Charles Janeway

American immunologist (1943–2003)

DBpedia resource is: http://dbpedia.org/resource/Charles_Janeway

Abstract is: Charles Alderson Janeway, Jr. (1943–2003) was a noted immunologist who helped create the modern field of innate immunity. A member of the National Academy of Sciences, he held a faculty position at Yale University's Medical School and was an HHMI Investigator.

Born 1943-02-05 in Boston (Q100)
Died 2003-04-12

Charles Janeway is …
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humanQ5

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P268Bibliothèque nationale de France ID135174264
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P5380National Academy of Sciences member ID3009515
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P11686University of Barcelona authority ID981058519678406706
P214VIAF ID100308245
P10832WorldCat Entities IDE39PBJq74TkKvbyQWrDdVQcQMP

P166award receivedGerman Immunology PrizeQ790636
William B. Coley AwardQ918979
American Association of Immunologists Lifetime Achievement AwardQ56667085
P27country of citizenshipUnited States of AmericaQ30
P1343described by sourceMedvikQ99413897
P69educated atHarvard Medical SchoolQ49121
Phillips Exeter AcademyQ1426464
P108employerYale UniversityQ49112
P734family nameJanewayQ37450939
JanewayQ37450939
JanewayQ37450939
P22fatherCharles Alderson JanewayQ5075026
P101field of workimmunologyQ101929
P8017generational suffixL252247-F2
P735given nameCharlesQ2958359
CharlesQ2958359
P1412languages spoken, written or signedEnglishQ1860
P463member ofNational Academy of SciencesQ270794
P106occupationresearcherQ1650915
university teacherQ1622272
immunologistQ12119633
P21sex or gendermaleQ6581097

Reverse relations

author (P50)
Q35080761A B-cell receptor-specific selection step governs immature to mature B cell differentiation
Q74279758A NK1.1+ thymocyte-derived TCR beta-chain transgene promotes positive selection of thymic NK1.1+ alpha beta T cells
Q72841442A cloned, antigen-specific, Ia-restricted Lyt-1+,2- T cell with suppressive activity
Q72906752A column method for deoxygenating human hemoglobin
Q28131769A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Q52184759A molecular map of T cell development.
Q41256327A novel MHC class II epitope expressed in thymic medulla but not cortex
Q77552459A novel method for concurrent visualization of immunostain under light and electron microscopy in pancreatic islets
Q44355383A pool of central memory-like CD4 T cells contains effector memory precursors
Q59057981A primitive immune system
Q73630433A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection
Q41734424A simple method for the radioactive iodination of CD4 molecules
Q74545036A tale of two T cells
Q48735173A trip through my life with an immunological theme
Q70039557Ability of fixed B-lymphoma cells to present foreign protein antigen fragments and allogenic MHC molecules to a cloned helper-T-cell line
Q72607766Absence of an antigen-specific helper T cell required for the expression of the Tn 15 idiotype in mice treated with anti-μ antibody
Q58991614Accessories or coreceptors?
Q46592828Activity of migration inhibitory factor in the absence of antigen
Q71159158Advances in paediatrics
Q58869466Affinity-purified antigen-specific products produced by T cells share epitopes recognized by heterologous antisera raised against several different antigen-specific products from T cells
Q73002892Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites
Q36368633Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.
Q34982958Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection
Q67490020An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain
Q66878910An analysis of the defective response of CBA/N mice to T-dependent antigens
Q41729786An ancient system of host defense
Q59081580An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes
Q67244072An external stimulus that mimics Mls locus responses
Q40890469An islet-specific CD8+ T cell hybridoma generated from non-obese diabetic mice recognizes insulin as an autoantigen
Q34025467Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus
Q72056665Anti-CD45 augments response of a Th2 clone to TCR cross-linking
Q57135580Antibody-activated immunoregulatory T cells are defective in B cell deprived mice
Q58990592Antigen presentation by B cells
Q70237087Antigen-dependent selection of B lymphoma cells varying in Ia density by cloned antigen-specific L3T4a+ T cells: a possible in vitro model for B cell adaptive differentiation
Q28274344Approaching the asymptote? Evolution and revolution in immunology
Q72243537Are All Baby Foods Special Dietary Foods?
Q40903645Are there cellular superantigens?
Q43990281Asymmetry in the recognition of antigen: self class II MHC and non-self class II MHC molecules by the same T-cell receptor
Q35595889Autocrine growth inhibition of a cloned line of helper T cells
Q57137913B cell-deprived mice lack functional expression of certain T suppressor cell subsets
Q41746420Bacterial proteins that mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC.
Q72114819Beneficial autoimmunity?
Q79880097Blood and Blood Derivatives-A New Public Health Field
Q36348048Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells
Q41440548Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity
Q67854327Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c
Q38186373CD4+ T cells: specificity and function.
Q73719540CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis
Q36366075CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
Q35159175CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. VII. CONCENTRATED HUMAN SERUM ALBUMIN.
Q40974770CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XII. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PREVENTION AND ATTENUATION OF MEASLES.
Q35388074CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXVI. INACTIVATION OF THE VIRUS OF HOMOLOGOUS SERUM HEPATITIS IN SOLUTIONS OF NORMAL HUMAN SERUM ALBUMIN BY MEANS OF HEAT.
Q33366765CIITA activates the expression of MHC class II genes in mouse T cells
Q52229971Cell cooperation during in vivo anti-hapten antibody responses. V. Two synergistic Ly-1+23- helper T cells with distinctive specificities.
Q52229993Cell cooperation during in vivo anti-hapten antibody responses. VI. Evidence for an allogeneic effect replacing one of two helper T cells.
Q70011292Cell interactions in the immune system: the role of self recognition in the targeting of nonspecific effector molecules by helper T cells
Q70377367Cell surface expression and alloantigenic function of a human class I MHC heavy chain gene (HLA-B7) in transgenic mice
Q37599148Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.
Q66875588Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response
Q66875591Cellular cooperation during in vivo anti-hapten antibody responses. II. The effect of in vivo and in vitro x-irradiation on T and B cells
Q66875594Cellular cooperation during in vivo anti-hapten antibody responses. III. The helper cell activity of activated thymocytes, of spleen cells treated with anti-theta serum, and of spleen cells from anti-thymocyte serum-treated or adult thymectomized do
Q71785417Characterization of H4: a mouse T lymphocyte activation molecule functionally associated with the CD3/T cell receptor
Q31406838Characterization of a novel human surface molecule selectively expressed by mature thymocytes, activated T cells and subsets of T cell lymphomas
Q36263328Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors
Q54217791Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognatevs. noncognate interactions in cytolysis
Q36365469Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophages
Q80505309Co-receptor selection: chance or necessity?
Q28587141Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen
Q34340219Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells
Q60962704Continuity and Change
Q44493498Control of T cell responses to staphylococcal enterotoxins by stimulator cell MHC class II polymorphism.
Q59067228Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted
Q73065666Cross-antagonism of a T cell clone expressing two distinct T cell receptors
Q38787617Cross-linking and conformational change in T-cell receptors: role in activation and in repertoire selection
Q34396895Danger - pathogen on the premises! Immunological tolerance
Q72672701Deciphering the mysteries of RNA-containing lupus antigens
Q29618448Decoding the patterns of self and nonself by the innate immune system
Q70387554Defective antigen presentation in chronically protein-deprived mice
Q77879066Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition
Q42008648Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice
Q54446860Diagnosis and treatment of antibody deficiency syndromes.
Q71829171Differences in the avidity of TCR interactions with a superantigenic ligand affect negative selection but do not allow positive selection
Q42812488Different phenotypic variants of the mouse B cell tumor A20/2J are selected by antigen- and mitogen-triggered cytotoxicity of L3T4-positive, I-A-restricted T cell clones
Q36366515Different superantigens interact with distinct sites in the Vbeta domain of a single T cell receptor
Q73822011Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment
Q41384220Differential effects of antibodies to Lyt-2 and L3T4 on cytolysis by cloned, Ia-restricted T cells expressing both proteins.
Q71629738Differential expression of Ia glycoprotein complexes in F1 hybrid mice detected with alloreactive cloned T cell lines
Q30966114Differential sensitivity to mutations in a single peptide by two TCRs having identical beta-chains and closely related alpha-chains
Q36351526Direct interactions between B and T lymphocytes bearing complementary receptors
Q71702645Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV
Q70072984Direct receptor:receptor interactions between T and B lymphocytes: idiotypic restriction in the antibody response to a cloned helper T cell receptor
Q38521828Distinctive immunological properties of cultured murine thymic epithelial cells
Q34291745Diversity in T-cell receptor gamma gene usage in intestinal epithelium
Q37113954Diversity, Development, Ligands, and Probable Functions of γδ T Cells
Q38263019Diversity, development, ligands, and probable functions of gamma delta T cells.
Q72219989Do B cells drive the diversification of immune responses?
Q70058118Do suppressor T cells exist? A reply
Q34111446Dual receptor T cells extend the immune repertoire for foreign antigens.
Q22010492ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
Q72798024Efficiency of antigen presentation differs in mice differing at the Mls locus
Q40771367Elevated temperature regulates tumor necrosis factor-mediated immune killing
Q48194701Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis.
Q59046883Epithelial homing of γδ T cells?
Q59049347Erratum: An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes
Q40951076Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis
Q58974599Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor
Q35058262Evidence for an immunoglobulin-dependent antigen-specific helper T cell
Q67898914Exclusive Expression of MHC Class II Proteins on CD45+ Cells in Pancreatic Islets of NOD Mice
Q36400766Exogenously provided peptides of a self-antigen can be processed into forms that are recognized by self-T cells
Q34411828Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
Q41120203Experimental malaria in the CBA/N mouse
Q36343940Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. I. Mapping of genes for Id-460 expression to the variable region of immunoglobulin heavy-chain locus and to the variable region of immunoglobulin kappa-light-ch
Q36345891Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. II. Transient idiotypic dominance
Q36345896Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. III. Detection of Id-460 in normal serum that does not bind dinitrophenyl
Q71679204Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
Q73703190Expression of the novel T cell activation molecule hpH4 in HIV-infected patients: correlation with disease status
Q44169854Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism.
Q41603286Extensive CD4 cross-linking inhibits T cell activation by anti-receptor antibody but not by antigen
Q53723181Family Medicine — Fad or for Real?
Q59061027Frontiers of the immune system
Q72095821Functional activities of antibodies against brain-associated T cell antigens. I. Induction of T cell proliferation
Q73709090Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice
Q39729177Functional heterogeneity among the T-derived lymphocytes of the mouse. IV. Nature of spontaneously induced suppressor cells
Q44187779Further observations on the Swiss type of agammaglobulinemia (alymphocytosis). The effect of syngeneic bone-marrow cells
Q68443450Gamma delta T cells: research on the frontlines of defence
Q63363246Gamma delta T-cell lines isolated from intestinal epithelium respond to a B-cell lymphoma
Q44917921Generation, propagation, and variation in cloned, antigen-specific, Ia-restricted cytolytic T-cell lines
Q69813051Goals and constraints in the education of physicians
Q72820239Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2
Q36260793HISTOLOGICAL AND SEROLOGICAL SEQUENCES IN EXPERIMENTAL HYPERSENSITIVITY.
Q47941090Hapten-specific augmentation of the anti-idiotype antibody response to hapten-myeloma protein conjugates in mice
Q28508401Heat-stable antigen is a costimulatory molecule for CD4 T cell growth
Q67241059Helper T Cells Specific for Protein Antigens: Role of Self Major Histocompatibility Complex and Immunoglobulin Gene Products
Q40711763Helper T cell interactions.
Q71687834High density insulin receptor-positive T lymphocytes from nonobese diabetic mice transfer insulitis and diabetes
Q80506072High fives or hand clasps?
Q67885876High levels of IL-2 alter signal transduction in cloned IL-4-producing CD4 T cells
Q40102550How T lymphocytes recognize antigen
Q74054495How does the immune system distinguish self from nonself?
Q34439868How the immune system protects the host from infection
Q40766883How the immune system recognizes invaders.
Q34272671How the immune system works to protect the host from infection: a personal view
Q58999702Human T-cell receptor expression
Q24302640IRAK-M is a negative regulator of Toll-like receptor signaling
Q30763625Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
Q40097641Idiotypes, T-Cell Receptors, and T-B Cooperation
Q48294358IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection
Q63363260Immune recognition and effector function in subsets of CD4 T cells
Q36346112Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex
Q36346118Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function
Q39448586Immune responses of BALB/c mice to the idiotype of T15 and of other myeloma proteins of BALB/c origin: implications for an immune network and antibody multispecificity
Q54421792Immune serum from mice contact-sensitized with picryl chloride contains an antigen-specific T cell factor that transfers immediate cutaneous reactivity.
Q36466805Immunochemical identification of cytophilic antibody in human lymphocytes
Q55059065Immunogenicity signals 1,2,3 ... and 0.
Q93703899Immunoglobulin determinants on the lymphocytes of normal rabbits. 3. As4 and As6 determinants on individual lymphocytes and the concept of allelic exclusion
Q54621020Immunoglobulin determinants on the lymphocytes of normal rabbits. I. Demonstration by the mixed antiglobulin reaction of determinants recognized by anti-gamma, anti-mu, anti-Fab and anti-allotype sera, anti-As4 and anti-As6.
Q52272335Immunologic amnesia. Study of an 11-year-old girl with recurrent severe infections associated with dysgammaglobulinemia, lymphopenia and lymphocytotoxic antibody, resulting in loss of immunologic memory.
Q73009596Immunology at Yale
Q33824735Immunology: improving on nature in the twenty-first century
Q54379846Immunoregulatory role of Ig isotypes. I. Induction of contrasuppressor T cells for contact sensitivity responses by antibodies of the IgM, IgG1, and IgG3 isotypes.
Q57136187Immunoregulatory role of Ig isotypes. II. Activation of cells that block induction of contact sensitivity responses by antibodies of IgG2a and IgG2b isotypes
Q59047650Immunotherapy by peptides?
Q34203686Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome).
Q71257547In vitro cultivation of nonlymphoid thymic cells: morphological and immunological characterization
Q56909790Induction of B cell costimulatory function by recombinant murine CD40 ligand
Q36361095Induction of autoreactive B cells allows priming of autoreactive T cells
Q70503024Induction of receptors for interleukin 2 requires T cell Ag:Ia receptor crosslinking and interleukin 1
Q68800390Influence of immunoglobulin-dependent T cells on antibody class switching
Q69736120Inhibition of the responses of a cloned CD4+ T cell line to different class II major histocompatibility complex ligands by anti-CD4 and by anti-receptor Fab fragments are directly related
Q34170877Innate immune induction of the adaptive immune response
Q27860721Innate immune recognition
Q77502590Innate immune recognition and control of adaptive immune responses
Q28138782Innate immune recognition: mechanisms and pathways
Q74520742Innate immunity
Q41353080Innate immunity: impact on the adaptive immune response
Q29614428Innate immunity: the virtues of a nonclonal system of recognition
Q33814945Insulin-dependent diabetes mellitus and its animal models.
Q36354156Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance
Q59065280Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells
Q53875283Intravenous dissociated gamma globulin in control of hypogammaglobulinemia.
Q47967599Introduction: T-cell:B-cell interaction.
Q95440614Introduction: the role of innate immunity in the adaptive immune response
Q40888700Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003.
Q70363593Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen
Q52078248Isoform-specific associations of CD45 with accessory molecules in human T lymphocytes
Q39407717Isolation of antigen-binding cells from unprimed mice. II. Evidence for monospecificity of antigen-binding cells
Q80506162It is easier for a camel to pass the needle's eye
Q41010582John Howland Award Acceptance Address: From the American Pediatric Society, April 26,1978, New York, New York
Q68442292Ligand thresholds at different stages of T cell development
Q40543526Ligands for the T-cell receptor: hard times for avidity models
Q39548662Lipid-modified antigens. I. Specificity of guinea pig T lymphocyte responses and I-region restriction
Q73294953Lipoproteins take their toll on the host
Q36367622Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells
Q44975100Low doses of interleukin 2 induce bystander cell lysis by antigen-specific CD4+ inflammatory T cell clones in short-term assay
Q72870993Lymphocyte activation and effector functions. Editorial overview. The role of cell surface molecules
Q69880446Lymphocytes: the Third World
Q34188470MHC and T cell development
Q72681437MHC recognition by clones of Mls specific T-lymphocytes
Q35053402MHC specificity of iIELs
Q59073029MIs: makes a little sense
Q36237886Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers
Q41023334Medicine, medical science and health
Q44404224Metabolism of gamma globulin fragments in normal and agammaglobulinemic persons
Q52099252Microbial induction of co-stimulatory activity for CD4 T-cell growth.
Q67295598Modes of cell:cell communication in the immune system
Q52105374Molecular associations on the T cell surface correlate with immunological memory.
Q48367849Molecular characterization of antibodies bearing Id-460. I. The structure of two highly homologous VH genes used to produce idiotype positive immunoglobulins
Q36351229Molecular characterization of antibodies bearing Id-460. II. Molecular basis for Id-460 expression
Q44662131Monoclonal Antibodies Against T Cell Receptor/CD3 Complex Induce Cell Death of Th1 Clones in the Absence of Accessory Cells
Q72802559Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells
Q69070994Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation
Q29616423Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease
Q36344030Monoclonal antibody against an Ir gene product?
Q67896783Monoclonal antibody detection of a major self peptide. MHC class II complex
Q29616209MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
Q44063328Nathalie Masse, 1919-1975
Q34067924Negative selection of thymocytes expressing the D10 TCR
Q36348440Non-dinitrophenyl-binding immunoglobulin that bears a dominant idiotype (Id460) associated with antidinitrophenyl antibody is specific for an antigen on Pasteurella pneumotropica
Q59092662On the complexity of self
Q33542318On the intrathymic intercellular transfer of self-determinants.
Q52023153On the self-referential nature of naive MHC class II-restricted T cells.
Q38460224On the semantics of immune recognition
Q33624770Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells
Q40429223PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae
Q33930556Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide
Q70108359Passive immunization against chicken pox
Q72881461Pediatric education in the United States
Q48423819Pediatrics and the adolescent. Presentation of the C. Anderson Aldrich Award to J. Roswell Gallagher
Q73287492Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR
Q59028086Peptides bound to MHC
Q28144345Phylogenetic perspectives in innate immunity
Q33854139Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies
Q41640150Physical association of CD4 with the T cell receptor
Q47847510Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627.
Q34378927Pillars article: approaching the asymptote? Evolution and revolution in immunology. Cold spring harb symp quant biol. 1989. 54: 1-13.
Q47861987Polymorphism of the mouse T-cell receptor AV20S1 gene
Q48423537Presentation of the Howland Award to Louis K. Diamond
Q48176320Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis.
Q34749528Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response.
Q71739896Prevention of Posttransfusion Hepatitis
Q41758960Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes
Q39877080Progress in immunology. Syndromes of diminished resistance to infection
Q36368555Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes
Q38257795Quantitative variation in la antigen expression plays a central role in immune regulation
Q24292468RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Q44044768Receptor-directed focusing of lymphokine release by helper T cells
Q34294731Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors.
Q44122425Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor
Q35082019Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes
Q40938432Recurrent infections, episodic lymphopenia and impaired cellular immunity
Q70490926Regulation of the immune response through idiotypic interactions
Q57134954Regulatory responses in contact sensitivity: Afferent suppressor T cells inhibit the activation of efferent suppressor T cells
Q52539853Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice.
Q52457524Reminiscences of late Professor S.T. Achar
Q48913563Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
Q41207462Responses of T cells to ligands for the T-cell receptor
Q40808115Rules for peptide presentation by MHC class II molecules
Q40982703STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation.
Q40972958STUDIES ON INFECTIOUS MONONUCLEOSIS. II. THE RELATIONSHIP OF THE ORGANISMS OF THE GENUS LISTERELLA TO THE DISEASE, AS STUDIED BY THE AGGLUTINATION REACTION.
Q35157374STUDIES ON THE PLASMA PROTEINS. V. THE EFFECT OF CONCENTRATED SOLUTIONS OF HUMAN AND BOVINE SERUM ALBUMIN ON BLOOD VOLUME AFTER ACUTE BLOOD LOSS IN MAN.
Q71767844Screening for inherited diseases
Q42261752Selected populations of alloreactive T cells contain helper T cells but lack ThId, an antigen-specific helper T cell required for dominant production of the T15 idiotype
Q37113963Selective Elements for the Vß Region of the T Cell Receptor: MIs and the Bacterial Toxic Mitogens
Q69377330Selective induction of growth factor production and growth factor receptor expression by different signals to a single T cell
Q72813834Self la-recognizing T cells undergo an ordered series of interactions with ia-bearing substrate cells of defined function during their development: A model
Q72303912Self peptides isolated from MHC glycoproteins of non-obese diabetic mice
Q37976429Self superantigens?
Q36046613Self-defense: the fruit fly style
Q52943711Self-recognition and the biased mature repertoire in TCR beta transgenic mice: the exception that supports the rule.
Q28303686Sequence analysis of peptides bound to MHC class II molecules
Q41282431Signaling by a new anti-Thy 1 monoclonal antibody inhibits T cell proliferation and interferes with T-cell-mediated induction of costimulatory molecule B7-2.
Q40620206Signals and signs for lymphocyte responses
Q72279459Some shortcomings of medical education in a free society
Q66887226Specific and Nonspecific Cooperation Between M-Locus-Incompatible T and B Cells During Adoptive Anti-Hapten Antibody Responses in Mice
Q39802093Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells
Q44385574Specificity and function of T cells bearing gamma delta receptors
Q41492321Stimulator cell type influences the response of T cells to staphylococcal enterotoxins
Q40789973Studies on naturally processed peptides associated with MHC class II molecules.
Q54662921Studies with intravenous gamma globulin.
Q36285397Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides
Q72332839Superantigen-like properties of an antibody bispecific for MHC class II molecules and the V beta domain of the T cell antigen receptor
Q39499469Suppressor T cells and immunoregulation: an overview
Q36361169Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
Q72027965Synthetic antigens composed exclusively of L- or D- amino acids. II. Effect of optical configuration on the metabolism and fate of synthetic polypeptide antigens in mice
Q71240187Synthetic antigens composed exclusively of L- or D-amino acids. 3. Anamnestic response to a synthetic polypeptide composed exclusively of D-amino acids
Q72226911Synthetic antigens composed exclusively of L- or D-amino acids. I. Effect of optical configuration on the immunogenicity of synthetic polypeptides in mice
Q67540230T and B cell receptors discriminate major histocompatibility complex class II conformations influenced by the invariant chain
Q48819718T cell adhesion to endothelial cells and extracellular matrix is modulated upon transendothelial cell migration
Q47989582T cell-mediated immunity in malaria. I. The Ly phenotype of T cells mediating resistance to Plasmodium yoelii.
Q33864874T cells from epicutaneously immunized mice are prone to T cell receptor revision
Q40676778T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten
Q34756338T cells with two functional antigen-specific receptors
Q39816014T lymphocyte responses to Mls locus antigens involve recognition of H-2 I region gene products
Q47743587T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted
Q72082792T-Cell receptor idiotypes
Q33632307T-cell development: a role for self-peptides in positive selection
Q66875670T-cell populations with different functions
Q41441623T-cell receptors: is the repertoire inherently MHC-specific?
Q85701076T-cell regulation of IgA responses
Q38249158T-cell responses to Mls and to bacterial proteins that mimic its behavior
Q72873502TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective
Q41537404TCR-CD4 and TCR-TCR interactions as distinctive mechanisms for the induction of increased intracellular calcium in T-cell signalling
Q45228667The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.
Q71155887The Child With Recurrent Infections
Q36348755The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic Ia or antigen and self-Ia
Q36060959The Immunological System of the Child: Part I: Development of Immunity in the Child
Q36060950The Immunological System of the Child: Part II: Immunological Deficiency States
Q43837212The L3T4 molecule is part of the helper T-cell antigen/Ia recognition complex
Q67256810The Mls locus: new clues to a lingering mystery
Q41287605The Mls locus: past, present and future
Q34170758The PTK-STAT signaling pathway has essential roles in T-cell activation in response to antigen stimulation
Q72595917The Structure and Function of T Cell Receptor Complexes
Q35876939The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation
Q47234164The alpha- and beta-subunits of a murine T cell antigen/Ia receptor have a molecular weight of 31,000 in the absence of N-linked glycosylation
Q41251975The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized.
Q80505725The case of the missing CD4s
Q72368991The child with frequent infections: diagnostic considerations
Q36680146The co-receptor function of CD4.
Q38680368The co-receptor function of murine CD4.
Q50255246The discovery of T cell help for B cell antibody formation: a perspective from the 30th anniversary of this discovery
Q72742910The expression of I-Ed molecules in F1 hybrid mice detected with antigen-specific, I-Ed-restricted cloned T-cell lines
Q72435840The fate of a D-amino acid polypeptide [p(D-Tyr, D-Glu, D-Ala), 247] in newborn and adult mice: relationship to the induction of tolerance
Q40038188The gamma globulins. 3. The antibody deficiency syndromes
Q71191861The gamma globulins. 3. The antibody deficiency syndromes
Q39876099The gamma globulins. II. Hypergammaglobulinemia
Q70067775The gamma globulins. II. Hypergammaglobulinemia
Q39876085The gamma globulins. IV. Therapeutic uses of gamma globulin
Q85699855The immune destruction of pancreatic β cells
Q36774100The immune system evolved to discriminate infectious nonself from noninfectious self
Q41279371The immunobiology of T cell responses to Mls-locus-disparate stimulator cells. II. Effects of Mls-locus-disparate stimulator cells on cloned, protein antigen-specific, Ia-restricted T cell lines.
Q69980480The immunobiology of T cell responses to Mls-locus-disparate stimulator cells. III. Helper and cytolytic functions of cloned, Mls-reactive T cell lines
Q70060738The immunobiology of the T cell response to Mls locus disparate stimulator cells
Q65001745The immunobiology of the T cell response to Mls-locus-disparate stimulator cells. I. Unidirectionality, new strain combinations, and the role of Ia antigens.
Q44187650The immunosuppressive agent 15-deoxyspergualin functions by inhibiting cell cycle progression and cytokine production following naive T cell activation
Q73838326The imprint of intrathymic self-peptides on the mature T cell receptor repertoire
Q41356845The influence of valence on the functional activities of monoclonal anti-L3T4 antibodies. Discrimination of signaling from other effects
Q47975958The mechanism of a hapten-specific helper effect in mice
Q36362806The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells
Q41085131The orientation of a T cell receptor to its MHC class II:peptide ligands
Q34140758The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.
Q35999275The priming of helper T cells.
Q43546974The response in vitro of human lymphocytes to phytohemagglutinin and to antigens after fractionation on discontinuous density gradients of albumin
Q41628525The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse.
Q38706502The role of CD4 in T-cell activation: accessory molecule or co-receptor?
Q33767934The role of CD4 vs. CD8 T cells in IDDM.
Q73205341The role of Fas in autoimmune diabetes
Q68856856The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal
Q57137515The role of immunoglobulin and B cells in T cell ontogeny and repertoire formation--a commentary
Q36401103The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice
Q33735987The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory
Q41359310The role of the murine L3T4 molecule in T cell activation: differential effects of anti-L3T4 on activation by monoclonal anti-receptor antibodies
Q41066379The role of thymus-derived lymphocytes in an antibody-mediated hapten-specific helper effect
Q85699573The selection of self-MHC recognizing T lymphocytes: a role for idiotypes?
Q74321445The source of early IFN-gamma that plays a role in Th1 priming
Q37395408The specific direct interaction of helper T cells and antigen-presenting B cells
Q28592120The specificity and orientation of a TCR to its peptide-MHC class II ligands
Q28317910The specificity of T lymphocyte responses to chemically defined antigens
Q36360089The specificity of cellular immune responses II. The structure of antigenic determinants leading to T-lymphocyte stimulation
Q36360200The specificity of cellular immune responses in guinea pigs. I. T cells specific for 2,4-dinitrophenyl-o-tyrosyl residues
Q36360077The specificity of cellular immune responses in guinea pigs. III. The precision of antigen recognition by T lymphocytes
Q68813751The targeting of effector molecules in the immune system
Q67702854The use of the polymerase chain reaction to map CD4+ T cell epitopes
Q85702147Through a glass, darkly …
Q40612322Thymic selection: two pathways to life and two to death
Q33656002Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice
Q80506335To thine own self be true...
Q33713298Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis
Q36350890Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity.
Q41063958Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression
Q41599064Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs
Q39414474Two Different VH Gene Products Make Up the T-Cell Receptors
Q36343852Two distinct antigen-specific suppressor factors induced by the oral administration of antigen
Q40770827Type 1 diabetes mellitus: an imbalance between effector and regulatory T cells?
Q40015489Unnecessary and preventable hospitalizations: report on an internal audit
Q42080455Use of Concentrated Human Serum gamma-Globulin in the Prevention and Attenuation of Measles
Q37605603Use of anti-idiotype immunosorbents to isolate circulating antigen-specific T cell-derived molecules from hyperimmune sera
Q41695997V beta selective elements: self and non-self
Q58662373Variability of invariant mouse CD3ε chains detected by anti-CD3 antibodies
Q70072978Varieties of idiotype-specific helper T cells--a commentary
Q44176131graal: a Drosophila gene coding for several mosaic serine proteases

main subject (P921)
Q48687110A goodbye to Charlie Janeway: Charles A. Janeway Jr (1943-2003).
Q60962705Charles A Janeway Jr
Q50426900Charles Janeway, Jr.
Q48675649In memoriam. Charles A. Janeway, Jr. February 5, 1943-April 12, 2003.
Q30336203Obituary. Charles A. Janeway, Jr. (1943-2003).
Q30332847Obituary: Charles A. Janeway Jr (1943-2003).
Q45778904Recollections of Charlie: Dr. Charles Alderson Janeway, Jr. (1943-2003).
Q24611211Toward a modern synthesis of immunity: Charles A. Janeway Jr. and the immunologist's dirty little secret

Q5075026Charles Alderson JanewaychildP40

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