The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles

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The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles is …
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scholarly articleQ13442814

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P819ADS bibcode2005Sci...310..674M
P356DOI10.1126/SCIENCE.1118476
P698PubMed publication ID16254184

P50authorPetr BrozQ37378371
P2093author name stringGuy R Cornelis
Isabel Sorg
Andreas Engel
Shirley A Müller
Philippe Ringler
Catherine A Mueller
Françoise Erne-Brand
Marina Kuhn
P433issue5748
P407language of work or nameEnglishQ1860
P304page(s)674-676
P577publication date2005-10-01
P1433published inScienceQ192864
P1476titleThe V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles
P478volume310

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cites work (P2860)
Q41435019A dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia
Q36833082A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact
Q39028285A recombinant bivalent fusion protein rVE confers active and passive protection against Yersinia enterocolitica infection in mice
Q38127453A sophisticated multi-step secretion mechanism: how the type 3 secretion system is regulated
Q37673260Adhesive organelles of Gram-negative pathogens assembled with the classical chaperone/usher machinery: structure and function from a clinical standpoint
Q33636983Amino acid and structural variability of Yersinia pestis LcrV protein.
Q33653622Amino acid residues 196-225 of LcrV represent a plague protective epitope
Q41380601Anti-PcrV antibody strategies against virulent Pseudomonas aeruginosa
Q38366322Approaches targeting the type III secretion system to treat or prevent bacterial infections
Q37230906Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria
Q41411817Assembly of the Yersinia injectisome: the missing pieces.
Q38183945Assembly of the bacterial type III secretion machinery.
Q33238585Assembly of the type III secretion apparatus of enteropathogenic Escherichia coli
Q39230405Assembly, structure, function and regulation of type III secretion systems.
Q34142106Bacterial nanomachines: the flagellum and type III injectisome.
Q58792122Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells
Q27028058Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells
Q53028079Binding mode analysis of a major T3SS translocator protein PopB with its chaperone PcrH from Pseudomonas aeruginosa.
Q28484742Bioinformatic and biochemical evidence for the identification of the type III secretion system needle protein of Chlamydia trachomatis
Q34851073Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip protein
Q39177635Biophysical characterization of the type III secretion tip proteins and the tip proteins attached to bacterium-like particles
Q33590435Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN
Q43422418Characterization of molten globule PopB in absence and presence of its chaperone PcrH.
Q30428389Characterization of the interaction between the Salmonella type III secretion system tip protein SipD and the needle protein PrgI by paramagnetic relaxation enhancement
Q36388232Conformational stability and differential structural analysis of LcrV, PcrV, BipD, and SipD from type III secretion systems
Q35071514Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV.
Q27671650Crystal Structure of PrgI-SipD: Insight into a Secretion Competent State of the Type Three Secretion System Needle Tip and its Interaction with Host Ligands
Q30481246Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella
Q80295328Deadly plague versus mild-mannered TLR4
Q30494891Deciphering the assembly of the Yersinia type III secretion injectisome
Q92726819Development of a multiple-antigen protein fusion vaccine candidate that confers protection against Bacillus anthracis and Yersinia pestis
Q35783560Development of in vitro correlate assays of immunity to infection with Yersinia pestis.
Q33388949Differentially evolved genes of Salmonella pathogenicity islands: insights into the mechanism of host specificity in Salmonella
Q36315321Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence
Q33601814Direct neutralization of type III effector translocation by the variable region of a monoclonal antibody to Yersinia pestis LcrV
Q37450884Dual-function antibodies to Yersinia pestis LcrV required for pulmonary clearance of plague
Q33965276Efficient isolation of Pseudomonas aeruginosa type III secretion translocators and assembly of heteromeric transmembrane pores in model membranes
Q90186755Epidemiological survey of serum titers from adults against various Gram-negative bacterial V-antigens
Q35913680Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis
Q30481673ExoS controls the cell contact-mediated switch to effector secretion in Pseudomonas aeruginosa
Q35970485Expression and Association of the Yersinia pestis Translocon Proteins, YopB and YopD, Are Facilitated by Nanolipoprotein Particles
Q41429434Expression hierarchy in the Yersinia type III secretion system established through YopD recognition of RNA
Q35846730Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system
Q41448848Extracytoplasmic-stress-responsive pathways modulate type III secretion in Yersinia pseudotuberculosis
Q36852090FGL chaperone-assembled fimbrial polyadhesins: anti-immune armament of Gram-negative bacterial pathogens
Q90168522FPR1 is the plague receptor on host immune cells
Q33877252Fine-tuning synthesis of Yersinia pestis LcrV from runaway-like replication balanced-lethal plasmid in a Salmonella enterica serovar typhimurium vaccine induces protection against a lethal Y. pestis challenge in mice
Q41432317Formulation and Immunogenicity of a Potential Multivalent Type III Secretion System-Based Protein Vaccine
Q41447558Function and molecular architecture of the Yersinia injectisome tip complex
Q39192014Functional insights into the Shigella type III needle tip IpaD in secretion control and cell contact.
Q38725248Functional relatedness in the Inv/Mxi-Spa type III secretion system family
Q26995596Förster resonance energy transfer (FRET) as a tool for dissecting the molecular mechanisms for maturation of the Shigella type III secretion needle tip complex
Q42736388Genetic Dissection of the Signaling Cascade that Controls Activation of the Shigella Type III Secretion System from the Needle Tip.
Q40710120Genome Sequence of the Fish Pathogen Yersinia ruckeri SC09 Provides Insights into Niche Adaptation and Pathogenic Mechanism
Q33691879Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis
Q35913579Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10.
Q36410035Hereditary hemochromatosis restores the virulence of plague vaccine strains
Q54242376Heterologous Complementation Studies With the YscX and YscY Protein Families Reveals a Specificity for Yersinia pseudotuberculosis Type III Secretion.
Q33304193High throughput screening for small-molecule inhibitors of type III secretion in Yersinia pestis
Q33778441Hijacking of the pleiotropic cytokine interferon-γ by the type III secretion system of Yersinia pestis
Q34660429How the structural gene products of Yersinia pestis relate to virulence
Q28748886Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model
Q41437305Humoral immune responses and protective efficacy of sequential B- and T-cell epitopes of V antigen of Yersinia pestis by intranasal immunization in microparticles
Q33585993Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis
Q41446450Identification of TyeA residues required to interact with YopN and to regulate Yop secretion
Q35111099Identification of mammalian proteins that collaborate with type III secretion system function: involvement of a chemokine receptor in supporting translocon activity
Q34562642Identification of novel protein-protein interactions of Yersinia pestis type III secretion system by yeast two hybrid system
Q42518529Identification of the MxiH needle protein residues responsible for anchoring invasion plasmid antigen D to the type III secretion needle tip.
Q41445750Identifying B and T cell epitopes and studying humoral, mucosal and cellular immune responses of peptides derived from V antigen of Yersinia pestis
Q41389173Immunization with a DNA adenine methylase over-producing Yersinia pseudotuberculosis vaccine confers robust cross-protection against heterologous pathogenic serotypes.
Q36974485Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague
Q36898369Impassable YscP substrates and their impact on the Yersinia enterocolitica type III secretion pathway.
Q92893241Improved production of monoclonal antibodies against the LcrV antigen of Yersinia pestis using FACS-aided hybridoma selection
Q33483363In vitro intracellular trafficking of virulence antigen during infection by Yersinia pestis.
Q30973404Innate immune recognition of Yersinia pseudotuberculosis type III secretion
Q35096231Interactions and predicted host membrane topology of the enteropathogenic Escherichia coli translocator protein EspB
Q40454924Introduction to Type III Secretion Systems.
Q41856079IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri
Q38282188Key steps in type III secretion system (T3SS) towards translocon assembly with potential sensor at plant plasma membrane.
Q36581211LcrV mutants that abolish Yersinia type III injectisome function
Q34068346Length control of the injectisome needle requires only one molecule of Yop secretion protein P (YscP).
Q90400965Life After Secretion-Yersinia enterocolitica Rapidly Toggles Effector Secretion and Can Resume Cell Division in Response to Changing External Conditions
Q36960814Lipid A mimetics are potent adjuvants for an intranasal pneumonic plague vaccine
Q38667595Lytic transglycosylases: concinnity in concision of the bacterial cell wall
Q35073938Measurement of effector protein injection by type III and type IV secretion systems by using a 13-residue phosphorylatable glycogen synthase kinase tag
Q27680731Membrane and Chaperone Recognition by the Major Translocator Protein PopB of the Type III Secretion System of Pseudomonas aeruginosa
Q37823656Membrane targeting and pore formation by the type III secretion system translocon
Q28492629Modified needle-tip PcrV proteins reveal distinct phenotypes relevant to the control of type III secretion and intoxication by Pseudomonas aeruginosa
Q33553003Molecular architecture of Streptococcus pneumoniae TIGR4 pili
Q24670035Molecular model of a type III secretion system needle: Implications for host-cell sensing
Q30431366Multi-Functional Characteristics of the Pseudomonas aeruginosa Type III Needle-Tip Protein, PcrV; Comparison to Orthologs in other Gram-negative Bacteria
Q40214494Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells
Q42713418N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins
Q41785011N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD.
Q39794212N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection
Q42126458NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile salts
Q41838952NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system
Q40008433Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague
Q40451950Oligomerization of PcrV and LcrV, protective antigens of Pseudomonas aeruginosa and Yersinia pestis.
Q84740727Plague
Q34805666Plague in Guinea pigs and its prevention by subunit vaccines
Q38612499Plague: Infections of Companion Animals and Opportunities for Intervention
Q37150791Pneumonic plague pathogenesis and immunity in Brown Norway rats
Q35867550Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunity
Q37745002Predictive models and correlates of protection for testing biodefence vaccines
Q36513899Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines
Q38131537Prophylaxis and therapy of plague
Q26823422Protecting against plague: towards a next-generation vaccine
Q33487545Protection against anthrax and plague by a combined vaccine in mice and rabbits
Q37190877Protective immunity in mice achieved with dry powder formulation and alternative delivery of plague F1-V vaccine
Q28276443Protein delivery into eukaryotic cells by type III secretion machines
Q30318075Protein export according to schedule: architecture, assembly, and regulation of type III secretion systems from plant- and animal-pathogenic bacteria
Q27662205Protein refolding is required for assembly of the type three secretion needle
Q37332326Protein secretion and membrane insertion systems in bacteria and eukaryotic organelles
Q28501148Protein-protein interactions within type III secretion system-dependent pili of Rhizobium sp. strain NGR234
Q41525965PscI is a type III secretion needle anchoring protein with in vitro polymerization capacities.
Q37688618Rational considerations about development of live attenuated Yersinia pestis vaccines
Q40463683Reassessment of MxiH subunit orientation and fold within native Shigella T3SS needles using surface labelling and solid-state NMR.
Q33996241Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems.
Q38079815Regulation of the Yersinia type III secretion system: traffic control
Q28493109Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa
Q35671570Resistance to Yersinia pestis infection decreases with age in B10.T(6R) mice
Q36804646RfaL is required for Yersinia pestis type III secretion and virulence
Q41307994Role of host cell polarity and leading edge properties in Pseudomonas type III secretion
Q36984033Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.
Q37416226Secretion by numbers: Protein traffic in prokaryotes
Q35133886Secretion signal recognition by YscN, the Yersinia type III secretion ATPase.
Q35846739Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.
Q42128393Shigella IpaD has a dual role: signal transduction from the type III secretion system needle tip and intracellular secretion regulation.
Q36190614Site-Directed Mutagenesis and Its Application in Studying the Interactions of T3S Components.
Q41439298Small protective fragments of the Yersinia pestis V antigen
Q57048274SsaV Interacts with SsaL to Control the Translocon-to-Effector Switch in the SPI-2 Type Three Secretion System
Q27660501Structural Basis of Chaperone Recognition of Type III Secretion System Minor Translocator Proteins
Q40435679Structural analysis of inter-genus complexes of V-antigen and its regulator and their stabilization by divalent metal ions
Q28732757Structural characterization of a novel Chlamydia pneumoniae type III secretion-associated protein, Cpn0803
Q37460910Structural dissection of the extracellular moieties of the type III secretion apparatus
Q37812889Structural overview of the bacterial injectisome
Q37014297Structure and biophysics of type III secretion in bacteria
Q27340227Structure of a bacterial type III secretion system in contact with a host membrane in situ
Q38006509Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function
Q41427637T cells play an essential role in anti-F1 mediated rapid protection against bubonic plague
Q41400721TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica.
Q30485605Targeting type III secretion in Yersinia pestis
Q34313640Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia
Q40403205The Amino-Terminal Part of the Needle-Tip Translocator LcrV of Yersinia pseudotuberculosis Is Required for Early Targeting of YopH and In vivo Virulence
Q33502747The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complex
Q64075941The Injectisome, a Complex Nanomachine for Protein Injection into Mammalian Cells
Q40640251The LcrG Tip Chaperone Protein of the Yersinia pestis Type III Secretion System Is Partially Folded.
Q26767237The Many Faces of IpaB
Q47744378The Pseudomonas syringae HrpJ protein controls the secretion of type III translocator proteins and has a virulence role inside plant cells
Q28073674The Structure and Function of Type III Secretion Systems
Q35972461The Type III Secretion Translocation Pore Senses Host Cell Contact.
Q38160403The Yersinia pestis type III secretion system: expression, assembly and role in the evasion of host defenses
Q49837446The YscE/YscG chaperone and YscF N-terminal sequences target YscF to the Yersinia pestis type III secretion apparatus.
Q41425944The assembly of the export apparatus (YscR,S,T,U,V) of the Yersinia type III secretion apparatus occurs independently of other structural components and involves the formation of an YscV oligomer.
Q37993038The blueprint of the type-3 injectisome
Q28488627The common structural architecture of Shigella flexneri and Salmonella typhimurium type three secretion needles
Q27665429The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate
Q34767708The discovery of SycO highlights a new function for type III secretion effector chaperones.
Q39896038The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding.
Q41447968The fraction 1 and V protein antigens of Yersinia pestis activate dendritic cells to induce primary T cell responses
Q36211081The hydrophilic translocator for Vibrio parahaemolyticus, T3SS2, is also translocated
Q38589273The role of immune correlates and surrogate markers in the development of vaccines and immunotherapies for plague
Q29617944The type III secretion injectisome
Q37756149The type III secretion injectisome, a complex nanomachine for intracellular 'toxin' delivery
Q37397923The type III secretion system of Pseudomonas aeruginosa: infection by injection
Q34011259The type III secretion system tip complex and translocon.
Q42566246Three-dimensional electron microscopy reconstruction and cysteine-mediated crosslinking provide a model of the type III secretion system needle tip complex.
Q37665331Timing is everything: the regulation of type III secretion
Q37368717Translational regulation of Yersinia enterocolitica mRNA encoding a type III secretion substrate
Q34048607Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranes
Q36744798Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex
Q34270387Type III secretion in Yersinia: injectisome or not?
Q36969851Type III secretion systems and disease
Q38586932Type III secretion systems: the bacterial flagellum and the injectisome
Q39218275Type III secretion translocon assemblies that attenuate Yersinia virulence.
Q89950008Type three secretion system in Salmonella Typhimurium: the key to infection
Q42183752Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneri
Q27008415V-antigen homologs in pathogenic gram-negative bacteria
Q36950063Vaccination of mice with a Yop translocon complex elicits antibodies that are protective against infection with F1- Yersinia pestis
Q60934153Visualization of translocons in Yersinia type III protein secretion machines during host cell infection
Q33964205Vp1659 is a Vibrio parahaemolyticus type III secretion system 1 protein that contributes to translocation of effector proteins needed to induce cytolysis, autophagy, and disruption of actin structure in HeLa cells
Q36638746What's the point of the type III secretion system needle?
Q21559505Yersinia controls type III effector delivery into host cells by modulating Rho activity
Q41380323Yersinia enterocolitica type III secretion injectisomes form regularly spaced clusters, which incorporate new machines upon activation
Q41441370Yersinia enterocolitica type III secretion of YopR requires a structure in its mRNA
Q37191268Yersinia pestis IS1541 transposition provides for escape from plague immunity
Q36594087Yersinia pestis caf1 variants and the limits of plague vaccine protection
Q41437577Yersinia pestis can bypass protective antibodies to LcrV and activation with gamma interferon to survive and induce apoptosis in murine macrophages
Q26747057Yersinia virulence factors - a sophisticated arsenal for combating host defences
Q41433693YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis
Q41405474YopK controls both rate and fidelity of Yop translocation
Q33731425YopR impacts type III needle polymerization in Yersinia species
Q39758533YscP and YscU switch the substrate specificity of the Yersinia type III secretion system by regulating export of the inner rod protein YscI.
Q36513832YscU cleavage and the assembly of Yersinia type III secretion machine complexes
Q30479614YscU recognizes translocators as export substrates of the Yersinia injectisome

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