Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis

scientific article published on February 2004

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1586/14737140.4.1.105
P698PubMed publication ID14748662

P2093author name stringHerbert B Newton
P2860cites workAkt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesisQ24313372
Small molecule modulation of Smoothened activityQ24540343
Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedQ24682703
TOR, a central controller of cell growthQ27933354
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamineQ28138510
NF-kappaB is a target of AKT in anti-apoptotic PDGF signallingQ28144330
Regulation of cell death protease caspase-9 by phosphorylationQ28288607
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationQ28290083
Identification of an amplified, highly expressed gene in a human gliomaQ28300727
Expression and distribution of vascular endothelial growth factor protein in human brain tumorsQ28304035
Cellular survival: a play in three AktsQ29547806
The phosphatidylinositol 3-Kinase AKT pathway in human cancerQ29547860
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinomaQ29615947
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionQ29618388
Continuous release of endostatin from microencapsulated engineered cells for tumor therapyQ31793485
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cellsQ32084034
Preclinical and clinical studies of MMP inhibitors in cancerQ33692931
Local endostatin treatment of gliomas administered by microencapsulated producer cellsQ33929689
Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein ComplexQ34101673
Clinical translation of angiogenesis inhibitorsQ34152769
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapyQ34157098
Malignant glioma: genetics and biology of a grave matter.Q34272357
The rapamycin-sensitive signal transduction pathway as a target for cancer therapyQ34293622
PKB/AKT: functional insights from genetic modelsQ34389540
Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential.Q34439772
Mechanisms and future directions for angiogenesis-based cancer therapiesQ34849057
A novel pathway regulating the mammalian target of rapamycin (mTOR) signalingQ34863186
Growth factors and cancerQ36441643
Function and regulation of ras.Q40835314
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.Q41120735
Glioma invasion in the central nervous systemQ41131785
smoothened encodes a receptor-like serpentine protein required for hedgehog signallingQ42633905
Medulloblastoma growth inhibition by hedgehog pathway blockadeQ44119270
Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomasQ48486587
P433issue1
P304page(s)105-128
P577publication date2004-02-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inExpert Review of Anticancer TherapyQ2999044
P1476titleMolecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis
P478volume4

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cites work (P2860)
Q34000631Advances in strategies to improve drug delivery to brain tumors
Q24655510Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
Q42426022Akt2 and Akt3 play a pivotal role in malignant gliomas
Q40379752An in vitro study on the suppressive effect of glioma cell growth induced by plasmid-based small interference RNA (siRNA) targeting human epidermal growth factor receptor
Q34568628Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model
Q33760569Brain angiogenesis in developmental and pathological processes: mechanism and therapeutic intervention in brain tumors
Q46678485CD117 expression in glial tumors
Q36677119Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion
Q36307802Chemotherapy for malignant glioma
Q37316986Combination therapy for malignant glioma based on PTEN status
Q39143478Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling
Q38401892Current strategies for targeted delivery of bio-active drug molecules in the treatment of brain tumor
Q36429731Cytotoxic and molecular chemotherapy for high-grade glioma: an emerging strategy for the future
Q33907663Cytotoxic autophagy in cancer therapy
Q36764016Emerging monoclonal antibody therapies for malignant gliomas
Q36779651Emerging treatments and gene expression profiling in high-risk medulloblastoma
Q46427095Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue
Q45857497Gene therapy for malignant glioma
Q37974419General and neurological complications of targeted therapy
Q57720217Genetics of Pten Hamartoma Tumor Syndrome (PHTS)
Q81521004Glioblastoma multiforme
Q49719103Glioma infiltration and extracellular matrix: key players and modulators.
Q36033617Hedgehog Signaling Components Are Expressed in Choroidal Neovascularization in Laser-induced Retinal Lesion
Q35800467Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
Q36764876Inhibiting kinases in malignant gliomas
Q37004664Inhibition of angiogenesis and invasion in malignant gliomas
Q35440540Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.
Q38089834Malignant glioma drug discovery – targeting protein kinases
Q79969984Malignant gliomas
Q36499234Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment
Q37018652Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors
Q34631513Molecular Targets and Treatment of Meningioma
Q36478640Molecular biology of human gliomas
Q36066191Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. Part 4: p53 signaling pathway
Q36118431Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. Part 5: apoptosis and cell cycle
Q36582396Molecular therapies for malignant glioma
Q33644407Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies
Q36817109Molecularly targeted therapies for malignant gliomas: advances and challenges
Q37364700New strategies to deliver anticancer drugs to brain tumors
Q33747041Notch signaling in glioblastoma: a developmental drug target?
Q38569802Novel chemotherapeutics and other therapies for treating high-grade glioma
Q37808385PI3Kinase signaling in glioblastoma
Q51597378PTEN gene: a model for genetic diseases in dermatology.
Q26784590Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling
Q34886884Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.
Q37444920Present and potential future adjuvant issues in high-grade astrocytic glioma treatment.
Q34191508Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas
Q48413426Relationship between PTEN gene expression and differentiation of human glioma
Q54384404Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells
Q36108621Small molecule and monoclonal antibody therapies in neurooncology
Q34132781Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies
Q33780701Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3
Q45855175Suppression of EGFR expression by antisense or small interference RNA inhibits U251 glioma cell growth in vitro and in vivo
Q82494790Targeted molecular therapy of malignant gliomas
Q36113026Targeted molecular therapy of malignant gliomas
Q35234447Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin.
Q79635149The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells
Q36485266The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas

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