation of a metabolic gene regulatory network downstream of mTOR complex 1 | Q29615179 | ||
| Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human | Q29617382 | ||
| Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes | Q30301274 | ||
| Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation | Q30418348 | ||
| Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue | Q30419099 | ||
| mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway | Q30425628 | ||
| Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway | Q33480974 | ||
| Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes | Q33673780 | ||
| Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis | Q33734679 | ||
| Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage | Q33750671 | ||
| Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. | Q33780305 | ||
| FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases | Q33851027 | ||
| PPARγ and the global map of adipogenesis and beyond | Q33924305 | ||
| The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. | Q33928657 | ||
| Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. | Q34031152 | ||
| Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. | Q34060841 | ||
| Chronic rapamycin treatment causes diabetes in male mice | Q34062932 | ||
| Tissue-specific insulin signaling in the regulation of metabolism and aging | Q34076176 | ||
| The forkhead transcription factor Foxo1 regulates adipocyte differentiation | Q34170890 | ||
| Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. | Q34244082 | ||
| Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c | Q34269920 | ||
| Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity | Q34275062 | ||
| DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. | Q34293348 | ||
| Brown and beige fat: development, function and therapeutic potential | Q34375850 | ||
| Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. | Q34456901 | ||
| Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation | Q34483836 | ||
| Growing knowledge of the mTOR signaling network | Q34620724 | ||
| Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy | Q34891582 | ||
| Development of organometallic S6K1 inhibitors | Q34891733 | ||
| Activated type 2 innate lymphoid cells regulate beige fat biogenesis | Q34979492 | ||
| mTOR complex 2 in adipose tissue negatively controls whole-body growth | Q34985009 | ||
| Sirolimus: its discovery, biological properties, and mechanism of action | Q35125746 | ||
| Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling | Q35370616 | ||
| The brown fat secretome: metabolic functions beyond thermogenesis | Q35561612 | ||
| Genetic variation in the raptor gene is associated with overweight but not hypertension in American men of Japanese ancestry | Q35588195 | ||
| Intracerebroventricular administration of leptin increase physical activity but has no effect on thermogenesis in cold-acclimated rats | Q35693468 | ||
| 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL | Q35837163 | ||
| Expanding roles for SREBP in metabolism | Q36303731 | ||
| The multifaceted role of mTORC1 in the control of lipid metabolism | Q36659049 | ||
| Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. | Q36765385 | ||
| mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer | Q36798847 | ||
| Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice | Q36857264 | ||
| Rapamycin: something old, something new, sometimes borrowed and now renewed | Q36922923 | ||
| Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2) | Q36939696 | ||
| Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling | Q37163024 | ||
| Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. | Q37314990 | ||
| What we talk about when we talk about fat. | Q37601812 | ||
| Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations | Q37610497 | ||
| An emerging role of mTOR in lipid biosynthesis. | Q37641438 | ||
| Rapamycin: one drug, many effects | Q37679469 | ||
| Mammalian TOR signaling to the AGC kinases | Q37943416 | ||
| mTOR in aging, metabolism, and cancer | Q38073906 | ||
| Role of energy‐ and nutrient‐sensing kinases AMP‐activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in Adipocyte Differentiation | Q38106669 | ||
| A Central role for mTOR in lipid homeostasis | Q38131225 | ||
| Brown fat fuel utilization and thermogenesis | Q38175686 | ||
| Making new contacts: the mTOR network in metabolism and signalling crosstalk | Q38189969 | ||
| Current treatment strategies for inhibiting mTOR in cancer | Q38286529 | ||
| From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century | Q38286539 | ||
| Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation | Q38302018 | ||
| mTOR signaling in cellular and organismal energetics | Q38305897 | ||
| Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes | Q38324561 | ||
| Adipokines in health and disease | Q38507006 | ||
| The role of mTOR in lipid homeostasis and diabetes progression | Q38560473 | ||
| Induction of thermogenesis in brown and beige adipose tissues: molecular markers, mild cold exposure and novel therapies | Q38575092 | ||
| A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation | Q38847141 | ||
| Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability | Q39129297 | ||
| Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. | Q39150466 | ||
| YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29 | Q39246531 | ||
| Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). | Q39668305 | ||
| PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts | Q40316335 | ||
| Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. | Q40480010 | ||
| regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis | Q40499939 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 303-317 | |
| P577 | publication date | 2015-12-14 | |
| P1433 | published in | Trends in Pharmacological Sciences | Q2451474 |
| P1476 | title | Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects | |
| P478 | volume | 37 |
| Q64117196 | -Cinnamic Acid Stimulates White Fat Browning and Activates Brown Adipocytes |
| Q52720323 | Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor |
| Q54116659 | Adipocyte-specific deletion of Lkb1 and mTOR protects against high-fat diet induced obesity but results in insulin resistance. |
| Q37729425 | Alcohol, Adipose Tissue and Lipid Dysregulation |
| Q41637054 | Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function |
| Q61444249 | ENOblock inhibits the pathology of diet-induced obesity |
| Q98891875 | Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes |
| Q37744874 | Enhanced expression of Survivin has distinct roles in adipocyte homeostasis |
| Q55410665 | Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins. |
| Q33634707 | Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals |
| Q37070858 | Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis |
| Q36880550 | Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain. |
| Q26739857 | Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism |
| Q38650511 | Interleukin-15 in obesity and metabolic dysfunction: current understanding and future perspectives. |
| Q47755607 | Key factors involved in obesity development |
| Q92537523 | Leptin Induces Proadipogenic and Proinflammatory Signaling in Adipocytes |
| Q50426370 | Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome. |
| Q91899278 | Mammalian Target of Rapamycin: A Metabolic Rheostat for Regulating Adipose Tissue Function and Cardiovascular Health |
| Q91721074 | Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis |
| Q61808034 | Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator |
| Q57464348 | New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques |
| Q64067884 | Obesity May Accelerate the Aging Process |
| Q89511653 | Pleiotropic Biological Effects of Dietary Phenolic Compounds and their Metabolites on Energy Metabolism, Inflammation and Aging |
| Q51281097 | Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice. |
| Q92904617 | Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway |
| Q60920829 | Salt Induces Adipogenesis/Lipogenesis and Inflammatory Adipocytokines Secretion in Adipocytes |
| Q49921559 | Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions |
| Q64256257 | The Cutting Edge: The Role of mTOR Signaling in Laminopathies |
| Q93271525 | The Influence of Metformin to the Transcriptional Activity of the mTOR and FOX3 Genes in Parapancreatic Adipose Tissue of Streptozotocin-Induced Diabetic Rats |
| Q88640356 | Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain |
| Q91286750 | iTRAQ-Based Quantitative Proteomic Comparison of 2D and 3D Adipocyte Cell Models Co-cultured with Macrophages Using Online 2D-nanoLC-ESI-MS/MS |
| Q59350248 | mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans |
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