Differential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo

scientific article published on 15 January 2013

Differential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MT.2012.277
P932PMC publication ID3616533
P698PubMed publication ID23319058

P2093author name stringTerry K Bertin
Brendan Lee
Irene Zolotukhin
Roland W Herzog
Masataka Suzuki
Donna J Palmer
Philip Ng
Geoffrey L Rogers
Racel G Cela
P2860cites workLong-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirusQ45036081
Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirusQ45269052
The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liverQ45396033
Improved hepatic transduction, reduced systemic vector dissemination, and long-term transgene expression by delivering helper-dependent adenoviral vectors into the surgically isolated liver of nonhuman primates.Q45857353
In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.Q45864497
Pseudo-hydrodynamic delivery of helper-dependent adenoviral vectors into non-human primates for liver-directed gene therapy.Q45865772
Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivoQ45867544
Correction of murine hemophilia A and immunological differences of factor VIII variants delivered by helper-dependent adenoviral vectorsQ45870948
Transcriptionally active drugs improve adenovirus vector performance in vitro and in vivoQ45872399
A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivoQ45877084
Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylationQ46423291
Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivoQ64376599
Early STAT1 activation after systemic delivery of HSV amplicon vectors suppresses transcription of the vector-encoded transgeneQ80674687
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathwayQ24317317
Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vectorQ24555782
Differential activation of innate immune responses by adenovirus and adeno-associated virus vectorsQ24673796
Coagulation factor X activates innate immunity to human species C adenovirusQ27332110
Interferon-inducible antiviral effectorsQ27486790
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated functionQ29617462
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune responseQ29620414
Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.Q33337331
A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiencyQ33340517
Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A modelQ33371228
Modulation of TNFalpha, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectorsQ33371239
Large-scale production of high-quality helper-dependent adenoviral vectors using adherent cells in cell factoriesQ33691820
Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primatesQ33713289
ICP0 inhibits the decrease of HSV amplicon-mediated transgene expressionQ33713413
MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to helper-dependent adenovirus.Q33832157
Role and fate of PML nuclear bodies in response to interferon and viral infectionsQ34435571
Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complementQ34597583
RETRACTED: Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapyQ34621544
Species differences in the pharmacology and toxicology of PEGylated helper-dependent adenovirusQ34975214
The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liverQ35067592
NOD2 signaling contributes to the innate immune response against helper-dependent adenovirus vectors independently of MyD88 in vivo.Q35226121
Adenovirus-associated virus vector-mediated gene transfer in hemophilia BQ35691659
Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathwaysQ35785201
PML and PML nuclear bodies: implications in antiviral defenceQ36753891
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in miceQ37286686
Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challengesQ37866086
Immune responses to AAV in clinical trialsQ37873955
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligandsQ39791660
Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatinQ40304976
Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vectorQ40619684
Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivoQ40883683
Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivoQ40957520
Host cell detection of noncoding stuffer DNA contained in helper-dependent adenovirus vectors leads to epigenetic repression of transgene expressionQ42002320
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivoQ42579980
Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA.Q42804321
Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors.Q44592739
A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells.Q44662326
Antigen-specific tolerance of human alpha1-antitrypsin induced by helper-dependent adenovirusQ44663072
Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectorsQ44688725
P433issue4
P921main subjectAdenoviridaeQ193447
P304page(s)796-805
P577publication date2013-01-15
P1433published inMolecular TherapyQ15762400
P1476titleDifferential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo
P478volume21

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