Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae

scientific article published on 15 March 2013

Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1534/GENETICS.113.149708
P8608Fatcat IDrelease_vtw7zwj3ube77av6uyqh2y5sjq
P932PMC publication ID3632477
P698PubMed publication ID23502676

P2093author name stringGörkem Garipler
Cory D Dunn
P2860cites workLocalization of polyphosphate in vacuoles of Saccharomyces cerevisiaeQ40886464
Genetic and biochemical basis for viability of yeast lacking mitochondrial genomes.Q41844258
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeastQ41970961
Compartment acidification is required for efficient sorting of proteins to the vacuole in Saccharomyces cerevisiaeQ41999129
Cytosolic localization of acetohydroxyacid synthase Ilv2 and its impact on diacetyl formation during beer fermentationQ42119460
Mutations in the mitochondrial ATP synthase gamma subunit suppress a slow-growth phenotype of yme1 yeast lacking mitochondrial DNA.Q42921948
Plasma membrane localization of Ras requires class C Vps proteins and functional mitochondria in Saccharomyces cerevisiae.Q42942201
Assessment of mitochondrial membrane potential in proximal tubules after hypoxia-reoxygenationQ45206203
The Yeast Vacuolar Membrane ProteomeQ57016848
The role of adenine nucleotide translocation in the energization of the inner membrane of mitochondria isolated from rho + and rho degree strains of Saccharomyces cerevisiaeQ69921208
Site-directed mutagenesis of the yeast V-ATPase B subunit (Vma2p)Q70915145
Requirement of a Membrane Potential for the Posttranslational Transfer of Proteins into MitochondsriaQ72762095
Import of proteins into mitochondria. Yeast cells grown in the presence of carbonyl cyanide m-chlorophenylhydrazone accumulate massive amounts of some mitochondrial precursor polypeptidesQ72959521
Alternative mechanisms of vacuolar acidification in H(+)-ATPase-deficient yeastQ73279999
The absence of the mitochondrial ATP synthase delta subunit promotes a slow growth phenotype of rho- yeast cells by a lack of assembly of the catalytic sector F1Q73414419
INDUCTION OF PETITE MUTATION AND INHIBITION OF SYNTHESIS OF RESPIRATORY ENZYMES IN VARIOUS YEASTSQ76845728
Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cellsQ77305182
Kinetic properties of F1-ATPase influence the ability of yeasts to grow in anoxia or absence of mtDNAQ81110513
Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae.Q24814055
Characterization of yeast V-ATPase mutants lacking Vph1p or Stv1p and the effect on endocytosisQ27929778
Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiaeQ27931316
Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complexQ27933251
Role of vacuolar acidification in protein sorting and zymogen activation: a genetic analysis of the yeast vacuolar proton-translocating ATPaseQ27933484
Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genesQ27934841
Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiaeQ27935307
Saccharomyces cerevisiae lacking Btn1p modulate vacuolar ATPase activity to regulate pH imbalance in the vacuoleQ27936371
A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complexQ27937167
New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysisQ27937759
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolasesQ27937990
Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1pQ27940327
VMA13 encodes a 54-kDa vacuolar H(+)-ATPase subunit required for activity but not assembly of the enzyme complex in Saccharomyces cerevisiaeQ28261416
DiOC6 staining reveals organelle structure and dynamics in living yeast cellsQ28298131
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian agingQ29616056
Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shapeQ29620387
Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethalityQ33568063
Vps-C complexes: gatekeepers of endolysosomal trafficQ33595195
Candida albicans PEP12 is required for biofilm integrity and in vivo virulence.Q33659023
The petite mutation in yeasts: 50 years on.Q33737165
Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiaeQ33851758
A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory functionQ33959691
Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype.Q34184643
Assay of vacuolar pH in yeast and identification of acidification-defective mutantsQ34303692
Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA.Q34618588
Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolismQ35630327
Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeastQ36761876
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defectQ37380849
Running on empty: does mitochondrial DNA mutation limit replicative lifespan in yeast?: Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiaeQ37914096
P4510describes a project that usesmitochondrial DNAQ27075
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
mitochondrial DNAQ27075
Saccharomyces cerevisiaeQ719725
P304page(s)285-290
P577publication date2013-03-15
P1433published inGeneticsQ3100575
P1476titleDefects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae
P478volume194

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cites work (P2860)
Q35683658Activation of the pleiotropic drug resistance pathway can promote mitochondrial DNA retention by fusion-defective mitochondria in Saccharomyces cerevisiae
Q37543961Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae
Q36676640Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions
Q37696384Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae
Q38196808Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension.
Q37655688Metabolic and environmental conditions determine nuclear genomic instability in budding yeast lacking mitochondrial DNA.
Q58700571Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form Trypanosoma brucei Rescues Genetic Knockdown of Mitochondrial Gene Expression
Q35890030Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA.
Q34741848The retrograde response: a conserved compensatory reaction to damage from within and from without
Q35684922Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes
Q35687142Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

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