Serum level of hepatocyte growth factor is a novel marker of predicting the outcome and resistance to the treatment with trastuzumab in HER2-positive patients with metastatic gastric cancer

scientific article published on 24 December 2015

Serum level of hepatocyte growth factor is a novel marker of predicting the outcome and resistance to the treatment with trastuzumab in HER2-positive patients with metastatic gastric cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.6753
P932PMC publication ID4826254
P698PubMed publication ID26716644
P5875ResearchGate publication ID288830539

P2093author name stringKen Kato
Yasuhide Yamada
Hirokazu Taniguchi
Naoki Takahashi
Tetsuya Hamaguchi
Yasuhiro Shimada
Koh Furuta
Satoru Iwasa
Yusuke Sasaki
Yoshitaka Honma
Hirokazu Shoji
Atsuo Takashima
Natsuko Okita
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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Evaluation of HER2 protein expression in gastric carcinomas: comparative analysis of 1,414 cases of whole-tissue sections and 595 cases of tissue microarraysQ83789922
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: an open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2 studyQ33416122
Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancerQ33682988
HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker developmentQ33917507
High circulating hepatocyte growth factor levels associate with epithelial to mesenchymal transition and poor outcome in small cell lung cancer patientsQ34221586
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunitiesQ34399306
HGF rescues colorectal cancer cells from EGFR inhibition via MET activationQ34550898
Treatment options in patients with metastatic gastric cancer: current status and future perspectivesQ34661367
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinibQ35666332
MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcomeQ36089948
Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancerQ36184256
MET amplification as a potential therapeutic target in gastric cancer.Q36984821
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Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancerQ38980193
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MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cellsQ39413378
Co-expression of hepatocyte growth factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte growth factor/c-Met signaling in gastric cancerQ39499360
Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cellsQ40006240
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cellsQ40344963
HGF converts ErbB2/Neu epithelial morphogenesis to cell invasionQ40490783
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HGF-MET as a breast cancer biomarkerQ43228470
Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cellsQ43539817
Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancerQ44764084
Prognostic significance of targetable angiogenic and growth factors in patients undergoing resection for gastric and gastroesophageal junction cancersQ46068781
Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32.Q46458791
Efficacy of S-1 plus cisplatin combination chemotherapy in patients with HER2-positive advanced gastric cancerQ46839142
HER2-positive patients receiving trastuzumab treatment have a comparable prognosis with HER2-negative advanced gastric cancer patients: a prospective cohort observation.Q50761028
HER2 status in gastric cancers: a retrospective analysis from four Chinese representative clinical centers and assessment of its prognostic significance.Q50889414
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Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma.Q54218339
Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer.Q54341358
Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome.Q54578578
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P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
P304page(s)4925-4938
P577publication date2015-12-24
P1433published inOncotargetQ1573155
P1476titleSerum level of hepatocyte growth factor is a novel marker of predicting the outcome and resistance to the treatment with trastuzumab in HER2-positive patients with metastatic gastric cancer
P478volume7

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cites work (P2860)
Q57176090Biomarkers of gastric cancer: Current topics and future perspective
Q89842618Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer
Q42700876Clinical impact of high serum hepatocyte growth factor in advanced non-small cell lung cancer
Q89687522Clinical significance of various growth factors in patients with different gastric neoplasms
Q47932548Depth of response predicts the clinical outcome of advanced HER2-positive gastric cancer to trastuzumab-based first-line chemotherapy
Q37735624Hepatocyte growth factor/MET in cancer progression and biomarker discovery
Q89795555Human Epidermal Growth Factor Receptor 2 (HER2) in Advanced Gastric Cancer: Current Knowledge and Future Perspectives
Q37745875Identification of serum proteins and multivariate models for diagnosis and therapeutic monitoring of lung cancer
Q52657273The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition.

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