A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact

scientific article published on 8 March 2013

A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact is …
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scholarly articleQ13442814

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P356DOI10.1128/JB.02011-12
P932PMC publication ID3650545
P698PubMed publication ID23475976

P2093author name stringJoan Mecsas
Alison J Davis
Julia L Murphy
Dana E Harmon
P2860cites workThe Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD.Q24520677
Molecular model of a type III secretion system needle: Implications for host-cell sensingQ24670035
Differential effects of deletions in lcrV on secretion of V antigen, regulation of the low-Ca2+ response, and virulence of Yersinia pestisQ24673488
LcrV, a substrate for Yersinia enterocolitica type III secretion, is required for toxin targeting into the cytosol of HeLa cellsQ28142834
The virulence plasmid of Yersinia, an antihost genomeQ28290675
The type III secretion injectisomeQ29617944
Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosisQ33585993
Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosisQ33678428
The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infectionQ34005540
The type III secretion system tip complex and translocon.Q34011259
Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranesQ34048607
Plague and other human infections caused by Yersinia speciesQ34399022
Translocation of surface-localized effectors in type III secretionQ34533819
Current trends in plague research: from genomics to virulenceQ35040132
Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissuesQ35165118
Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cellsQ35290671
Plague bacteria target immune cells during infectionQ35535438
Yersinia pestis LcrV forms a stable complex with LcrG and may have a secretion-related regulatory role in the low-Ca2+ responseQ35620091
Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP.Q35688976
Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.Q35846739
The Ability To Replicate in Macrophages Is Conserved between Yersinia pestis and Yersinia pseudotuberculosisQ36044907
The Yersinia pestis V antigen is a regulatory protein necessary for Ca2(+)-dependent growth and maximal expression of low-Ca2+ response virulence genesQ36144953
LcrV mutants that abolish Yersinia type III injectisome functionQ36581211
Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.Q36984033
Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vectorQ36989608
A low-Ca2+ response operon encodes the V antigen of Yersinia pestis.Q37013218
Virulence genes regulated at the transcriptional level by Ca2+ in Yersinia pestis include structural genes for outer membrane proteinsQ37056284
Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model.Q37283839
The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding.Q39896038
Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cellsQ40214494
Oligomerization of PcrV and LcrV, protective antigens of Pseudomonas aeruginosa and Yersinia pestis.Q40451950
Genetic analysis of the formation of the Ysc-Yop translocation pore in macrophages by Yersinia enterocolitica: role of LcrV, YscF and YopN.Q40622724
The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activityQ41077827
In silico comparison of Yersinia pestis and Yersinia pseudotuberculosis transcriptomes reveals a higher expression level of crucial virulence determinants in the plague bacillusQ41431745
YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosisQ41433693
A dominant-negative needle mutant blocks type III secretion of early but not late substrates in YersiniaQ41435019
Function and molecular architecture of the Yersinia injectisome tip complexQ41447558
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needlesQ41456399
The Yersinia pestis type III secretion needle plays a role in the regulation of Yop secretionQ41457055
Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranesQ41458033
LcrV is a channel size-determining component of the Yop effector translocon of YersiniaQ41477086
The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulenceQ41478657
Yersinia enterocolitica type III secretion-translocation system: channel formation by secreted YopsQ41481194
The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocationQ41482701
Translocation of the Yersinia YopE and YopH virulence proteins into target cells is mediated by YopB and YopD.Q41495861
Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coliQ48314806
The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.Q53575352
The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatusQ81355843
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)2244-2254
P577publication date2013-03-08
P1433published inJournal of BacteriologyQ478419
P1476titleA mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact
P478volume195