Structure and biophysics of type III secretion in bacteria

scientific article published on 05 April 2013

Structure and biophysics of type III secretion in bacteria is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/BI400160A
P932PMC publication ID3711828
P698PubMed publication ID23521714

P2093author name stringRoberto N De Guzman
Sukanya Chaudhury
Srirupa Chatterjee
Kawaljit Kaur
Andrew C McShan
P2860cites workTopology and organization of the Salmonella typhimurium type III secretion needle complex componentsQ21131560
Structural insights into the assembly of the type III secretion needle complex.Q24547949
LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestisQ24548891
Atomic model of the type III secretion system needleQ24604172
Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughoutQ24644829
The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar systemQ24646298
Molecular model of a type III secretion system needle: Implications for host-cell sensingQ24670035
Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interfaceQ24797087
The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plagueQ27643133
Structural analysis of a prototypical ATPase from the type III secretion systemQ27643589
Structure of the heterotrimeric complex that regulates type III secretion needle formationQ27644654
Differences in the Electrostatic Surfaces of the Type III Secretion Needle Proteins PrgI, BsaL, and MxiHQ27646583
Structure of the Yersinia enterocolitica type III secretion translocator chaperone SycDQ27649199
Structural Characterization of the Yersinia pestis Type III Secretion System Needle Protein YscF in Complex with Its Heterodimeric Chaperone YscE/YscGQ27649875
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaSQ27650496
Crystal structure of Spa40, the specificity switch for theShigella flexneritype III secretion systemQ27650631
Structural characterization of the type-III pilot-secretin complex from Shigella flexneriQ27652595
Structure of the type III secretion recognition protein YscU from Yersinia enterocoliticaQ27652717
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion systemQ27655277
IpaB-IpgC interaction defines binding motif for type III secretion translocatorQ27655665
Structure of the cytoplasmic domain of FlhA and implication for flagellar type III protein exportQ27660101
Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvAQ27660301
Structural Basis of Chaperone Recognition of Type III Secretion System Minor Translocator ProteinsQ27660501
Protein refolding is required for assembly of the type three secretion needleQ27662205
Combination of Two Separate Binding Domains Defines Stoichiometry between Type III Secretion System Chaperone IpgC and Translocator Protein IpaBQ27664968
The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholateQ27665429
Three-dimensional model of Salmonella's needle complex at subnanometer resolutionQ27666889
Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction.Q42128361
Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneriQ42183752
IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cellsQ42206130
Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerizationQ42440794
Identification of the MxiH needle protein residues responsible for anchoring invasion plasmid antigen D to the type III secretion needle tip.Q42518529
Direct nucleation and bundling of actin by the SipC protein of invasive SalmonellaQ42680869
Bile salts stimulate recruitment of IpaB to the Shigella flexneri surface, where it colocalizes with IpaD at the tip of the type III secretion needleQ42799643
Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cellsQ42816094
Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri.Q44213448
Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bileQ47600033
The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topologyQ48555964
13C spin dilution for simplified and complete solid-state NMR resonance assignment of insoluble biological assemblies.Q50042875
Analysis of functional domains present in the N-terminus of the SipB proteinQ50068971
High resolution structure of BipD: an invasion protein associated with the type III secretion system of Burkholderia pseudomalleiQ50077363
Assembly of the inner rod determines needle length in the type III secretion injectisomeQ50080247
The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cellQ50134497
Synergistic Pore Formation by Type III Toxin Translocators ofPseudomonas aeruginosa†Q57365041
Structural and functional studies of the enteropathogenicEscherichia colitype III needle complex protein EscJQ60287286
Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranesQ72991854
Identification of functional regions within invasion plasmid antigen C (IpaC) of Shigella flexneriQ73312849
The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneriQ73510444
Spectroscopic and calorimetric analyses of invasion plasmid antigen D (IpaD) from Shigella flexneri reveal the presence of two structural domainsQ79982088
The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatusQ81355843
Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiGQ27670706
Crystal Structure of PrgI-SipD: Insight into a Secretion Competent State of the Type Three Secretion System Needle Tip and its Interaction with Host LigandsQ27671650
Architecture of the major component of the type III secretion system export apparatusQ27675415
The Structures of Coiled-Coil Domains from Type III Secretion System Translocators Reveal Homology to Pore-Forming ToxinsQ27677178
Structure of a type III secretion needle at 7-A resolution provides insights into its assembly and signaling mechanismsQ27677828
Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure.Q27678066
Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopDQ27681220
Structure and composition of the Shigella flexneri "needle complex", a part of its type III secretonQ28199735
Helical structure of the needle of the type III secretion system of Shigella flexneriQ28207810
Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomalleiQ28235978
Chaperone release and unfolding of substrates in type III secretionQ28275782
PscF is a major component of the Pseudomonas aeruginosa type III secretion needleQ28493056
The type III secretion injectisomeQ29617944
Characterization of the interaction between the Salmonella type III secretion system tip protein SipD and the needle protein PrgI by paramagnetic relaxation enhancementQ30428389
The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cellsQ30438369
Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cellsQ30488707
Deciphering the assembly of the Yersinia type III secretion injectisomeQ30494891
Virulence role of V antigen of Yersinia pestis at the bacterial surfaceQ30778457
Structural characterization of the molecular platform for type III secretion system assembly.Q33216321
The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cellsQ33552436
Role of predicted transmembrane domains for type III translocation, pore formation, and signaling by the Yersinia pseudotuberculosis YopB proteinQ33769194
Complex function for SicA, a Salmonella enterica serovar typhimurium type III secretion-associated chaperoneQ33789355
The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranesQ33878820
Structure and biochemical analysis of a secretin pilot proteinQ33937224
Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structureQ33944789
Salmonella enterica serovar typhimurium invasion is repressed in the presence of bileQ34005208
Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranesQ34048607
Organization and coordinated assembly of the type III secretion export apparatusQ34200197
Identification of novel protein-protein interactions of Yersinia pestis type III secretion system by yeast two hybrid systemQ34562642
Supramolecular structure of the Salmonella typhimurium type III protein secretion systemQ34746894
Yersinia type III secretion: send in the effectorsQ34774578
Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV.Q35071514
Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18Q35165335
Structure and electrophysiological properties of the YscC secretin from the type III secretion system of Yersinia enterocoliticaQ35279783
Increased protein secretion and adherence to HeLa cells by Shigella spp. following growth in the presence of bile saltsQ35439004
IpaB, a Shigella flexneri invasin, colocalizes with interleukin-1 beta-converting enzyme in the cytoplasm of macrophagesQ35567691
Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cellsQ35589961
Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.Q35846739
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cellsQ36122200
The Salmonella type III secretion system inner rod protein PrgJ is partially folded.Q36127196
A translocator-specific export signal establishes the translocator-effector secretion hierarchy that is important for type III secretion system functionQ36472851
What's the point of the type III secretion system needle?Q36638746
Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.Q36984033
Piecing together the type III injectisome of bacterial pathogensQ37079418
Simultaneous prediction of protein folding and docking at high resolutionQ37404702
Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion systemQ37434696
Impact of the N-terminal secretor domain on YopD translocator function in Yersinia pseudotuberculosis type III secretionQ39464419
Deoxycholate interacts with IpaD of Shigella flexneri in inducing the recruitment of IpaB to the type III secretion apparatus needle tip.Q39627554
YscP and YscU switch the substrate specificity of the Yersinia type III secretion system by regulating export of the inner rod protein YscI.Q39758533
Soluble invasion plasmid antigen C (IpaC) from Shigella flexneri elicits epithelial cell responses related to pathogen invasionQ39826253
The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding.Q39896038
The C terminus of SipC binds and bundles F-actin to promote Salmonella invasionQ40186424
IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes.Q40454544
Characterization of Salmonella pathogenicity island 1 type III secretion-dependent hemolytic activity in Salmonella enterica serovar TyphimuriumQ40525336
The V antigen of Pseudomonas aeruginosa is required for assembly of the functional PopB/PopD translocation pore in host cell membranesQ41195095
The assembly of the export apparatus (YscR,S,T,U,V) of the Yersinia type III secretion apparatus occurs independently of other structural components and involves the formation of an YscV oligomer.Q41425944
Function and molecular architecture of the Yersinia injectisome tip complexQ41447558
Structure-function analysis of the C-terminal domain of LcrV from Yersinia pestis.Q41447992
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needlesQ41456399
Dissection of homologous translocon operons reveals a distinct role for YopD in type III secretion by Yersinia pseudotuberculosisQ41465782
Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains.Q41471377
Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: requirement for translocators YopB and YopD, but not LcrG.Q41481875
Role of SycD, the chaperone of the Yersinia Yop translocators YopB and YopD.Q41483801
Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosisQ41484833
Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneriQ41497452
IpaD localizes to the tip of the type III secretion system needle of Shigella flexneriQ41856079
A sorting platform determines the order of protein secretion in bacterial type III systemsQ41876550
Binding affects the tertiary and quaternary structures of the Shigella translocator protein IpaB and its chaperone IpgC.Q41893547
Conformational changes in IpaD from Shigella flexneri upon binding bile salts provide insight into the second step of type III secretion.Q41894482
Domains of the Shigella flexneri Type III Secretion System IpaB Protein Involved in Secretion RegulationQ42048473
NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile saltsQ42126458
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
bacteriaQ10876
P304page(s)2508-2517
P577publication date2013-04-05
P1433published inBiochemistryQ764876
P1476titleStructure and biophysics of type III secretion in bacteria
P478volume52

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cites work (P2860)
Q34447679Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens.
Q38183945Assembly of the bacterial type III secretion machinery.
Q34160717Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host
Q27028058Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells
Q28067720Biological significance and topological basis of aquaporin-partnering protein-protein interactions
Q39749016Burkholderia pseudomallei type III secreted protein BipC: role in actin modulation and translocation activities required for the bacterial intracellular lifecycle.
Q37231188Characterization of the Binding of Hydroxyindole, Indoleacetic acid, and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB.
Q37032486Characterization of the Shigella and Salmonella Type III Secretion System Tip-Translocon Protein-Protein Interaction by Paramagnetic Relaxation Enhancement
Q41050348Comparative Genomics Identifies a Novel Conserved Protein, HpaT, in Proteobacterial Type III Secretion Systems that Do Not Possess the Putative Translocon Protein HrpF.
Q35058968Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor
Q35494390Computational and experimental analysis of the secretome of Methylococcus capsulatus (Bath)
Q47405825Deoxycholate-Enhanced Shigella Virulence Is Regulated by a Rare π-Helix in the Type Three Secretion System Tip Protein IpaD.
Q92915177Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence
Q37167670Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides
Q39685418ExsB is required for correct assembly of the Pseudomonas aeruginosa type III secretion apparatus in the bacterial membrane and full virulence in vivo
Q38307864Getting across the cell membrane: an overview for small molecules, peptides, and proteins
Q58765188Hpa1 is a type III translocator in Xanthomonas oryzae pv. oryzae
Q92515642Identification and characterization of putative Aeromonas spp. T3SS effectors
Q40298917In Situ Molecular Architecture of the Salmonella Type III Secretion Machine
Q38282188Key steps in type III secretion system (T3SS) towards translocon assembly with potential sensor at plant plasma membrane.
Q38837738Mechanisms of Salmonella Typhi Host Restriction
Q28661556Microcompartments and protein machines in prokaryotes
Q90091019Multiple proteins arising from a single gene: The role of the Spa33 variants in Shigella T3SS regulation
Q54245973MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47.
Q38777104NMR identification of the binding surfaces involved in the Salmonella and Shigella Type III secretion tip-translocon protein-protein interactions
Q41838952NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system
Q37264192Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines
Q92700449Plant Aquaporins in Infection by and Immunity Against Pathogens - A Critical Review
Q97538439Possible drugs for the treatment of bacterial infections in the future: anti-virulence drugs
Q41641450Pseudomonas aeruginosa Genome Evolution in Patients and under the Hospital Environment
Q90013430Real-time monitoring of translocation of selected type-III effectors from Xanthomonas oryzae pv. oryzae into rice cells
Q92676267Rice aquaporin PIP1;3 and harpin Hpa1 of bacterial blight pathogen cooperate in a type III effector translocation
Q28354066Role of T3SS-1 SipD Protein in Protecting Mice against Non-typhoidal Salmonella Typhimurium
Q90398268Salmonella Virulence and Immune Escape
Q51730423Secretome analysis of Anabaena sp. PCC 7120 and the involvement of the TolC-homologue HgdD in protein secretion.
Q26781403Small-Molecule Inhibitors of the Type III Secretion System
Q40413291Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri
Q40442116Structural analysis of SepL, an enteropathogenic Escherichia coli type III secretion-system gatekeeper protein
Q40492562Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.
Q34964228Structural basis of α-catenin recognition by EspB from enterohaemorrhagic E. coli based on hybrid strategy using low-resolution structural and protein dissection
Q35023691Targeting virulence not viability in the search for future antibacterials.
Q40640251The LcrG Tip Chaperone Protein of the Yersinia pestis Type III Secretion System Is Partially Folded.
Q35866021The RNA Helicase DeaD Stimulates ExsA Translation To Promote Expression of the Pseudomonas aeruginosa Type III Secretion System.
Q42328253The bacterial type III secretion system as a target for developing new antibiotics
Q37495040The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system
Q47341878The inner-rod component of Shigella flexneri type 3 secretion system, MxiI, is involved in the transmission of the secretion activation signal by its interaction with MxiC.
Q35149904The pathogenesis, detection, and prevention of Vibrio parahaemolyticus
Q98465479Three Proteins (Hpa2, HrpF and XopN) Are Concomitant Type III Translocators in Bacterial Blight Pathogen of Rice
Q38214489Tracking bacterial pathogens with genetically-encoded reporters.
Q38586932Type III secretion systems: the bacterial flagellum and the injectisome
Q48114171Visualization and characterization of individual type III protein secretion machines in live bacteria

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