Emerging monoclonal antibody therapies for malignant gliomas

scientific article published on April 2007

Emerging monoclonal antibody therapies for malignant gliomas is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1517/13543784.16.4.477
P698PubMed publication ID17371196

P2093author name stringJohn Laterra
David E Gerber
P2860cites workGenes expressed in human tumor endotheliumQ24290105
Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal modelsQ24629814
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesisQ24683896
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.Q27824850
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Improving the efficacy of antibody-based cancer therapiesQ28208361
Clinical impact and functional aspects of tenascin-C expression during glioma progressionQ28211100
Met, metastasis, motility and moreQ28235183
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumorsQ28295039
Molecular regulation of vessel maturationQ29614540
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesisQ29620559
EGFRvIII as a promising target for antibody-based brain tumor therapyQ34157678
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancerQ34323659
Intraventricular Immunotoxin Therapy for Leptomeningeal NeoplasiaQ48598762
Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: A phase II trialQ48602872
Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomasQ48674565
Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugatesQ48676851
Intratumoral infusion of the monoclonal antibody, mAb 425, against the epidermal-growth-factor receptor in patients with advanced malignant gliomaQ48712757
Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patientsQ48883553
Disruption of intracerebral progression of C6 rat glioblastoma by in vivo treatment with anti-CD44 monoclonal antibodyQ52537485
MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy.Q55470198
Treatment of high-grade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h-R3: report from a phase I/II trial.Q55470352
Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.Q55470691
Patterns of failure following high-dose 3-D conformal radiotherapy for high-grade astrocytomas: a quantitative dosimetric study.Q55477123
The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapyQ34325749
Arming antibodies: prospects and challenges for immunoconjugatesQ34449555
Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymomaQ34507174
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooptionQ34997337
Vascular gene expression in nonneoplastic and malignant brain.Q35103013
Classification of glioblastoma multiforme in adults by molecular geneticsQ35144463
Unarmed, tumor-specific monoclonal antibody effectively treats brain tumorsQ35162055
Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: growth factor and Ras signaling pathwaysQ35576159
Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesisQ35641225
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicityQ35660849
Targeted radiotherapy of brain tumoursQ35745251
Monoclonal antibodies for brain tumour treatmentQ35873775
Progress report on the potential of angiogenesis inhibitors for neuro-oncologyQ35964419
Treatment of recurrent and cystic malignant gliomas by a single intracavity injection of 131I monoclonal antibody: feasibility, pharmacokinetics and dosimetryQ35975895
Designing antibodies for oncologyQ36366536
Antibodies and their fragments as anti-cancer agentsQ36384951
VEGF inhibitors in cancer therapyQ36384960
Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agentsQ36395924
Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumoursQ36400537
Molecular biology of epidermal growth factor receptor inhibition for cancer therapyQ36481002
Pretargeted adjuvant radioimmunotherapy with yttrium-90-biotin in malignant glioma patients: a pilot studyQ36643720
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's diseaseQ37118356
Distribution of labelled anti-tenascin antibodies and fragments after injection into intact or partly resected C6-gliomas in ratsQ39695964
Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma modelQ40314272
Immunotoxin treatment targeted to the high-molecular-weight melanoma-associated antigen prolonging the survival of immunodeficient rats with invasive intracranial human glioblastoma multiformeQ40566621
Direct Injection of 90Y MoAbs into Glioma Tumor Resection Cavities Leads to Limited Diffusion of the Radioimmunoconjugates into Normal Brain Parenchyma: A Model to Estimate Absorbed Radiation DoseQ40864219
Scatter factor promotes motility of human glioma and neuromicrovascular endothelial cellsQ41071769
Human glioma-specific antigens detected by monoclonal antibodiesQ41630487
Human antiglioma monoclonal antibodies from patients with astrocytic tumorsQ41631779
Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factorQ41983673
Phase I clinical evaluation of a neutralizing monoclonal antibody against epidermal growth factor receptor in advanced brain tumor patients: preliminary studyQ43631352
131I radioconjugated antibodies for the locoregional radioimmunotherapy of high-grade malignant glioma--phase I and II studyQ43808450
Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivoQ46067245
Complement activation determines the therapeutic activity of rituximab in vivo.Q47745204
Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of maligQ48133104
Expression of tenascin-C in various human brain tumors and its relevance for survival in patients with astrocytomaQ48136909
Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude miceQ48164496
Radioimmunoscintigraphy of intracranial glioma xenograft with a technetium-99m-labeled mouse monoclonal antibody specifically recognizing type III mutant epidermal growth factor receptorQ48238155
Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotinQ48238648
Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinomaQ48291216
Expression of tenascin in human gliomas: its relation to histological malignancy, tumor dedifferentiation and angiogenesisQ48391355
(131)I-chTNT-1/B mAb: tumour necrosis therapy for malignant astrocytic gliomaQ48586802
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmonoclonal antibodyQ422248
P304page(s)477-494
P577publication date2007-04-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titleEmerging monoclonal antibody therapies for malignant gliomas
P478volume16

Reverse relations

cites work (P2860)
Q36922469Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces
Q42364589Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model
Q38088310Preclinical development of therapeutic biologics.
Q30487878Progress and problems in the application of focused ultrasound for blood-brain barrier disruption
Q40092564REST regulates oncogenic properties of glioblastoma stem cells
Q37079078Stereotaxic administrations of allogeneic human Vγ9Vδ2 T cells efficiently control the development of human glioblastoma brain tumors.
Q37174938Use of antibodies and immunoconjugates for the therapy of more accessible cancers