Altering cancer transcriptomes using epigenomic inhibitors

scientific article published on 24 February 2015

Altering cancer transcriptomes using epigenomic inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1032742151
P356DOI10.1186/1756-8935-8-9
P932PMC publication ID4506402
P698PubMed publication ID26191083
P5875ResearchGate publication ID278729473

P50authorPeggy FarnhamQ30503476
P2093author name stringSeth Frietze
Malaina Gaddis
Diana Gerrard
P2860cites workWnt/beta-catenin signaling in development and diseaseQ27860784
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Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitorQ33599508
The coactivators p300 and CBP have different functions during the differentiation of F9 cellsQ33727375
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Q33858490
CBP and p300: HATs for different occasionsQ33980693
Chromatin proteins and modifications as drug targetsQ34038652
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Wnt/beta-catenin signaling pathway as a novel cancer drug targetQ35971885
Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosisQ36005381
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Wnt signaling inside the nucleusQ37051434
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and functionQ37290564
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Histone acetyl transferases as emerging drug targets.Q37540911
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SREBP: a novel therapeutic targetQ38069003
Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic CancerQ38945152
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Canonical wnt signaling is required for pancreatic carcinogenesisQ39140268
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Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistanceQ39303333
p8 expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesisQ39587471
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer.Q39660739
p8 is a new target of gemcitabine in pancreatic cancer cellsQ40333276
Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expressionQ40443907
NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stressQ46437952
Targeting the epigenome for treatment of cancer.Q53201323
Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway.Q55070717
Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interactionQ83188973
Further case of Rubinstein-Taybi syndrome due to a deletion in EP300Q83624716
P4510describes a project that usesedgeRQ113334690
P304page(s)9
P577publication date2015-02-24
P1433published inEpigenetics & ChromatinQ15765513
P1476titleAltering cancer transcriptomes using epigenomic inhibitors
P478volume8

Reverse relations

cites work (P2860)
Q64080156Digital expression explorer 2: a repository of uniformly processed RNA sequencing data
Q91792286Disruption of Broad Epigenetic Domains in PDAC Cells by HAT Inhibitors
Q36914561Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells
Q49427525Exon 3 mutations of CTNNB1 drive tumorigenesis: a review
Q92876708Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals
Q41718159Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer.
Q91776475Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification
Q38363468Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation
Q36757654Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression
Q47124134Integrative analysis to identify oncogenic gene expression changes associated with copy number variations of enhancer in ovarian cancer
Q90643583Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
Q48223411Pharmacological targeting of BET proteins attenuates radiation-induced lung fibrosis.
Q49237718Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids
Q47129410Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth
Q52715499Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes?
Q30383560The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.
Q90476746Three-dimensional analysis reveals altered chromatin interaction by enhancer inhibitors harbors TCF7L2-regulated cancer gene signature

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