Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

scientific article published on 14 December 2015

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBR.2015.12.012
P932PMC publication ID4823003
P698PubMed publication ID26698400
P5875ResearchGate publication ID287406622

P50authorKoji FukuiQ55873512
Donald K. IngramQ107733297
P2093author name stringRafael de Cabo
Joanne S Allard
Evelyn J Perez
Priscilla Carpenter
P2860cites workRole of AMP-activated protein kinase in mechanism of metformin actionQ22241898
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Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type miceQ28485110
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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.Q34852281
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Regulation of Nrf2 signaling and longevity in naturally long-lived rodentsQ35229453
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Intracerebroventricular injection of metformin induces anorexia in ratsQ36191735
Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.Q37129434
Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathologyQ37178970
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NGF, BDNF, NT3, and NT4.Q38199407
BDNF and synaptic plasticity, cognitive function, and dysfunctionQ38199414
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Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control studyQ38433563
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Relationship between body fat mass, carbohydrate tolerance and iri response during glucose infusion in subjects with early diabetesQ41658865
Metformin directly acts on mitochondria to alter cellular bioenergetics.Q41897802
Repaglinide/metformin fixed-dose combination to improve glycemic control in patients with type 2 diabetes: an updateQ42253351
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in miceQ42705749
Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharideQ42794498
Metformin improves liver antioxidant potential in rats fed a high-fructose dietQ44258311
Lean mass inversely predicts plasma glucose levels after oral glucose load independent of insulin secretion or insulin sensitivity in glucose intolerance subjectsQ45841055
Improving metabolic control leads to better working memory in adults with type 2 diabetes.Q46917184
Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjectsQ46926316
Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinaseQ47225253
The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expressionQ48266485
A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metforminQ48407108
R D Lawrence Lecture 2010. The brain as a target organ in Type 2 diabetes: exploring the links with cognitive impairment and dementiaQ48541090
Chronic Metformin Preconditioning Provides Neuroprotection via Suppression of NF-κB-Mediated Inflammatory Pathway in Rats with Permanent Cerebral IschemiaQ48575097
Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in miceQ48613553
The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic ratsQ48665393
Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J miceQ48860107
Metformin treatment alters memory function in a mouse model of Alzheimer's disease.Q50636567
Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke.Q51748258
Cortical function in elderly non-insulin dependent diabetic patients. Behavioral and electrophysiologic studies.Q52120884
Decreased cognitive function in aging non-insulin-dependent diabetic patients.Q52209256
Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway.Q54383877
[Absorption, distribution in the organism and elimination of metformin]Q71262502
Accumulation of metformin by tissues of the normal and diabetic mouseQ72381698
Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitusQ72583835
Inhibitory effect of metformin on intestinal glucose absorption in the perfused rat intestineQ73551272
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
cognitive dysfunctionQ57859955
P304page(s)1-9
P577publication date2015-12-14
P1433published inBehavioural Brain ResearchQ3619047
P1476titleProlonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
P478volume301

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