| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2016NatCo...712586M |
| P356 | DOI | 10.1038/NCOMMS12586 |
| P932 | PMC publication ID | 5007443 |
| P698 | PubMed publication ID | 27562646 |
| P50 | author | Mutsuko Kukimoto-Niino | Q56451941 |
| Masaaki Sawa | Q88205687 | ||
| Tesshi Yamada | Q88326275 | ||
| P2093 | author name string | Koji Okamoto | |
| Mikako Shirouzu | |||
| Mari Masuda | |||
| Tomoko Inoue | |||
| Hideki Moriyama | |||
| Yuko Uno | |||
| Naoko Goto | |||
| Shigeki Kashimoto | |||
| Naomi Ohbayashi | |||
| Ayako Mimata | |||
| Hirokazu Ohata | |||
| P2860 | cites work | Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling | Q24316697 |
| The kinase TNIK is an essential activator of Wnt target genes | Q24323107 | ||
| Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC | Q24336321 | ||
| Comprehensive molecular characterization of human colon and rectal cancer | Q24630415 | ||
| Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis | Q24645253 | ||
| MolProbity: all-atom structure validation for macromolecular crystallography | Q24649111 | ||
| Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1 | Q24651576 | ||
| PHENIX: a comprehensive Python-based system for macromolecular structure solution | Q24654617 | ||
| Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28 | Q26991723 | ||
| A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. | Q27851748 | ||
| XDS | Q27860472 | ||
| Coot: model-building tools for molecular graphics | Q27860505 | ||
| Epithelial-mesenchymal transitions in development and disease | Q27860630 | ||
| A human colon cancer cell capable of initiating tumour growth in immunodeficient mice | Q27860831 | ||
| Wnt signaling and cancer | Q27860871 | ||
| Phasercrystallographic software | Q27860930 | ||
| The CCP4 suite: programs for protein crystallography | Q27861090 | ||
| Dynamics-Driven Allostery in Protein Kinases | Q28081279 | ||
| Lessons from hereditary colorectal cancer | Q28131788 | ||
| APC mutations occur early during colorectal tumorigenesis | Q28274764 | ||
| Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway | Q28505373 | ||
| Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer | Q28506447 | ||
| Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 | Q28592260 | ||
| Regulation of Wnt signaling by the nuclear pore complex | Q46624298 | ||
| Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling. | Q50930628 | ||
| Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells. | Q53143685 | ||
| Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors | Q74027614 | ||
| A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells | Q28645935 | ||
| Linking colorectal cancer to Wnt signaling | Q29619810 | ||
| A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected] | Q31106002 | ||
| Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis | Q33410679 | ||
| Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer | Q33700204 | ||
| Alternative mammalian target of rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based pathway profiling | Q33718695 | ||
| Patient-derived xenografts, the cancer stem cell paradigm, and cancer pathobiology in the 21st century | Q34037747 | ||
| Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation | Q34074375 | ||
| Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations | Q34179347 | ||
| Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors | Q34323825 | ||
| The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor | Q34384112 | ||
| Self-renewal as a therapeutic target in human colorectal cancer. | Q34388958 | ||
| A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells | Q35357838 | ||
| Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer | Q35762264 | ||
| Regulatory networks in embryo-derived pluripotent stem cells | Q36287880 | ||
| Wnt/beta-catenin signaling in cancer stemness and malignant behavior | Q36738603 | ||
| Wnt signaling inside the nucleus | Q37051434 | ||
| TCF7L2 genetic defect and type 2 diabetes | Q37150525 | ||
| Human colon cancer stem cells: a new paradigm in gastrointestinal oncology | Q37186422 | ||
| Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. | Q37395251 | ||
| Apoptosis and APC in colorectal tumorigenesis | Q37452369 | ||
| The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength | Q37608193 | ||
| TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function | Q37690413 | ||
| Colon cancer stem cells: promise of targeted therapy. | Q37737414 | ||
| Safely targeting cancer stem cells via selective catenin coactivator antagonism | Q38224211 | ||
| Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis | Q38297807 | ||
| Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. | Q39227849 | ||
| Diagnostic and prognostic significance of the alternatively spliced ACTN4 variant in high-grade neuroendocrine pulmonary tumours | Q39298771 | ||
| Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase. | Q39481638 | ||
| Enormous influence of TNIK knockdown on intracellular signals and cell survival | Q39516790 | ||
| Combined functional genome survey of therapeutic targets for hepatocellular carcinoma | Q39715163 | ||
| Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing. | Q40154769 | ||
| The essential role of TNIK gene amplification in gastric cancer growth | Q42177839 | ||
| Activity-based kinase profiling of approved tyrosine kinase inhibitors | Q42713576 | ||
| Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth | Q43041589 | ||
| Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice | Q44342260 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | colorectal cancer | Q188874 |
| colorectal carcinoma | Q25493920 | ||
| P304 | page(s) | 12586 | |
| P577 | publication date | 2016-08-26 | |
| P1433 | published in | Nature Communications | Q573880 |
| P1476 | title | TNIK inhibition abrogates colorectal cancer stemness | |
| P478 | volume | 7 |
| Q64072034 | Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target |
| Q91728270 | Colon cancer stem cells: Potential target for the treatment of colorectal cancer |
| Q55411157 | Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. |
| Q39085740 | Determinants of metastatic competency in colorectal cancer |
| Q33738834 | Emergence of TNIK inhibitors in cancer therapeutics |
| Q47215094 | Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting |
| Q55383144 | JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. |
| Q94460537 | LncRNA WT1-AS over-expression inhibits non-small cell lung cancer cell stemness by down-regulating TGF-β1 |
| Q103002435 | Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846 |
| Q89140538 | Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases |
| Q91709068 | Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma |
| Q91522152 | TNIK signaling imprints CD8+ T cell memory formation early after priming |
| Q90290409 | The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells |
| Q52782861 | The emergence of TNIK as a therapeutic target for colorectal cancer. |
| Q93159737 | The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway |
| Q37735627 | Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications |
| Q49547317 | β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models |
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