Predicting the emetic liability of novel chemical entities: a comparative study

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Predicting the emetic liability of novel chemical entities: a comparative study is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2011.01669.X
P932PMC publication ID3372835
P698PubMed publication ID21913900
P5875ResearchGate publication ID51633917

P50authorNathalie Percie du SertQ43237313
P2093author name stringAnthony M Holmes
Rob Wallis
Paul Lr Andrews
P2860cites workPreferred reporting items for systematic reviews and meta-analyses: the PRISMA statementQ21562278
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypesQ28208581
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal researchQ29547313
The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D.Q34107082
Guide to Receptors and Channels (GRAC), 5th editionQ34228968
Dopamine D2, but not D4, receptor agonists are emetogenic in ferretsQ34418906
Prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus ConferenceQ34562944
Toxicology of Ipecac: A ReviewQ36070464
Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases.Q36429871
American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006.Q36485520
Principles of safety pharmacologyQ36801850
Opportunities for the replacement of animals in the study of nausea and vomitingQ37332618
Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonistsQ37761329
The translational value of rodent gastrointestinal functions: a cautionary tale.Q37870550
A review of clinical trials of lithium in medicineQ38583452
Area postrema: chemoreceptor circumventricular organ of the medulla oblongataQ38646128
Guidelines for reporting experiments involving animals: the ARRIVE guidelinesQ39512979
Acute and chronic effects of lithium chloride on physiological and psychological measures in normalsQ39609753
The pharmacology of (-)-nicotine and novel cholinergic channel modulators.Q41188043
Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP PhosphodiesterasesQ41527389
Time-course analysis of pica in rats using an automatic feeding monitoring systemQ43069546
The delayed phase of cisplatin-induced emesis is mediated by the area postrema and not the abdominal visceral innervation in the ferretQ43280495
Effectiveness of lithium in children and adolescents with conduct disorder: a retrospective naturalistic study.Q43538088
Action of glucocorticoids to antagonise cisplatin-induced acute and delayed emesis in the ferret.Q43596371
Plasma hormone levels and central c-Fos expression in ferrets after systemic administration of cholecystokinin.Q43738036
Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in ratsQ44199863
Differential release of vasopressin and oxytocin in response to abdominal vagal afferent stimulation or apomorphine in the ferretQ44494780
The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feedQ45982021
Pretreatment with ondansetron blunts plasma vasopressin increases associated with morphine administration in ferretsQ46726791
Excitation of area postrema neurons by transmitters, peptides, and cyclic nucleotidesQ48120020
Effect of whole body hyperthermia on cis-diamminedichloroplatinum (II)-induced antitumour activity and tissue Pt-distribution: do anaesthetics influence the therapeutic ratio?Q51674397
Influence of the emetic reflex on vasopressin release in manQ67004595
Comparison of gastrointestinal responses to CCK-8 and associated with vomitingQ68281808
Antiemetic properties of the 5HT3-receptor antagonist, GR38032FQ70047869
A new concept of organization of the central emetic mechanism: recent studies on the sites of action of apomorphine, copper sulfate and cardiac glycosidesQ73959330
Emetic action of nicotine and lobelineQ74750935
Copper sulphate emesis; a study of afferent pathways from the gastrointestinal tractQ75669479
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1848-1867
P577publication date2012-03-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titlePredicting the emetic liability of novel chemical entities: a comparative study
P478volume165

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cites work (P2860)
Q4674381714th Annual Meeting of the Safety Pharmacology Society: threading through scientific sessions for originality and novelty
Q57161235A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research
Q46649469An evaluation of the non-invasive faecal pellet assessment method as an early drug discovery screen for gastrointestinal liability
Q47158565Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms
Q47159233Appropriateness to set a group health based guidance value for nivalenol and its modified forms
Q35159856Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.
Q36509050Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol
Q46477578Comparison of three preclinical models for nausea and vomiting assessment
Q41949833Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret.
Q46240693Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles
Q50433260Everyday memory: towards a translationally effective method of modelling the encoding, forgetting and enhancement of memory.
Q36769372Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).
Q64241539Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus
Q58721628Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder
Q28650531Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs)
Q35635673The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease
Q38209000The role of the parasympathetic nervous system in visually induced motion sickness: systematic review and meta-analysis
Q42594722Using telemetry to automate the detection of emesis in the ferret: new vistas for delayed emesis assessment

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