Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway

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Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...733021B
P356DOI10.1371/JOURNAL.PONE.0033021
P3181OpenCitations bibliographic resource ID1285426
P932PMC publication ID3302780
P698PubMed publication ID22427932
P5875ResearchGate publication ID221716343

P50authorMauro PicardoQ56655049
Barbara BelleiQ56872688
P2093author name stringEnzo Izzo
Angela Pitisci
P2860cites workFunctional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genesQ24312718
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Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmiaQ24523673
The selectivity of protein kinase inhibitors: a further updateQ24654622
Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiationQ24678033
Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndromeQ28143572
A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytesQ28204096
Phosphorylated CREB binds specifically to the nuclear protein CBPQ28265019
Melanin pigmentation in mammalian skin and its hormonal regulationQ28283615
Functional interaction of beta-catenin with the transcription factor LEF-1Q28286884
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligandsQ28369113
Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factorQ28509336
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleusQ29620188
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complexQ31038919
ICG-001, a novel small molecule regulator of TCF/beta-catenin transcriptionQ33247340
p38 regulates pigmentation via proteasomal degradation of tyrosinaseQ33748070
Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ.Q33880057
SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibitionQ33996875
Terminal differentiation and senescence in the human melanocyte: repression of tyrosine-phosphorylation of the extracellular signal-regulated kinase 2 selectively defines the two phenotypesQ34442407
Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.Q34484412
Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanomaQ34603059
Human skin pigmentation: melanocytes modulate skin color in response to stressQ34604894
Enzymatic control of pigmentation in mammalsQ34631385
The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: mechanisms underlying its suppression of melanocyte function and proliferationQ50460139
Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.Q52169523
Wnt signalling required for expansion of neural crest and CNS progenitors.Q52192233
In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoterQ61350356
Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-cateninQ34786597
Wnt-frizzled signaling in neural crest formationQ35032124
Quinone chemistry and melanogenesisQ35707913
Investigating Wnt signaling: a chemogenomic safariQ36294110
Regulation of Wnt signaling by protein-protein interaction and post-translational modificationsQ36415188
Regulation of human skin pigmentation and responses to ultraviolet radiationQ36717406
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1αQ36926447
Phospho-regulation of Beta-catenin adhesion and signaling functions.Q36967628
Wnt signaling inside the nucleusQ37051434
Targeting Wnt signaling: can we safely eradicate cancer stem cells?Q37763415
The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivatorsQ37797633
Genomic effects of polyamide/DNA interactions on mRNA expressionQ38363969
Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanogenesisQ38784165
The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expressionQ39128321
Wnt/β-catenin signaling is stimulated by α-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiationQ39637423
Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190.Q39865994
p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3betaQ39926291
GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytesQ39965083
Additive effects of heat and p38 MAPK inhibitor treatment on melanin synthesisQ40110474
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitinationQ40366558
Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expressionQ40443907
Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma.Q40448177
Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanismQ40620736
The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathwayQ40858871
The tyrosinase gene family--interactions of melanogenic proteins to regulate melanogenesisQ41504813
Neuroendocrine activity of the melanocyteQ41959332
β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesisQ42860097
Potentiation of cyclic AMP and cyclic GMP accumulation by p38 mitogen-activated protein kinase (p38MAPK) inhibitors in rat pinealocytesQ43832290
Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1.Q44016906
Inhibition of nucleoside transport by p38 MAPK inhibitorsQ44036947
Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switchingQ45736971
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e33021
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleInhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway
P478volume7

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cites work (P2860)
Q38210121MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation
Q90636643Melanogenic Difference Consideration in Ethnic Skin Type: A Balance Approach Between Skin Brightening Applications and Beneficial Sun Exposure
Q36257963N-(4-methoxyphenyl) caffeamide-induced melanogenesis inhibition mechanisms
Q47142601Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity.
Q36469025SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3' untranslated region in macrophages independently of its effect on p38 MAPK activity
Q26747625Skin Pigmentation and Pigmentary Disorders: Focus on Epidermal/Dermal Cross-Talk
Q58101020Synergistic effect of rice bran extract and extremely low-frequency electromagnetic fields on dermal papilla/melanocytes in melanogenesis
Q46975215The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation
Q89869922The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis
Q28272557Tyrosinase inhibitors: a patent review (2011-2015)

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