Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells

scientific article published on May 2005

Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2958.2005.04568.X
P698PubMed publication ID15819617
P5875ResearchGate publication ID7916414

P50authorRichard D HaywardQ42756784
Vassilis KoronakisQ42756793
P2093author name stringRobert J Cain
Emma J McGhie
Matthew J Garner
Neil Phillips
P2860cites workCD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cellsQ24290851
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphologyQ24534908
Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptideQ24546891
Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 diseaseQ24554202
Crystal structure determination of cholesterol oxidase from Streptomyces and structural characterization of key active site mutantsQ27617816
Structure and lipid transport mechanism of a StAR-related domainQ27622485
Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretionQ27635933
The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active siteQ27639545
Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activationQ27749097
Functional rafts in cell membranesQ27860768
Discrete backbone disorder in the nuclear magnetic resonance structure of apo intestinal fatty acid-binding protein: implications for the mechanism of ligand entryQ28909784
Port of entry--the type III secretion transloconQ30320840
Type III secretion machines: bacterial devices for protein delivery into host cellsQ33639326
Thiol-activated cytolysins: structure, function and role in pathogenesisQ33808537
Assembly and function of type III secretory systemsQ34052773
Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interactionQ34091098
How cells handle cholesterol.Q34094514
Unravelling the significance of cellular fatty acid-binding proteinsQ34251142
Bacterial invasion: the paradigms of enteroinvasive pathogensQ34312229
Rafts can trigger contact-mediated secretion of bacterial effectors via a lipid-based mechanismQ34347987
The Yersinia Ysc-Yop 'type III' weaponryQ34931776
Microbial pathogenesis and cytoskeletal function.Q35109715
Adhesion of enteropathogenic Escherichia coli to host cells.Q35142691
Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferationQ35550354
Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cellsQ35589961
Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysinQ36310741
Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanismQ36650801
Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actinQ39644435
Oligomerization of type III secretion proteins PopB and PopD precedes pore formation in PseudomonasQ39927824
The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin.Q40281548
Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteriaQ40829555
LcrV is a channel size-determining component of the Yop effector translocon of YersiniaQ41477086
Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cellsQ41491681
Direct nucleation and bundling of actin by the SipC protein of invasive SalmonellaQ42680869
The Salmonella pathogenicity island 1 secretion system directs cellular cholesterol redistribution during mammalian cell entry and intracellular traffickingQ42817457
The target cell plasma membrane is a critical interface for Salmonella cell entry effector-host interplayQ42823992
Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formationQ42827785
The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55.Q44029864
Caveolin scaffolding region and cholesterol-rich domains in membranesQ45168181
The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topologyQ48555964
Topology of the Salmonella invasion protein SipB in a model bilayerQ48558570
Fluorescence of delta 5,7,9(11),22-ergostatetraen-3 beta-ol in micelles, sterol carrier protein complexes, and plasma membranesQ49248552
A Salmonella SipB-derived polypeptide blocks the 'trigger' mechanism of bacterial entry into eukaryotic cellsQ50107213
The Salmonella type III secretion translocon protein SspC is inserted into the epithelial cell plasma membrane upon infectionQ50119640
Membrane fusion activity of purified SipB, a Salmonella surface protein essential for mammalian cell invasionQ50119648
The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cellQ50134497
Elicitins, Proteinaceous Elicitors of Plant Defense, Are a New Class of Sterol Carrier ProteinsQ57643061
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)590-603
P577publication date2005-05-01
P1433published inMolecular MicrobiologyQ6895967
P1476titleCholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells
P478volume56

Reverse relations

cites work (P2860)
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