Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex

scientific article published on 19 January 2016

Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.681031
P932PMC publication ID4813578
P698PubMed publication ID26786106

P50authorJennifer L. RossQ40277508
Alejandro P HeuckQ47093651
Kyle C RossiQ87114156
P2093author name stringFabian B Romano
Yuzhou Tang
Kathryn R Monopoli
P2860cites workStructural insights into the assembly of the type III secretion needle complex.Q24547949
Assembly of β-barrel proteins into bacterial outer membranesQ26998912
The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cellsQ27318175
Three-dimensional model of Salmonella's needle complex at subnanometer resolutionQ27666889
Enzymatic assembly of DNA molecules up to several hundred kilobasesQ28241142
Protein delivery into eukaryotic cells by type III secretion machinesQ28276443
The type III secretion injectisomeQ29617944
Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysinsQ30153399
Tethered polymer-supported planar lipid bilayers for reconstitution of integral membrane proteins: silane-polyethyleneglycol-lipid as a cushion and covalent linkerQ30306022
Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophagesQ30525355
Efficient isolation of Pseudomonas aeruginosa type III secretion translocators and assembly of heteromeric transmembrane pores in model membranesQ33965276
Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells.Q34001022
The type III secretion system tip complex and translocon.Q34011259
Theory and application of fluorescence homotransfer to melittin oligomerizationQ34047406
Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranesQ34048607
Influence of oligomerization state on the structural properties of invasion plasmid antigen B from Shigella flexneri in the presence and absence of phospholipid membranes.Q34389407
Salmonella interactions with host cells: type III secretion at workQ34425135
Supported phospholipid bilayersQ34535418
The Yersinia Ysc-Yop 'type III' weaponryQ34931776
Drosophila katanin-60 depolymerizes and severs at microtubule defectsQ34978156
Mechanisms of integral membrane protein insertion and foldingQ35118815
The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner.Q35574660
Enumeration of oligomerization states of membrane proteins in living cells by homo-FRET spectroscopy and microscopy: theory and applicationQ35751501
Fluorescence quenching: A tool for single-molecule protein-folding studyQ35839147
Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteinsQ36059050
Piecing together the type III injectisome of bacterial pathogensQ37079418
Multiple color single molecule TIRF imaging and tracking of MAPs and motorsQ37751246
Membrane targeting and pore formation by the type III secretion system transloconQ37823656
Deciphering the subunit composition of multimeric proteins by counting photobleaching stepsQ38183701
Membrane pore formation at protein-lipid interfacesQ38273877
Comparison of membrane insertion pathways of the apoptotic regulator Bcl-xL and the diphtheria toxin translocation domainQ39077541
Shigella effector IpaB-induced cholesterol relocation disrupts the Golgi complex and recycling network to inhibit host cell secretionQ39278546
Single molecule fluorescence study of the Bacillus thuringiensis toxin Cry1Aa reveals tetramerizationQ39712066
Oligomerization of type III secretion proteins PopB and PopD precedes pore formation in PseudomonasQ39927824
SipC multimerization promotes actin nucleation and contributes to Salmonella-induced inflammationQ40051422
IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes.Q40454544
Pseudomonas aeruginosa mediated apoptosis requires the ADP-ribosylating activity of exoS.Q40850862
The V antigen of Pseudomonas aeruginosa is required for assembly of the functional PopB/PopD translocation pore in host cell membranesQ41195095
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needlesQ41456399
Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranesQ41458033
IpaC from Shigella and SipC from Salmonella possess similar biochemical properties but are functionally distinctQ41474021
Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosisQ41484833
N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD.Q41785011
Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction.Q42128361
Structure of a pathogenic type 3 secretion system in actionQ42237643
Characterization of molten globule PopB in absence and presence of its chaperone PcrH.Q43422418
Dimers of dipyrrometheneboron difluoride (BODIPY) with light spectroscopic applications in chemistry and biologyQ43848399
Analyzing topography of membrane-inserted diphtheria toxin T domain using BODIPY-streptavidin: at low pH, helices 8 and 9 form a transmembrane hairpin but helices 5-7 form stable nonclassical inserted segments on the cis side of the bilayerQ44974409
The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topologyQ48555964
The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.Q53575352
Construction of Actinobacillus pleuropneumoniae-Escherichia coli shuttle vectors: expression of antibiotic-resistance genes.Q54167819
Synergistic Pore Formation by Type III Toxin Translocators ofPseudomonas aeruginosa†Q57365041
Membrane Protein Stoichiometry Determined from the Step-Wise Photobleaching of Dye-Labelled SubunitsQ57909264
Type III secretion system translocator has a molten globule conformation both in its free and chaperone-bound formsQ60526653
A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin AQ68065183
Oligomeric structure of P-type ATPases observed by single molecule detection techniqueQ73430547
Identification of shallow and deep membrane-penetrating forms of diphtheria toxin T domain that are regulated by protein concentration and bilayer widthQ73735548
Membrane protein insertion regulated by bringing electrostatic and hydrophobic interactions into play. A case study with the translocation domain of diphtheria toxinQ74650029
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
P304page(s)6304-6315
P577publication date2016-01-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleType 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex
P478volume291

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cites work (P2860)
Q39230405Assembly, structure, function and regulation of type III secretion systems.
Q90170341On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome
Q88446234The Pseudomonas aeruginosa type III secretion translocator PopB assists the insertion of the PopD translocator into host cell membranes
Q57036091Visualization of the type III secretion mediated -host cell interface using cryo-electron tomography
Q60934153Visualization of translocons in Yersinia type III protein secretion machines during host cell infection

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