Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals

scientific article published on 19 June 2019

Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1008181
P932PMC publication ID6602261
P698PubMed publication ID31216276

P50authorMing-Lung YuQ57002538
Tomer MeirsonQ41045081
Gur YaariQ41050662
Assam El-ostaQ43160132
P2093author name stringRaymond T Chung
Meital Gal-Tanamy
Chia-Yen Dai
Antony Kaspi
Izhak Haviv
Chung-Feng Huang
Salomon M Stemmer
Ateret Davidovich
Jacinta Alison Holmes
Anat Lavi-Itzkovitz
Shira Perez
Assy Nimer
Tom Domovitz
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Compensatory Mutations in E1, p7, NS2, and NS3 Enhance Yields of Cell Culture-Infectious Intergenotypic Chimeric Hepatitis C VirusQ27478033
CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human HepatocytesQ27486789
Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus ParticlesQ27489056
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Knowledge-based analysis of proteomics dataQ30578329
Chromatin at the intersection of viral infection and DNA damageQ33729186
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Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinomaQ33863710
Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycleQ33893794
Viral hit and run-oncogenesis: Genetic and epigenetic scenariosQ34135741
Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?Q34358742
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An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.Q34670759
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cellsQ35451716
Cell-of-origin chromatin organization shapes the mutational landscape of cancerQ35510462
Inhibition of protease-inhibitor-resistant hepatitis C virus replicons and infectious virus by intracellular intrabodies.Q35565927
Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy.Q52332749
"Newly diagnosed Hepatocellular Carcinoma in patients with advanced hepatitis C treated with DAAs: a prospective population study".Q52649962
Molecular Pathways: The Complexity of the Epigenome in Cancer and Recent Clinical AdvancesQ58862228
Is hepatitis C virus carcinogenic?Q35576656
Altering cancer transcriptomes using epigenomic inhibitorsQ35863203
Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblastsQ36214096
How do persistent infections with hepatitis C virus cause liver cancer?Q36236839
Hepatitis C-related hepatocellular carcinoma in the era of new generation antiviralsQ36306768
Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytesQ36414367
Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repairQ36565849
Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosisQ36788468
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemiaQ36916418
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapyQ37609988
Exploring the genomes of cancer cells: progress and promiseQ37857590
Epigenetic memory in the context of nuclear reprogramming and cancerQ38098977
Mechanisms underlying mutational signatures in human cancersQ38225013
Ombitasvir/paritaprevir/ritonavir and dasabuvir tablets for hepatitis C virus genotype 1 infectionQ38355057
Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway InhibitionQ38726399
Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling studyQ38839762
A cell culture system for distinguishing hepatitis C viruses with and without liver cancer-related mutations in the viral core gene.Q38848401
Hepatitis virus infection affects DNA methylation in mice with humanized livers.Q39067748
Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers.Q39138235
Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasionQ39246449
Hepatitis C virus infection causes cell cycle arrest at the level of initiation of mitosisQ39523228
Signalome-wide assessment of host cell response to hepatitis C virusQ40211267
Persisting risk of hepatocellular carcinoma after hepatitis C virus cure monitored by a liver transcriptome signature.Q40252283
A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targetsQ40512450
Direct-Acting Antiviral-Induced Hepatitis C Virus Clearance Does Not Completely Restore the Altered Cytokine and Chemokine Milieu in Patients With Chronic Hepatitis C.Q40523304
Immunological Analysis During Interferon-Free Therapy for Chronic Hepatitis C Virus Infection Reveals Modulation of the Natural Killer Cell CompartmentQ41082823
An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT.Q41665498
Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitroQ42143878
Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphataseQ42454464
Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.Q42994110
Levels of Cytokines in Serum Associate With Development of Hepatocellular Carcinoma in Patients With HCV Infection Treated With Direct-acting Antivirals.Q47590714
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesedgeRQ113334690
P433issue6
P921main subjectHepatitis C virusQ708693
P304page(s)e1008181
P577publication date2019-06-19
P1433published inPLOS GeneticsQ1893441
P1476titleHepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals
P478volume15

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cites work (P2860)
Q92441611Gene Expression Profiling of Different Huh7 Variants Reveals Novel Hepatitis C Virus Host Factors
Q106624325Genome‐wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID‐19
Q90228670Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-miR-122 Feedback Loop in Liver Fibrosis and Cancer Progression
Q94453487Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment
Q90387894Synergistic lethal mutagenesis of hepatitis C virus
Q90689008Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma
Q89860205The Effect of Viral Clearance Achieved by Direct-Acting Antiviral Agents on Hepatitis C Virus Positive Patients with Type 2 Diabetes Mellitus: A Word of Caution after the Initial Enthusiasm
Q90434504Unmet needs of chronic hepatitis C in the era of direct-acting antiviral therapy

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