Distinct functions of JNK and c-Jun in oxidant-induced hepatocyte death

scientific article published on October 2012

Distinct functions of JNK and c-Jun in oxidant-induced hepatocyte death is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JCB.24203
P932PMC publication ID3636504
P698PubMed publication ID22644775

P2093author name stringKun Liu
Muhammad Amir
Mark J Czaja
Enpeng Zhao
P2860cites workJNK1 but not JNK2 promotes the development of steatohepatitis in miceQ46865809
Suppression of oncogene-induced transformation by a deletion mutant of c-jun.Q53481195
Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.Q54599587
Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency statesQ67018235
Regulation of glucose utilization during the inhibition of fatty acid oxidation in rat myocytesQ72499995
Cell death in the liver-all roads lead to JNKQ79871834
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinaseQ28364720
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnoverQ28588830
Autophagy regulates lipid metabolismQ29547421
The specificities of protein kinase inhibitors: an updateQ30014834
The c-jun kinase/stress-activated pathway: regulation, function and role in human diseaseQ30500831
AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosisQ33788455
JNK regulation of hepatic manifestations of the metabolic syndromeQ34348797
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injuryQ35546843
Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-sQ35815498
Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathwayQ36889171
Temperature-sensitive adult liver cell line dependent on glucocorticoid for differentiationQ36939597
Cell signaling in oxidative stress-induced liver injuryQ36989693
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistanceQ37038490
Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2.Q37130649
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activationQ37138768
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in miceQ37376335
Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivationQ37421171
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injuryQ38291198
The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factorQ39675571
Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stressQ39688404
Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1.Q40555578
Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signalingQ40644024
NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-JunQ40742264
Hepatocytes sensitized to tumor necrosis factor-alpha cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathwaysQ40908958
Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicityQ40997966
NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis.Q41005955
Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activationQ41081201
Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentationQ41250105
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failureQ41396770
Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibitionQ41707732
Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomasQ42004966
Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell deathQ43118131
c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury.Q43294974
Dominant-negative TAK1 induces c-Myc and G(0) exit in liverQ43773093
Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cellsQ44012975
Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: implication for gene therapyQ44705077
Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytesQ44758408
Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosisQ46156894
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicityQ46679597
Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinasesQ46822908
P433issue10
P304page(s)3254-3265
P577publication date2012-10-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleDistinct functions of JNK and c-Jun in oxidant-induced hepatocyte death
P478volume113

Reverse relations

cites work (P2860)
Q45933968Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria.
Q37730848Histological and Immunohistochemical Basis of the Effect of Aminoguanidine on Renal Changes Associated with Hemorrhagic Shock in a Rat Model
Q37233445JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma
Q55407513Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.
Q50957769Non-Alcoholic Fatty Liver Disease
Q35178036P2X7 receptor as a key player in oxidative stress-driven cell fate in nonalcoholic steatohepatitis
Q34446469Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling.
Q38090568Role of oxidative stress in infectious diseases. A review.
Q35303879Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.
Q47148469The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
Q28077974Therapeutic Strategies for Oxidative Stress-Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem Cells
Q37643931c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.

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