Wnt signaling inside the nucleus

scientific article published on 02 January 2008

Wnt signaling inside the nucleus is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1349-7006.2007.00716.X
P698PubMed publication ID18177486
P5875ResearchGate publication ID5673678

P50authorTesshi YamadaQ88326275
Setsuo HirohashiQ116761102
P2093author name stringMiki Shitashige
P2860cites workCellular roles of dna topoisomerases: a molecular perspectiveQ22121990
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signalingQ24295533
The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathwayQ24296279
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleusQ24297804
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complexQ24299664
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathwayQ24300418
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcomaQ24304506
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer developmentQ24307491
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcomaQ24309359
Identification of c-MYC as a target of the APC pathwayQ24310637
Physiological and functional interactions between Tcf4 and Daxx in colon cancer cellsQ24311467
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsQ24314491
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/ArmadilloQ24319343
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaQ24336272
Cancer genetics: colorectal cancer as a model.Q36441076
Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitroQ36819376
PolyADP-ribosylation and cancerQ36889328
Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesisQ38297807
Etoposide: A Semisynthetic Epipodophyllotoxin Chemistry, Pharmacology, Pharmacokinetics, Adverse Effects and Use as an Antineoplastic AgentQ40141842
Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing.Q40154769
RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1.Q40346466
Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.Q40361099
Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expressionQ40443907
Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinomaQ40651937
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumorsQ40949632
beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancerQ42794991
PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoterQ45280595
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.Q50336935
Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice.Q52535087
Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling.Q52566206
Drosophila Tcf and Groucho interact to repress Wingless signalling activity.Q52566295
Mediator is a transducer of Wnt/beta-catenin signaling.Q52569557
Modulation of oncogenic transcription and alternative splicing by beta-catenin and an RNA aptamer in colon cancer cells.Q53585440
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.Q54660344
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCQ24336321
HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodiesQ24337920
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activationQ24534469
Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1Q24535621
Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complexQ24563333
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activityQ24597019
PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodiesQ24599898
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathwaysQ24647244
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4Q24675969
HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cellsQ24678212
Structural basis for recognition of the intron branch site RNA by splicing factor 1Q27635949
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cellsQ27860717
Lessons from hereditary colorectal cancerQ28131788
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during developmentQ28216579
The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLSQ28262912
Functional interaction of beta-catenin with the transcription factor LEF-1Q28286884
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4Q28592260
The transcriptional coactivator CBP interacts with beta-catenin to activate gene expressionQ28640562
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayQ28640887
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCFQ28645084
Nuclear localization of beta-catenin by interaction with transcription factor LEF-1Q29614379
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleusQ29620188
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complexQ31038919
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]Q31106002
Wnt breakers in colon cancerQ33197185
Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumorsQ33952813
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebratesQ34486253
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomasQ35004950
Tumor formation by genetic mutations in the components of the Wnt signaling pathwayQ35161748
Epigenetic changes in colorectal cancer.Q35682096
Inactivation of the E-cadherin-mediated cell adhesion system in human cancersQ35753235
Regulation of beta -catenin transformation by the p300 transcriptional coactivator.Q35819973
Etoposide: discovery and medicinal chemistryQ35893003
P433issue4
P304page(s)631-637
P577publication date2008-01-02
P1433published inCancer ScienceQ326125
P1476titleWnt signaling inside the nucleus
P478volume99

Reverse relations

cites work (P2860)
Q41367937A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma.
Q33778033Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis
Q39969056Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation
Q35863203Altering cancer transcriptomes using epigenomic inhibitors
Q53211105Alternative splicing within the Wnt signaling pathway: role in cancer development.
Q33907839Brain metastases from lung cancer show increased expression of DVL1, DVL3 and beta-catenin and down-regulation of E-cadherin
Q42176198Ca2+/calmodulin‐stimulated PDE1 regulates the beta‐catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells
Q59798121Cancer Stem Cells: Emergent Nature of Tumor Emergency
Q36378040Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3.
Q26801596Chronic inflammation and the development of malignancy in the GI tract
Q37438687Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1.
Q26865911Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk
Q37966605Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers
Q35530296Functional inhibition of β-catenin-mediated Wnt signaling by intracellular VHH antibodies
Q45954140Going with the Wnt? Focus on "Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC".
Q24312550Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression
Q57468706HPV-18 E6 Oncoprotein and Its Spliced Isoform E6*I Regulate the Wnt/β-Catenin Cell Signaling Pathway through the TCF-4 Transcriptional Factor
Q52374120Human Gut Microbiota and Gastrointestinal Cancer.
Q41090566IL-6 variant is associated with metastasis in breast cancer patients.
Q37260274Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients
Q38722382Inference of hierarchical regulatory network of TCF7L2 binding sites in MCF7 cell line
Q33560729Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth
Q28481465Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway
Q41904328Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis
Q35930474MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways
Q37793987Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes
Q30442237Neurodevelopment in schizophrenia: the role of the wnt pathways
Q39627462PKM2: a new player in the β-catenin game
Q37998994Rho GTPase signaling in the development of colorectal cancer
Q43242602Stem cells might participate in the cell turnover of duodenal adenomas.
Q34720607T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis
Q39733618TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling
Q37223261TNIK inhibition abrogates colorectal cancer stemness
Q34555251Targeting stem cells-clinical implications for cancer therapy
Q34516725The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy
Q47303572The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation.
Q52782861The emergence of TNIK as a therapeutic target for colorectal cancer.
Q37919693The regulation of valvular and vascular sclerosis by osteogenic morphogens
Q34880355The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.
Q34074375Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation
Q33959150Upregulation of SPRR3 promotes colorectal tumorigenesis
Q28303536Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone
Q39637423Wnt/β-catenin signaling is stimulated by α-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiation
Q34055717miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop.
Q37699951miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/β-Catenin Pathway in Tongue Squamous Cell Carcinoma.
Q90616207β-Catenin mutations as determinants of hepatoblastoma phenotypes in mice
Q36144844β-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells
Q24299284β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells