The immune system evolved to discriminate infectious nonself from noninfectious self

scientific article published on January 1, 1992

The immune system evolved to discriminate infectious nonself from noninfectious self is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/0167-5699(92)90198-G
P953full work available at URLhttps://api.elsevier.com/content/article/PII:016756999290198G?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:016756999290198G?httpAccept=text/xml
P698PubMed publication ID1739426

P50authorCharles JanewayQ1065040
P2860cites workSequence analysis of peptides bound to MHC class II moleculesQ28303686
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Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbitsQ44370457
Specificity and function of T cells bearing gamma delta receptorsQ44385574
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Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cellsQ46569539
Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patchesQ48232702
A single rearrangement event generates most of the chicken immunoglobulin light chain diversityQ48381680
Microbial induction of co-stimulatory activity for CD4 T-cell growth.Q52099252
Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.Q52244112
A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectivelyQ55888521
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Immunology: The ins and outs of antigen processing and presentationsQ59073630
The Ly-1 B cell lineageQ70312538
Ante-antibody immunityQ80506528
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)11-16
P577publication date1992-01-01
P1433published inTrends in ImmunologyQ15265730
P1476titleThe immune system evolved to discriminate infectious nonself from noninfectious self
P478volume13

Reverse relations

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Q40014914Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4.
Q40398318Porphyromonas gingivalis lipopolysaccharide displays functionally diverse interactions with the innate host defense system
Q34120648Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation
Q99238024Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4
Q34008791Potent stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein
Q37700561Potential of the beta-glucans to enhance innate resistance to biological agents
Q24646220Preeclampsia: a view through the danger model
Q35037363Primary prevention of uterine cervix cancer: focus on vaccine history and current strategy
Q36735401Primer: comparative genetics of animal models of arthritis--a tool to resolve complexity
Q34937622Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period
Q35084902Protection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells
Q37651354Protein bio-corona: critical issue in immune nanotoxicology
Q41392031Purification and characterization of a human membrane protein that activates the alternative complement pathway and allows the deposition of homologous complement C3.
Q36268500Quantitative rules for lymphocyte regulation: the cellular calculus and decisions between tolerance and activation.
Q36363011Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces
Q33813643Rare antibodies from combinatorial libraries suggests an S.O.S. component of the human immunological repertoire
Q37766262Recent insights into the role of Toll-like receptors in viral infection
Q37559669Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins.
Q24530569Recognition of Staphylococcus aureus by the innate immune system
Q37193505Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2.
Q38357758Recombinant bovine conglutinin, lacking the N-terminal and collagenous domains, has less conglutination activity but is able to inhibit haemagglutination by influenza A virus
Q28250469Reflections on the clonal-selection theory
Q34497326Regulated gene expression in gene therapy.
Q45112156Regulation of adaptive immunity by natural killer cells
Q36380889Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells
Q36848047Resistance of MMP9 and TIMP1 to endotoxin tolerance
Q37810600Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design
Q36401161Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
Q41399593Review: Peyer's patches
Q64996238Ribosomal DNA as DAMPs Signal for MCF7 Cancer Cells.
Q25257758Role of TOLL-like Receptors in Adjuvant-Augmented Immune Therapies by T. Seya
Q36404683Role of antigen-presenting cells in mediating tolerance and autoimmunity
Q37754716Role of bacterial infections in allograft rejection
Q36439187Role of bioactivation in drug-induced hypersensitivity reactions
Q36404148Role of the integument in insect immunity: epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells
Q36703949Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease
Q47620008STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.
Q71320499Scavenger receptors in innate immunity
Q38419969Sequential Immune Responses: The Weapons of Immunity
Q77488329Shifting T-cell activation thresholds in autoimmunity and determinant spreading
Q33907293Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis
Q34590044Sialoside-based pattern recognitions discriminating infections from tissue injuries
Q33974526Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity.
Q36325327Some reasons why deletion and anergy do not satisfactorily account for natural tolerance
Q39825128Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages
Q47135720Strategies to Improve the Efficacy of Dendritic Cell-Based Immunotherapy for Melanoma
Q36113326Stress and immunological recognition in host-pathogen interactions
Q27648579Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch
Q24682124Structural insights into the innate immune recognition specificities of L- and H-ficolins
Q27733853Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
Q40903248Structure-function analysis of CD14 as a soluble receptor for lipopolysaccharide
Q39510867Structures in Bacillus subtilis are recognized by CD14 in a lipopolysaccharide binding protein-dependent reaction
Q52589937Surface characteristics of foreign targets that elicit an encapsulation response by the moth Pseudoplusia includens.
Q82570932Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing
Q35192171Survey of human-use adjuvants
Q28005535Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
Q43511256T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.
Q36363017T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells.
Q48238886T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy.
Q43774330T cell tolerance and self/nonself discrimination
Q58793668T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
Q34171890T cell-macrophage interactions and granuloma formation in vasculitis.
Q40746119T cells and thyroid autoimmunity.
Q51913407T cells survey the stability of the self: a testable hypothesis on the homeostatic role of TCR-MHC interactions.
Q36997273T lymphocytes in Sjögren's syndrome: contributors to and regulators of pathophysiology
Q37257085TLR4 polymorphism and periodontitis susceptibility: A meta-analysis
Q79324702TLR5 takes aim at bacterial propeller
Q35593328TLRs and NODs mRNA expression pattern in healthy mouse eye.
Q80504764TLRs in disease
Q24310057TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain
Q74268258Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis
Q34807615Targeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model
Q36041765Temporal and spatial expression of high-mobility group box 1 in surgically injured rat vocal folds
Q33833220Th1/Th2 balance in infection
Q81397226Th1/Th2 polarization by viral and helminth infection in birds
Q36371212The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens
Q40776029The Caenorhabditis elegans p38 MAPK Gene plays a key role in protection from mycobacteria
Q74696144The Clonal Selection Theory: what it really is and why modern challenges are misplaced
Q40147137The Immune Adjuvant Effects of Flounder (Paralichthys olivaceus) Interleukin-6 on E. tarda Subunit Vaccine OmpV.
Q64276875The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer
Q40635862The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-kappaB activation in epithelial cells in a Toll-like receptor 2-dependent manner.
Q89127025The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host's Defense Strategy against Neuroinflammation
Q38880688The Role of Proinflammatory Cytokine Interleukin-18 in Radiation Injury
Q40151249The Role of the Immune System Beyond the Fight Against Infection.
Q46194843The Thymus/Neocortex Hypothesis of the Brain: A Cell Basis for Recognition and Instruction of Self.
Q26859223The activation and inactivation of mature CD4 T cells: a case for peripheral self-nonself discrimination
Q44991707The adaptation model of immunity
Q37685453The alarmin functions of high-mobility group proteins.
Q37943469The antibody response to an HLA mismatch: a model for nonself-self discrimination in relation to HLA epitope immunogenicity
Q40511561The basis of autoimmunity: an overview
Q37008661The biological role of dectin-1 in immune response
Q33922391The biology of Toll-like receptors
Q21131221The danger theory: 20 years later
Q28384138The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity
Q34012447The development of the immune system during pregnancy and early life
Q27001581The effects of TLR activation on T-cell development and differentiation
Q38165257The emerging role of the receptor for advanced glycation end products on innate immunity
Q36407199The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity
Q34573771The enemy within: keeping self-reactive T cells at bay in the periphery
Q59564566The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity
Q34207060The evolutionary context for a self-nonself discrimination
Q92065855The history of the two-signal model of lymphocyte activation: A personal perspective
Q28243940The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells
Q46378486The human macrophage mannose receptor is not a professional phagocytic receptor
Q73983474The immune system's role in graft loss: theoretic considerations
Q42035149The immunoglobulin family protein Hemolin mediates cellular immune responses to bacteria in the insect Manduca sexta
Q35687958The immunological paradox of pregnancy: a reappraisal
Q82182732The impact of CD14 polymorphisms on the development of soluble CD14 levels during infancy
Q33732470The innate immune system in allograft rejection and tolerance
Q34282306The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
Q33887468The macrophage receptor MARCO.
Q36380853The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock
Q28266161The mannose receptor is a pattern recognition receptor involved in host defense
Q36348036The mannose-binding lectin: a prototypic pattern recognition molecule
Q34502370The many roles of the class A macrophage scavenger receptor
Q41754941The microbial challenge in periodontitis
Q38116712The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer
Q37478630The oral microbial consortium's interaction with the periodontal innate defense system
Q40872998The pathobiology of peritonitis
Q74187442The primary IgM antibody repertoire: a source of potent idiotype immunogens
Q80038678The promise of cancer vaccines
Q24803143The quantal theory of how the immune system discriminates between "self and non-self"
Q33599759The regulation of apoptosis by microbial pathogens.
Q38750747The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors
Q28512624The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
Q43895324The role of advanced oxidation protein products in regulation of dendritic cell function
Q26851880The role of mannose-binding lectin in severe sepsis and septic shock
Q37784863The roles of TNF in brain dysfunction and disease
Q41326875The significance of immune suppression in normal self tolerance
Q48291060The small heat shock protein alpha B-crystallin as key autoantigen in multiple sclerosis
Q42233804The teleost acute-phase inflammatory response and caspase activation by a novel alarmin-like ligand
Q40838120The thymus and T-cell tolerance
Q77846814The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
Q26863283Therapeutic cancer vaccines: past, present, and future
Q38270021Thoughts engendered by Bretscher's Two-step, Two-signal model for a peripheral self-non-self discrimination and the origin of primer effector T helpers
Q37638199Tissue-mediated control of immunopathology in coeliac disease
Q33840545Tlr4: central component of the sole mammalian LPS sensor
Q26866038To drive or be driven: the path of a mouse model of recurrent pregnancy loss
Q33919388Tolerance and hematopoietic stem cell transplantation 50 years after Burnet's theory
Q70823350Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
Q24300611Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA
Q34537817Toll receptors: a central element in innate immune responses
Q34026903Toll signaling: the enigma variations
Q55033421Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
Q38928359Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).
Q51692419Toll-like receptor-4 is involved in eliciting an LPS-induced oxidative burst in neutrophils.
Q29615458Toll-like receptors and innate immunity
Q34296477Toll-like receptors and innate immunity.
Q34932177Toll-like receptors as potential therapeutic targets for multiple diseases
Q37779740Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application
Q53687316Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.
Q27486231Toll-like receptors regulation of viral infection and disease☆
Q38140711Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans
Q37705431Towards a liquid self: how time, geography, and life experiences reshape the biological identity
Q51898265Towards understanding the immune system.
Q35090683Trauma is danger
Q37223201Treatment with recombinant human bone morphogenetic protein 7 leads to a transient induction of neutralizing autoantibodies in a subset of patients.
Q37867107Trends in vaccine adjuvants.
Q34626956Tumor antigen-dependent and tumor antigen-independent activation of antitumor activity in T cells by a bispecific antibody-modified tumor vaccine
Q36171257Tweaking Innate Immunity: the Promise of Innate Immunologicals As Anti-infectives
Q41472307Unravelling the mast cell dilemma: culprit or victim of its generosity?
Q35646594Usefulness of the Nonself-Self Algorithm of HLA Epitope Immunogenicity in the Specificity Analysis of Monospecific Antibodies Induced during Pregnancy
Q37119041Using innate immunity to characterize the host response to microbial invasion in severe sepsis
Q30901141V genes in primates from whole genome sequencing data.
Q35192218Vaccine adjuvant technology: from mechanistic concepts to practical applications
Q36959938Vaccine immunopotentiators of the future
Q36638343Venom of Parasitoid Pteromalus puparum Impairs Host Humoral Antimicrobial Activity by Decreasing Host Cecropin and Lysozyme Gene Expression
Q34064782Venom of parasitoid, Pteromalus puparum, suppresses host, Pieris rapae, immune promotion by decreasing host C-type lectin gene expression
Q84926012What is so special about thinking; after all, we all do it!
Q34627005What is the 'true' function of skin?
Q37227956What roles do regulatory T cells play in the control of the adaptive immune response?
Q36762514When three is not a crowd: a Crossregulation model of the dynamics and repertoire selection of regulatory CD4+ T cells.
Q33544032Why are dendritic cells central to cancer immunotherapy?
Q47975133Xenogeneic skin graft rejection in M‐CSF/macrophage deficient osteopetrotic mice
Q57258278poly(I:C) and LPS induce distinct IRF3 and NF-κB signaling during type-I IFN and TNF responses in human macrophages
Q58385453γδ T cells provide a breath of fresh air for asthma research

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