Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression

scientific article published on 24 February 2016

Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YEXCR.2016.02.015
P932PMC publication ID4818121
P698PubMed publication ID26921506

P2093author name stringDennis R Warner
M Michele Pisano
Robert M Greene
Irina A Smolenkova
Scott C Smith
P2860cites workSelective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells.Q39148603
Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genesQ39253940
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate developmentQ41490403
Critical role of histone acetylation by p300 in human placental 11β-HSD2 expression.Q42439079
Functional analysis of CBP/p300 in embryonic orofacial mesenchymal cellsQ42497746
Down-regulation of Wnt10a by RNA interference inhibits proliferation and promotes apoptosis in mouse embryonic palatal mesenchymal cells through Wnt/β-catenin signaling pathwayQ46808995
Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiologyQ48436070
Negative interplay of retinoic acid and TGF-β signaling mediated by TG-interacting factor to modulate mouse embryonic palate mesenchymal-cell proliferation.Q53676036
Cross-talk between the TGFbeta and Wnt signaling pathways in murine embryonic maxillary mesenchymal cellsQ81849087
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Protein lysine acetylation by p300/CBPQ27021749
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defectsQ28512647
Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissueQ28591010
Transforming growth factor-beta modulation of glycosaminoglycan production by mesenchymal cells of the developing murine secondary palateQ33559407
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitorQ33599508
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause diseaseQ33942130
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cellsQ34580082
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBPQ34977966
MicroRNA expression profiling of the developing murine upper lip.Q35231639
Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitroQ35632155
Altering cancer transcriptomes using epigenomic inhibitorsQ35863203
Genetics of syndromic and nonsyndromic cleft lip and palateQ37940802
Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620.Q38957982
C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe.Q39002969
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)32-38
P577publication date2016-02-24
P1433published inExperimental Cell ResearchQ1524289
P1476titleInhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression
P478volume342

Reverse relations

cites work (P2860)
Q33751094Promoter methylation status of the tumor suppressor genes p16 and cadherin 1 in cervical intraepithelial neoplasia
Q64236020Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models