NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent

scientific article published on 28 February 2013

NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.DRUGALCDEP.2013.02.006
P8608Fatcat IDrelease_xr22f2llincbjhufvov4hwgngq
P932PMC publication ID3628730
P698PubMed publication ID23455491
P5875ResearchGate publication ID235776529

P50authorJohn KrystalQ104111313
P2093author name stringFengyu Zhang
Heping Zhang
Chiang-Shan R Li
Xiang-Yang Zhang
Kesheng Wang
Lingjun Zuo
Xingguang Luo
P2860cites workA flexible and accurate genotype imputation method for the next generation of genome-wide association studiesQ21129496
Genome-wide associations of gene expression variation in humansQ21145274
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
Molecular genetics of successful smoking cessation: convergent genome-wide association study resultsQ24653819
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Statistical significance for genomewide studiesQ24681264
The structure of haplotype blocks in the human genomeQ27860500
Identification of a ubiquitous family of membrane proteins and their expression in mouse brain.Q27932213
The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairmentQ28201117
Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) StudyQ28259349
ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studiesQ28278084
Numerous candidate plasticity-related genes revealed by differential cDNA cloningQ28573003
Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesisQ28584014
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implicationsQ28943311
Genome-wide association study of alcohol dependenceQ28943321
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1qQ28943436
Rare variants create synthetic genome-wide associationsQ29614955
Topiramate for treating alcohol dependence: a randomized controlled trialQ30444701
A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokersQ30445797
Tissue-specific genetic control of splicing: implications for the study of complex traitsQ33409947
The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review.Q33716681
A genome-wide association study of alcohol dependenceQ33740277
The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin womenQ33813262
Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Q33907650
Variant between CPT1B and CHKB associated with susceptibility to narcolepsyQ34013921
A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association studyQ34077684
Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependenceQ34287000
Requirement of a critical period of transcription for induction of a late phase of LTP.Q34332490
Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related ConditionsQ34338064
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependenceQ34658282
Lipid rafts in neuronal signaling and function.Q34750258
Candidate genes for alcohol dependence: a review of genetic evidence from human studiesQ35135931
N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerabilityQ35153745
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependenceQ35189955
Rare ADH variant constellations are specific for alcohol dependenceQ36469887
Association between dopamine transporter genotypes and smoking cessation: a meta-analysisQ36825062
Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependenceQ37115461
DRD4 and DAT1 as modifying genes in alcoholism: interaction with novelty seeking on level of alcohol consumption.Q43539785
The DRD4 VNTR polymorphism influences reactivity to smoking cuesQ43897208
Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han.Q44137036
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-AmericansQ44483802
Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent healthQ44739442
Lipid rafts mediate chemotropic guidance of nerve growth conesQ44831769
CNR1 variation modulates risk for drug and alcohol dependenceQ44896757
Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.Q44908892
Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholismQ45276123
Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish populationQ46057910
Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populationsQ46381478
Association of the dopamine transporter gene with alcoholism.Q46582807
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer diseaseQ47596541
Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men.Q50918228
Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine.Q51907944
Association of OPRM1 A118G variant with the relative reinforcing value of nicotine.Q52007326
The epidemiology of co-occurring addictive and mental disorders: implications for prevention and service utilization.Q52011224
An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline.Q52021538
The family based association test method: strategies for studying general genotype--phenotype associations.Q52065297
Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.Q53589822
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Q53834088
Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrixQ57121444
Genetics of alcohol dependenceQ57418861
Activity of Secretory Sphingomyelinase Is Increased in Plasma of Alcohol-Dependent PatientsQ57780123
Inheritance of alcohol abuse. Cross-fostering analysis of adopted menQ70863106
Genome-wide search for genes affecting the risk for alcohol dependenceQ74594088
Maternal alcohol consumption increases sphingosine levels in the brains of progeny miceQ80801093
P433issue3
P921main subjectalcohol dependenceQ4713263
replicabilityQ63285799
P304page(s)254-264
P577publication date2013-02-28
P1433published inDrug and Alcohol DependenceQ5308875
P1476titleNKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
P478volume129

Reverse relations

cites work (P2860)
Q41587969A New Genomewide Association Meta-Analysis of Alcohol Dependence
Q35788318An Efficient Stepwise Statistical Test to Identify Multiple Linked Human Genetic Variants Associated with Specific Phenotypic Traits
Q42362268Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder.
Q48342313Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms.
Q36280198Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence.
Q89863587Discovering weaker genetic associations guided by known associations
Q35740674Gene-based and pathway-based genome-wide association study of alcohol dependence
Q92221733Genetic determinants of beverage consumption: Implications for nutrition and health
Q33681743Genetics and genomics of alcohol sensitivity
Q27003168Genome-wide association discoveries of alcohol dependence
Q34193319Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
Q52316078Human Genetics of Addiction: New Insights and Future Directions.
Q60956918Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls
Q34872499Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent
Q36386564Sex difference of autosomal alleles in populations of European and African descent
Q46186812Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry.
Q40544102The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores
Q34429555XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans

Search more.