| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | John A Rudd | Q59693084 |
| P2093 | author name string | Q Aziz | |
| J A Rudd | |||
| P L R Andrews | |||
| A M Holmes | |||
| F D Tattersall | |||
| P2860 | cites work | PDE4 inhibitors: current status | Q24651926 |
| Physiological basis and pharmacology of motion sickness: an update | Q28138034 | ||
| Central neurocircuitry associated with emesis | Q28212287 | ||
| The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity | Q28244059 | ||
| Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing | Q28273361 | ||
| Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin | Q28292978 | ||
| BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation | Q28305961 | ||
| In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators | Q28471679 | ||
| Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells | Q28587646 | ||
| Functional brain imaging of gastrointestinal sensation in health and disease | Q30431498 | ||
| Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans | Q31051911 | ||
| Functional cortical imaging of nausea and vomiting: a possible approach | Q31058353 | ||
| PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway | Q31679675 | ||
| Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands. | Q33251201 | ||
| Breaking down the barriers: fMRI applications in pain, analgesia and analgesics | Q33257909 | ||
| Guidelines for anti-emetic therapy: acute emesis | Q33711620 | ||
| I. The Reaction to Posterior Pituitary Extract (Pituitrin) When Introduced into the Cerebral Ventricles | Q33738483 | ||
| Emetic action of nicotine and lobeline | Q74750935 | ||
| Methotrexate produces delayed emesis in dogs: a potential model of delayed emesis induced by chemotherapy | Q77965259 | ||
| Use of behavior analysis to recognize pain in small mammals | Q80371208 | ||
| Motion sickness | Q81284918 | ||
| Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance | Q82309713 | ||
| Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers | Q82836198 | ||
| Betamethasone does not prevent nausea and vomiting induced by the dopamine-agonist apomorphine | Q83019549 | ||
| The evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man | Q93795546 | ||
| Volunteer studies in pain research — Opportunities and challenges to replace animal experiments | Q60678794 | ||
| Pica—A model of nausea? Species differences in response to cisplatin | Q61694390 | ||
| An Apomorphine-Induced Vomiting Model for Antiemetic Studies in Man | Q67266452 | ||
| Emesis, Radiation Exposure, and Local Cerebral Blood Flow in the Ferret | Q68379770 | ||
| Characterization of radiation-induced emesis in the ferret | Q68379794 | ||
| Central mechanisms for apomorphine-induced emesis in the dog | Q68671274 | ||
| Suncus murinus: a new experimental model in emesis research | Q69075353 | ||
| Antiemetic effect of metoclopramide...evaluation in humans | Q69841528 | ||
| Responses of plasma oxytocin and arginine vasopressin to nausea induced by apomorphine and ipecacuanha | Q69924386 | ||
| Apomorphine-induced vomiting in rainbow trout (Salmo gairdneri) | Q69931663 | ||
| Vasopressin release in response to nausea-producing agents and cholecystokinin in monkeys | Q70173152 | ||
| Pica in rats is analogous to emesis: an animal model in emesis research | Q70519103 | ||
| The special role of nausea in the acquisition of food dislikes by humans | Q70585612 | ||
| The apomorphine antagonism test in dogs. Experimental evidence and critical considerations on specific methodological criteria | Q70678498 | ||
| Human cortical activity during vestibular- and drug-induced nausea detected using MSI | Q71225868 | ||
| The alpha-naphthoxyacetic acid-elicited retching involves dopaminergic inhibition in mice | Q71250156 | ||
| Effects of N-methyl-D-aspartate receptor antagonists on cisplatin-induced emesis in the ferret | Q71504436 | ||
| The pharmacology of the emetic response to upper gastrointestinal tract stimulation in Suncus murinus | Q71605043 | ||
| Evidence that cisplatin induces serotonin release from human peripheral blood mononuclear cells and that methylprednisolone inhibits this effect | Q71834444 | ||
| The piglet as a suitable animal model for studying the delayed phase of cisplatin-induced emesis | Q71962808 | ||
| Toxicology screening in small animals | Q72011175 | ||
| Ipecacuanha-induced emesis: a human model for testing antiemetic drug activity | Q72225424 | ||
| Profiles of emetic action of cisplatin in the ferret: a potential model of acute and delayed emesis | Q72389881 | ||
| Differential effects of angiotensin II in the nucleus tractus solitarii of the rat--plausible neuronal mechanism | Q73184422 | ||
| The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew) | Q73393192 | ||
| Probable involvement of the 5-hydroxytryptamine(4) receptor in methotrexate-induced delayed emesis in dogs | Q73478898 | ||
| Influence of chlorpromazine and promethazine on vomiting induced with apomorphine in man | Q73590032 | ||
| The influence of hyoscine and atropine on apomorphine-induced vomiting in man | Q74016573 | ||
| Antiemetics for cancer chemotherapy-induced nausea and vomiting. A review of agents in development | Q33830043 | ||
| Serotonin mediates food-odor associative learning in the nematode Caenorhabditiselegans | Q34156392 | ||
| Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro | Q34215273 | ||
| Volunteer models for predicting antiemetic activity of 5-HT3-receptor antagonists | Q34346342 | ||
| Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial | Q34494637 | ||
| Treatment of nausea and vomiting: gaps in our knowledge. | Q34560699 | ||
| A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models. | Q34686974 | ||
| Pharmacokinetics and brain penetration of casopitant, a potent and selective neurokinin-1 receptor antagonist, in the ferret | Q34786679 | ||
| The diaphragm: two physiological muscles in one. | Q34996412 | ||
| Cisplatin-induced early and delayed emesis in the pigeon | Q35042209 | ||
| Gastrointestinal regulation of food intake | Q35251043 | ||
| Comparative efficacy of antidepressants | Q35326801 | ||
| Brain Fos expression during 48 h after cisplatin treatment: neural pathways for acute and delayed visceral sickness. | Q35781990 | ||
| Gastrointestinal-tract models and techniques for use in safety pharmacology. | Q35789031 | ||
| Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans | Q35844548 | ||
| The anti-emetic effects of CP-99,994 in the ferret and the dog: role of the NK1 receptor | Q35872537 | ||
| Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man. | Q36055217 | ||
| Glucagon-like peptide 1 and its derivatives in the treatment of diabetes. | Q36075988 | ||
| Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. | Q36429871 | ||
| Towards a molecular understanding of human diseases using Dictyostelium discoideum | Q36557111 | ||
| Overshadowing and latent inhibition of context aversion conditioning in the rat. | Q36578736 | ||
| Conditioned gaping in rats: a selective measure of nausea | Q36584774 | ||
| Pharmacology, pharmacogenetics, and clinical efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. | Q36648641 | ||
| Odorant-selective genes and neurons mediate olfaction in C. elegans. | Q36766643 | ||
| Are more antiemetic trials with a placebo necessary? Report of patient data from randomized trials of placebo antiemetics with cisplatin | Q36832481 | ||
| Purinergic P2X receptor activation induces emetic responses in ferrets and Suncus murinus (house musk shrews). | Q39321783 | ||
| Comparative aspects of the area postrema: fine-structural considerations help to determine its function | Q39454847 | ||
| Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'. | Q39959421 | ||
| Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels | Q40278572 | ||
| Nucleus tractus solitarius--gateway to neural circulatory control | Q40623634 | ||
| The severity and pattern of emesis following different cytotoxic agents | Q41023032 | ||
| Nature of receptors involved in apomorphine responses in pigeons | Q41287111 | ||
| The susceptibility of rhesus monkeys to motion sickness | Q41904492 | ||
| Comparison of the effects of a selective muscarinic receptor antagonist and hyoscine (scopolamine) on motion sickness, skin conductance and heart rate | Q42144684 | ||
| Gastrointestinal motor and myoelectric correlates of motion sickness | Q43338377 | ||
| Hormonal effects of apomorphine and cholecystokinin in pigs: modification of the response to cholecystokinin by a dopamine antagonist (metoclopramide) and a kappa opioid agonist (PD117302). | Q43538944 | ||
| Modulation of gastric motor activity by a centrally acting stimulus, circular vection, in humans | Q43568288 | ||
| Plasma hormone levels and central c-Fos expression in ferrets after systemic administration of cholecystokinin. | Q43738036 | ||
| Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret | Q43770448 | ||
| 5-Hydroxytryptamine (5-HT)-induced depolarization in isolated abdominal vagus nerves in the rat: involvement of 5-HT3 and 5-HT4 receptors. | Q43834927 | ||
| Antiemetic Effectiveness of Haloperidol in Human Volunteers Challenged With Apomorphine | Q44193006 | ||
| An arterially perfused decerebrate preparation of Suncus murinus (house musk shrew) for the study of emesis and swallowing | Q44248925 | ||
| Effects of apomorphine and its interaction with other drugs in the domestic fowl | Q44312694 | ||
| Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors | Q44363683 | ||
| The signal to move: D. discoideum go orienteering | Q44469048 | ||
| Ondansetron and Metformin-Induced Gastrointestinal Side Effects | Q44659967 | ||
| Delayed emesis following high-dose cisplatin: a double-blind randomised comparative trial of ondansetron (GR 38032F) versus placebo | Q45100783 | ||
| Betamethasone does not prevent nausea and vomiting induced by ipecacuanha. | Q45123653 | ||
| Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anti-cancer agent cisplatin | Q45126626 | ||
| Long-lasting anti-emetic effect of T-2328, a novel NK(1) antagonist. | Q46165095 | ||
| The effects of cooling the area postrema of male rats on conditioned taste aversions induced by LiC1 and apomorphine | Q46176719 | ||
| Neurobiology of the Caenorhabditis elegans genome. | Q46229602 | ||
| Chemotaxis of the nematode Caenorhabditis elegans toward cycloheximide and quinine hydrochloride. | Q46759246 | ||
| Mutants of the nematode Caenorhabditis elegans that are defective specifically in their attraction to cycloheximide | Q46760308 | ||
| Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. | Q46797779 | ||
| Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans | Q46799015 | ||
| Functional expression of mammalian bitter taste receptors in Caenorhabditis elegans | Q46957951 | ||
| Effect of oral CCK-1 agonist GI181771X on fasting and postprandial gastric functions in healthy volunteers | Q47216631 | ||
| Higher order neurons in buccal ganglia of Pleurobranchaea elicit vomiting motor activity | Q47955428 | ||
| Similarities of the neuronal circuit for the induction of fictive vomiting between ferrets and dogs | Q48179420 | ||
| The tachykinin NK1 receptor antagonist GR205171 prevents vagal stimulation-induced retching but not neuronal transmission from emetic vagal afferents to solitary nucleus neurons in dogs | Q48389709 | ||
| Cerebral activation during vagus nerve stimulation: a functional MR study | Q48435174 | ||
| Real-time measurement of serotonin release and motility in guinea pig ileum | Q48664603 | ||
| Microvascular specializations promoting rapid interstitial solute dispersion in nucleus tractus solitarius | Q48844177 | ||
| Vasopressin and oxytocin responses to illusory self-motion and nausea in man. | Q48867721 | ||
| Neuroendocrine and gastric myoelectrical responses to illusory self-motion in humans | Q49123709 | ||
| EMESIS INDUCED BY INTRACEREBROVENTRICULAR INJECTIONS OF APOMORPHINE AND DESLANOSIDE IN NORMAL AND CHEMORECEPTIVE TRIGGER ZONE ABLATED DOGS | Q51255098 | ||
| A study of the structure of the area postrema with Golgi methods. | Q51306317 | ||
| Role of medullary emetic chemoreceptor trigger zone (CT zone) in postnephrectomy vomiting in dogs. | Q51313298 | ||
| Effect of ablation of medullary emetic chemoreceptor trigger zone on vomiting responses to cerebral intraventricular injection of adrenaline, apomorphine and pilocarpine in the cat. | Q51314734 | ||
| The Chemoreceptor Trigger Zone for Emesis in the Monkey | Q51338357 | ||
| Effects of propofol on ipecacuanha-induced nausea and vomiting. | Q51524828 | ||
| Propofol sedation and gastric emptying in volunteers. | Q51526856 | ||
| The effect of intravenous vasopressin on gastric myoelectrical activity in human subjects. | Q51573217 | ||
| Antiemetic specificity of dopamine antagonists | Q52291183 | ||
| Preclinical safety testing of monoclonal antibodies: the significance of species relevance. | Q53242492 | ||
| Incidence, course, and severity of delayed nausea and vomiting following the administration of high-dose cisplatin. | Q53768861 | ||
| Differential effects of apamin on neuronal excitability in the nucleus tractus solitarii of rats studied in vitro. | Q54026090 | ||
| Chemotherapy-Induced Nausea and Vomiting | Q56657991 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 865-880 | |
| P577 | publication date | 2009-04-09 | |
| P1433 | published in | British Journal of Pharmacology | Q919631 |
| P1476 | title | Opportunities for the replacement of animals in the study of nausea and vomiting | |
| P478 | volume | 157 |
| Q46743817 | 14th Annual Meeting of the Safety Pharmacology Society: threading through scientific sessions for originality and novelty |
| Q57161235 | A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research |
| Q34978498 | A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum. |
| Q48162828 | Alterations in the small intestinal wall and motor function after repeated cisplatin in rat. |
| Q41438817 | Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study. |
| Q39786310 | Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials |
| Q26738288 | Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting |
| Q37761329 | Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonists |
| Q46477578 | Comparison of three preclinical models for nausea and vomiting assessment |
| Q41949833 | Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret. |
| Q42149425 | Employment of a noninvasive magnetic method for evaluation of gastrointestinal transit in rats |
| Q57121953 | Enteric neuropathy evoked by repeated cisplatin in the rat |
| Q46240693 | Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles |
| Q47153467 | Gastric myoelectric activity during cisplatin-induced acute and delayed emesis reveals a temporal impairment of slow waves in ferrets: effects not reversed by the GLP-1 receptor antagonist, exendin (9-39). |
| Q39512979 | Guidelines for reporting experiments involving animals: the ARRIVE guidelines |
| Q35687753 | Human tissue in the evaluation of safety and efficacy of new medicines: a viable alternative to animal models? |
| Q27321366 | Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research |
| Q37625445 | Involvement of Cannabinoid Signaling in Vincristine-Induced Gastrointestinal Dysmotility in the Rat. |
| Q37332614 | Less is more: reducing the reliance on animal models for nausea and vomiting research |
| Q38215005 | Measuring the nausea-to-emesis continuum in non-human animals: refocusing on gastrointestinal vagal signaling |
| Q38276835 | Nausea: current knowledge of mechanisms, measurement and clinical impact. |
| Q38106684 | Pearls and pitfalls in experimental in vivo models of headache: conscious behavioral research |
| Q28650531 | Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs) |
| Q36025372 | Predicting the emetic liability of novel chemical entities: a comparative study |
| Q41842774 | Reduced normogastric electrical activity associated with emesis: a telemetric study in ferrets |
| Q34356067 | Refinement, reduction and replacement approaches to in vivo cardiovascular research |
| Q60638462 | Safety of xylo‐oligosaccharides (XOS) as a novel food pursuant to Regulation (EU) 2015/2283 |
| Q38018818 | The gastrointestinal pharmacology of cannabinoids: focus on motility |
| Q40592723 | The importance of systematic approaches in the study of emesis |
| Q26745801 | The involvement of TRPV1 in emesis and anti-emesis |
| Q38209000 | The role of the parasympathetic nervous system in visually induced motion sickness: systematic review and meta-analysis |
| Q48391867 | Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans. |
| Q38906491 | What is nausea? A historical analysis of changing views. |
| Q48792646 | X-ray analysis of the effect of the 5-HT3 receptor antagonist granisetron on gastrointestinal motility in rats repeatedly treated with the antitumoral drug cisplatin |
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