Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).

scientific article published on March 2013

Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/TOXSCI/KFT033
P932PMC publication ID3627556
P698PubMed publication ID23457120
P5875ResearchGate publication ID235778094

P2093author name stringHaibin Zhang
James J Pestka
Hui-Ren Zhou
Brenna Flannery
Jane E Link
Melissa A Bates
Steven J Bursian
Wenda Wu
P2860cites workThe discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptorQ84624399
Distribution of 5-hydroxytryptamine (serotonin, enteramine) in the wall of the digestive tractQ24544046
Central neurocircuitry associated with emesisQ28212287
Distribution of pancreatic polypeptide and peptide YYQ28217249
The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticityQ28244059
Use of intravenous microdialysis to monitor changes in serotonin release and metabolism induced by cisplatin in cancer patients: comparative effects of granisetron and ondansetronQ28376551
The food-contaminant deoxynivalenol modifies eating by targeting anorexigenic neurocircuitryQ28743954
Effect of processing on Fusarium mycotoxins.Q33639631
Central mechanisms of vomiting.Q33734237
The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weightQ33835949
Serotonin: a mediator of the brain-gut connectionQ34070408
Neurochemistry and neuropharmacology of emesis - the role of serotoninQ34088863
Gut hormone PYY(3-36) physiologically inhibits food intakeQ34143493
Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actionsQ34567394
Effects of cholecystokinin-8s in the nucleus tractus solitarius of vagally deafferented ratsQ34708002
The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cellsQ34783985
Characterization of deoxynivalenol-induced anorexia using mouse bioassayQ35070893
Predicting the emetic liability of novel chemical entities: a comparative studyQ36025372
PYY(3-36) induces Fos in the arcuate nucleus and in both catecholaminergic and non-catecholaminergic neurons in the nucleus tractus solitarius of ratsQ36416123
A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosaQ36419333
Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases.Q36429871
Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenolQ36509050
Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YYQ36752713
Tissue distribution and proinflammatory cytokine gene expression following acute oral exposure to deoxynivalenol: comparison of weanling and adult miceQ37050091
Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouseQ37227550
Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonistsQ37761329
Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevanceQ37783539
Neural mechanisms of emesisQ37905191
Regulatory peptides and the onset of nausea and vomiting.Q37905202
Area postrema: chemoreceptor circumventricular organ of the medulla oblongataQ38646128
The neurophysiology of vomitingQ39647441
Emetic and refusal activity of deoxynivalenol to swineQ40074518
Isolation of the emetic principle from Fusarium-infected cornQ40728837
Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in miceQ41831322
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptorQ42463764
Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanismQ42727255
Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink.Q43145965
Antiemetic effect of Xiao-Ban-Xia-Tang, a Chinese medicinal herb recipe, on cisplatin-induced acute and delayed emesis in minksQ43185388
Plasma levels of peptide YY correlate with cisplatin-induced emesis in dogsQ43416084
Plasma hormone levels and central c-Fos expression in ferrets after systemic administration of cholecystokinin.Q43738036
Slowing intestinal transit by PYY depends on serotonergic and opioid pathwaysQ44344804
Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swineQ44746698
Neurons in the nucleus of the solitary tract mediating inputs from emetic vagal afferents and the area postrema to the pattern generator for the emetic act in dogsQ44971610
Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks.Q46029360
The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathwayQ46464837
Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferretsQ46633848
Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaquesQ46774728
Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adultsQ47298315
Cholecystokinin stimulates gonadotropin-releasing hormone release in the monkey (Macaca mulatta).Q48311666
Endogenous cholecystokinin reduces food intake and increases Fos-like immunoreactivity in the dorsal vagal complex but not in the myenteric plexus by CCK1 receptor in the adult rat.Q48379863
The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in ratsQ49036890
The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxietyQ50122116
Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat.Q51556502
Distribution of peripherally injected peptide YY ([125I] PYY (3-36)) and pancreatic polypeptide ([125I] hPP) in the CNS: enrichment in the area postrema.Q51898125
Overt signs of toxicity to dogs and cats of dietary deoxynivalenol.Q52177412
The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents.Q52516709
Effects of PYY1–36 and PYY3–36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjectsQ58448409
5-Hydroxytryptamine in the Circulation of the DogQ59053681
Mysterious outbreaks of gastrointestinal illness associated with burritos supplied through school lunch programsQ64130418
The CCK-A receptor antagonist, devazepide, blocks the anorectic action of CCK but not peripheral serotonin in ratsQ67591186
Identification and characterization of the emetic effects of peptide YYQ69658041
Antiemetic properties of the 5HT3-receptor antagonist, GR38032FQ70047869
The effect of deoxynivalenol on serotoninergic neurotransmitter levels in pig bloodQ71661418
Metabolism and disposition of 14C-granisetron in rat, dog and man after intravenous and oral dosingQ72122579
The efficacy of various classes of anti-emetics in preventing deoxynivalenol-induced vomiting in swineQ72385987
Outbreaks of gastrointestinal illness of unknown etiology associated with eating burritos--United States, October 1997-October 1998Q74659185
Distribution of serotonin (5-hydroxytryptamine) in the human gastrointestinal tractQ78991060
Effects of PYY[3-36] in rodent models of diabetes and obesityQ80201001
Peripheral administration of PYY(3-36) produces conditioned taste aversion in miceQ80959476
P433issue1
P921main subjectdeoxynivalenolQ420518
P304page(s)186-195
P577publication date2013-03-01
P1433published inToxicological SciencesQ2446966
P1476titlePeptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).
P478volume133