Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.

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Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M116.755256
P932PMC publication ID5207059
P698PubMed publication ID27770024

P50authorSean JohnsonQ43162694
Nicholas E DickensonQ50986177
Yalemi MoralesQ57774616
P2093author name stringJamie L Burgess
R Alan Burgess
Jenna M Bouvang
P2860cites workDistantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding foldQ24556499
Modern analytical ultracentrifugation in protein science: a tutorial reviewQ24645050
MolProbity: all-atom structure validation for macromolecular crystallographyQ24649111
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Förster resonance energy transfer (FRET) as a tool for dissecting the molecular mechanisms for maturation of the Shigella type III secretion needle tip complexQ26995596
Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cellsQ27028058
Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPaseQ27322401
Structural similarity between the flagellar type III ATPase FliI and F1-ATPase subunitsQ27641045
Shigella manipulates host immune responses by delivering effector proteins with specific rolesQ38497238
Type III secretion systems: the bacterial flagellum and the injectisomeQ38586932
Type III Secretion: Building and Operating a Remarkable Nanomachine.Q38621246
Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneriQ39520014
Deoxycholate interacts with IpaD of Shigella flexneri in inducing the recruitment of IpaB to the type III secretion apparatus needle tip.Q39627554
Intracellular type III secretion by cytoplasmic Shigella flexneri promotes caspase-1-dependent macrophage cell deathQ40085811
Experimental Shigella infections: characteristics of a fatal infection produced in guinea pigs.Q40314454
Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneriQ40413291
The Architecture of the Cytoplasmic Region of Type III Secretion SystemsQ40522214
MxiK and MxiN interact with the Spa47 ATPase and are required for transit of the needle components MxiH and MxiI, but not of Ipa proteins, through the type III secretion apparatus of Shigella flexneriQ41466218
Double hexameric ring assembly of the type III protein translocase ATPase HrcN.Q41625952
Oligomerization and activation of the FliI ATPase central to bacterial flagellum assembly.Q41817833
Principal role of the arginine finger in rotary catalysis of F1-ATPase.Q41818905
IpaD localizes to the tip of the type III secretion system needle of Shigella flexneriQ41856079
Conformational changes in IpaD from Shigella flexneri upon binding bile salts provide insight into the second step of type III secretion.Q41894482
Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction.Q42128361
Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneriQ42183752
Three-dimensional electron microscopy reconstruction and cysteine-mediated crosslinking provide a model of the type III secretion system needle tip complex.Q42566246
Newly emerged multiple-antibiotic-resistant Shigella dysenteriae type 1 strains in and around Kolkata, India, are clonalQ42591588
The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneriQ42638971
ATP-induced FliI hexamerization facilitates bacterial flagellar protein exportQ43295990
Distinct roles of the FliI ATPase and proton motive force in bacterial flagellar protein exportQ46793605
Secretion of type III effectors into host cells in real timeQ46813523
Oligomerization of the bacterial flagellar ATPase FliI is controlled by its extreme N-terminal region.Q50079660
Molecular dissection of Salmonella FliH, a regulator of the ATPase FliI and the type III flagellar protein export pathway.Q50108067
FliH, a soluble component of the type III flagellar export apparatus of Salmonella, forms a complex with FliI and inhibits its ATPase activity.Q50119364
Enzymatic characterization of FliI. An ATPase involved in flagellar assembly in Salmonella typhimurium.Q50136458
Enzymatic characterization of the enteropathogenic Escherichia coli type III secretion ATPase EscN.Q54432108
Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structuresQ64360979
The catalytic transition state in ATP synthaseQ80341752
The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatusQ81355843
A Yersinia pestis YscN ATPase mutant functions as a live attenuated vaccine against bubonic plague in miceQ84002354
Structural analysis of a prototypical ATPase from the type III secretion systemQ27643589
Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondriaQ27730864
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensionsQ27860532
Towards automated crystallographic structure refinement with phenix.refineQ27860678
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal OmegaQ27860809
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
The PSIPRED protein structure prediction serverQ27860953
Features and development of CootQ27861079
Structure and composition of the Shigella flexneri "needle complex", a part of its type III secretonQ28199735
AAA+ superfamily ATPases: common structure--diverse functionQ28208908
Chaperone release and unfolding of substrates in type III secretionQ28275782
XpsE oligomerization triggered by ATP binding, not hydrolysis, leads to its association with XpsLQ28488497
Functional characterization of the type III secretion ATPase SsaN encoded by Salmonella pathogenicity island 2Q28490001
AAA+ proteins: have engine, will workQ29617410
The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranesQ33878820
Genetic analysis of assembly of the Salmonella enterica serovar Typhimurium type III secretion-associated needle complex.Q33995538
Genetic analysis of the Salmonella enterica type III secretion-associated ATPase InvC defines discrete functional domainsQ34001510
Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargoQ34141168
Bacterial invasion: the paradigms of enteroinvasive pathogensQ34312229
Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control studyQ34345075
Catalysis and rotation of F1 motor: cleavage of ATP at the catalytic site occurs in 1 ms before 40 degree substep rotationQ34384279
Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulator, YscL.Q34696832
Visualization of the type III secretion sorting platform of Shigella flexneriQ35037858
Molecular and functional characterization of the Salmonella typhimurium invasion genes invB and invC: homology of InvC to the F0F1 ATPase family of proteinsQ35967361
YscN, the putative energizer of the Yersinia Yop secretion machineryQ36105907
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cellsQ36122200
Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.Q36422508
Quantitation of HeLa cell monolayer invasion by Shigella and Salmonella speciesQ36500393
FliH and FliI ensure efficient energy coupling of flagellar type III protein export in Salmonella.Q36999741
Structure and biophysics of type III secretion in bacteriaQ37014297
Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysisQ37056339
The inside story of Shigella invasion of intestinal epithelial cellsQ37201463
Characterization of the putative type III secretion ATPase CdsN (Cpn0707) of Chlamydophila pneumoniaeQ37856790
The ATP synthase: the understood, the uncertain and the unknown.Q38077205
P4510describes a project that usesImageQuantQ112270642
P433issue50
P407language of work or nameEnglishQ1860
P304page(s)25837-25852
P577publication date2016-10-21
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation
P478volume291

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cites work (P2860)
Q92915177Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence
Q44059155Identification of chlamydial T3SS inhibitors through virtual screening against T3SS ATPase
Q59125136Kinetic Characterization of the Shigella Type Three Secretion System ATPase Spa47 Using α-32P ATP
Q54245973MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47.
Q90170341On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome
Q93262668Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors
Q90259043Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase From Shigella flexneri
Q92498892Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC