Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1

scientific article published on December 1990

Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1 is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID248744
P698PubMed publication ID2243378

P50authorPeter BalfeQ55189943
P2093author name stringSimmonds P
Ludlam CA
Brown AJ
Bishop JO
P2860cites workGlycosylation and processing of the human immunodeficiency virus type 1 envelope proteinQ28269032
A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160Q28279759
A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changesQ28306948
Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptorQ28646793
Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.Q30355613
Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions.Q30356755
Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120Q33571605
Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzeesQ33582665
Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selectionQ33835136
Ovomucoid third domains from 100 avian species: isolation, sequences, and hypervariability of enzyme-inhibitor contact residuesQ34191965
A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitopeQ34614992
Antigenic Shift of Visna Virus in Persistently Infected SheepQ34987372
Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirusQ35616284
A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibodyQ36255699
Genomic changes associated with antigenic variation of visna virus durig persistent infectionQ36400443
Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbersQ36801268
Influence of asparagine-linked oligosaccharides on antigenicity, processing, and cell surface expression of herpes simplex virus type 1 glycoprotein D.Q36832178
HIV antigen and antibody detection: variable responses to infection in the Edinburgh haemophiliac cohortQ36895162
Role of the host immune response in selection of equine infectious anemia virus variantsQ36919966
Carbohydrates as antigenic determinants of glycoproteinsQ38179958
An improved method for directly sequencing PCR amplified material using dimethyl sulphoxideQ40521534
An improved sequencing method using SequenaseTM that is independant of template concentrationQ40547524
Specificity and function of the individual amino acids of an important determinant of human immunodeficiency virus type 1 that induces neutralizing activityQ41987108
Extensive variation of human immunodeficiency virus type-1 in vivoQ43913496
B Cell Epitope Mapping of Human Immunodeficiency Virus Envelope Glycoproteins with Long (19- to 36-residue) Synthetic PeptidesQ43950591
The polymerase chain reaction in the diagnosis of vertically transmitted HIV infectionQ44527131
Type-Restricted Neutralization of Molecular Clones of Human Immunodeficiency VirusQ45832058
Evolution of the structural proteins of human immunodeficiency virus: selective constraints on nucleotide substitutionQ45833186
Human T-lymphotropic virus type III (HTLV-III) infection in seronegative haemophiliacs after transfusion of factor VIII.Q45840233
Operational and topological analyses of antigenic sites on influenza C virus glycoprotein and their dependence on glycosylationQ45847699
Diagnosis of AIDS by using a 12-amino acid peptide representing an immunodominant epitope of the human immunodeficiency virusQ45848000
Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patientsQ45848343
Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera.Q45849314
HTLV-III seropositivity in European haemophiliacs exposed to Factor VIII concentrate imported from the USA.Q45861258
Accelerated evolution in the reactive centre regions of serine protease inhibitorsQ48348346
Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS.Q48363856
Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene.Q54381624
Human antibody response to a strain-specific HIV-1 gp120 epitope associated with cell fusion inhibition.Q55242480
Single amino-acid changes in HIV envelope affect viral tropism and receptor bindingQ59074872
Carbohydrate dramatically influences immune reactivity of antisera to viral glycoprotein antigensQ70688626
P433issue12
P407language of work or nameEnglishQ1860
P1104number of pages11
P304page(s)5840-5850
P577publication date1990-12-01
P1433published inJournal of VirologyQ1251128
P1476titleAnalysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1
P478volume64

Reverse relations

cites work (P2860)
Q33792878A group of V3 sequences from human immunodeficiency virus type 1 subtype E non-syncytium-inducing, CCR5-using variants are resistant to positive selection pressure
Q35729054Absence of HIV-1 evolution in the gut-associated lymphoid tissue from patients on combination antiviral therapy initiated during primary infection.
Q35647691Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID
Q27469352Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: hypervariable region 1 as a decoy
Q27478199Adaptation to Human Populations Is Revealed by Within-Host Polymorphisms in HIV-1 and Hepatitis C Virus
Q41849004Advanced Engineering Strategies for Periodontal Complex Regeneration
Q30378719Advantages of using the QIAshredder instead of restriction digestion to prepare DNA for droplet digital PCR
Q37405780An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family
Q24797088An algorithm for mapping positively selected members of quasispecies-type viruses
Q35839969Analysis of envelope sequence variants suggests multiple mechanisms of mother-to-child transmission of human immunodeficiency virus type 1
Q36656386Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity
Q33782045Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsy
Q36644253Autologous antibody response against the principal neutralizing domain of human immunodeficiency virus type 1 isolated from infected humans
Q36640639B epitopes and selection pressures in feline immunodeficiency virus envelope glycoproteins
Q39451862Broad and potent neutralizing antibody responses elicited in natural HIV-2 infection
Q34539781Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children
Q41978842Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection
Q35704022Compartmentalization of human immunodeficiency virus type 1 between blood monocytes and CD4+ T cells during infection
Q34344788Compartmentalization of surface envelope glycoprotein of human immunodeficiency virus type 1 during acute and chronic infection
Q36796303Concurrent evolution of human immunodeficiency virus type 1 in patients infected from the same source: rate of sequence change and low frequency of inactivating mutations
Q37031589Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient
Q28740329Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy
Q36540055Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing
Q33589350Detection and identification of Leishmania DNA within naturally infected sand flies by seminested PCR on minicircle kinetoplastic DNA
Q37064067Detection of parvovirus B19 in donated blood: a model system for screening by polymerase chain reaction
Q37146859Development of a quasispecies of human immunodeficiency virus type 1 in vivo
Q22248077Development of vivo of genetic variability of simian immunodeficiency virus
Q35127334Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1.
Q40113553Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo: implications for models of HIV pathogenesis.
Q35886136Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses
Q54974242Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver.
Q37145307Elevated hypermutation levels in HIV-1 natural viral suppressors
Q28482493Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing
Q33840365Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies.
Q33645838Evolution and biological characterization of human immunodeficiency virus type 1 subtype E gp120 V3 sequences following horizontal and vertical virus transmission in a single family.
Q39304416Evolution in a chronic RNA virus infection: selection on HTLV-I tax protein differs between healthy carriers and patients with tropical spastic paraparesis.
Q33823310Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy.
Q33784321Evolution of syncytium-inducing and non-syncytium-inducing biological virus clones in relation to replication kinetics during the course of human immunodeficiency virus type 1 infection.
Q33676640Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse model
Q40040768Evolution of the human immunodeficiency virus type 2 envelope gene in preimmunized and persistently infected rhesus macaques
Q45777616Extensive sequence variation of feline immunodeficiency virus env genes in isolates from naturally infected cats
Q36081789Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
Q36631349Genetic analysis of human immunodeficiency virus type 1 and 2 (HIV-1 and HIV-2) mixed infections in India reveals a recent spread of HIV-1 and HIV-2 from a single ancestor for each of these viruses
Q40024166Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy
Q36656211Genetic differences accounting for evolution and pathogenicity of simian immunodeficiency virus from a sooty mangabey monkey after cross-species transmission to a pig-tailed macaque
Q33785632Genetically related human immunodeficiency virus type 1 in three adults of a family with no identified risk factor for intrafamilial transmission
Q33899080Genotypic tropism testing by massively parallel sequencing: qualitative and quantitative analysis
Q35839936Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.
Q30390022HIV - 1 SUBTYPES, ITS IMPLICATIONS AND VIRAL DYNAMICS.
Q93888964HIV colonizing peripheral blood monocytes follows lymphocytic isolates in shifting from NSI to SI genotype
Q47548221HIV evolution and diversity in ART-treated patients
Q33680752HIV-1 Populations in Semen Arise through Multiple Mechanisms
Q34701719HIV-1-induced AIDS in monkeys
Q35852493Heteroduplex mobility assay and phylogenetic analysis of V3 region sequences of human immunodeficiency virus type 1 isolates from Gulu, northern Uganda. The Italian-Ugandan Cooperation AIDS Program.
Q39483634High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease.
Q35940070High throughput functional analysis of HIV-1 env genes without cloning
Q36491810High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems
Q39878854Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo
Q37743275Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strains
Q36690524Human immunodeficiency virus type 1 envelope gene structure and diversity in vivo and after cocultivation in vitro
Q36636446Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.
Q35875709Human immunodeficiency virus type 1 genetic evolution in children with different rates of development of disease
Q33782102Human immunodeficiency virus type 1 populations in blood and semen
Q29619510Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Q33850041Identification of shared populations of human immunodeficiency virus type 1 infecting microglia and tissue macrophages outside the central nervous system.
Q30425937Identification of single and dual infections with distinct subtypes of human immunodeficiency virus type 1 by using restriction fragment length polymorphism analysis
Q36631497Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns
Q45056043Immunological reactivity of a human immunodeficiency virus type I derived peptide representing a consensus sequence of the GP120 major neutralizing region V3
Q36635367In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop.
Q39872035In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates.
Q40106450Independent fluctuation of human immunodeficiency virus type 1 rev and gp41 quasispecies in vivo
Q36649929Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo
Q33839196Infection of the CD45RA+ (naive) subset of peripheral CD8+ lymphocytes by human immunodeficiency virus type 1 in vivo
Q37302765Inferring viral population structures using heteroduplex mobility and DNA sequence analyses
Q35076953Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors
Q35874055Intrapatient sequence variation of the gag gene of human immunodeficiency virus type 1 plasma virions
Q37666746Lessons in AIDS vaccine development learned from studies of equine infectious, anemia virus infection and immunity
Q37257457Longitudinal analysis of intra-host simian immunodeficiency virus recombination in varied tissues of the rhesus macaque model for neuroAIDS.
Q37273086Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.
Q22241902Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission
Q42928634Major coexisting human immunodeficiency virus type 1 env gene subpopulations in the peripheral blood are produced by cells with similar turnover rates and show little evidence of genetic compartmentalization
Q37683012Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china
Q36532973Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones
Q36655707Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins
Q36687307Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS
Q39596106Mosaic structure of the human immunodeficiency virus type 1 genome infecting lymphoid cells and the brain: evidence for frequent in vivo recombination events in the evolution of regional populations.
Q33592278Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis
Q33369086Net positive charge of HIV-1 CRF01_AE V3 sequence regulates viral sensitivity to humoral immunity
Q36549092Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony
Q35652703Ongoing HIV Transmission and the HIV Care Continuum in North Carolina
Q40723808Pathogen evolution within host individuals as a primary cause of senescence
Q37537734Pattern of gp120 sequence divergence linked to a lack of clinical progression in human immunodeficiency virus type 1 infection
Q94570371Pervasive and non-random recombination in near full-length HIV genomes from Uganda
Q36697652Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule
Q30404569Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants
Q39543503Position and degree of mismatches and the mobility of DNA heteroduplexes
Q36798199Positive selection and rates of evolution in immunodeficiency viruses from humans and chimpanzees
Q37145228Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants
Q43449921Rates of amino acid change in the envelope protein correlate with pathogenicity of primate lentiviruses
Q40106668Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity
Q33803939Reevaluation of amino acid variability of the human immunodeficiency virus type 1 gp120 envelope glycoprotein and prediction of new discontinuous epitopes
Q35828735Relationship between the V3 loop and the phenotypes of human immunodeficiency virus type 1 (HIV-1) isolates from children perinatally infected with HIV-1.
Q34120265Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice
Q37612507Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness
Q35159523Robust genital gag-specific CD8+ T-cell responses in mice upon intramuscular immunization with simian adenoviral vectors expressing HIV-1-gag.
Q35558621Role of donor genital tract HIV-1 diversity in the transmission bottleneck
Q33819390Search for the mechanism of genetic variation in the pro gene of human immunodeficiency virus.
Q36647820Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection
Q42596257Sequence comparison of the non-structural genes of four different types of Aleutian mink disease parvovirus indicates an unusual degree of variability.
Q36642795Simian immunodeficiency viruses from central and western Africa: evidence for a new species-specific lentivirus in tantalus monkeys.
Q36520698Simple determination of human immunodeficiency virus type 1 syncytium-inducing V3 genotype by PCR.
Q35879784Size variation within the second hypervariable region of the surface envelope gene of the bovine lentivirus BIV in experimentally and naturally infected cattle.
Q35895520Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS
Q34280044Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop
Q36820549Structure and genetic variability of envelope glycoproteins of two antigenic variants of caprine arthritis-encephalitis lentivirus
Q36634149The "V3" domain is a determinant of simian immunodeficiency virus cell tropism.
Q37386398The efficiency of single genome amplification and sequencing is improved by quantitation and use of a bioinformatics tool
Q33793050The explosive human immunodeficiency virus type 1 epidemic among injecting drug users of Kathmandu, Nepal, is caused by a subtype C virus of restricted genetic diversity
Q35140408The genetic bottleneck in vertical transmission of subtype C HIV-1 is not driven by selection of especially neutralization-resistant virus from the maternal viral population
Q37099851The human immunodeficiency virus type 1 envelope spike of primary viruses can suppress antibody access to variable regions
Q40422860The use of uracil-N-glycosylase in the preparation of PCR products for direct sequencing.
Q35914315Tracking the Emergence of Host-Specific Simian Immunodeficiency Virus env and nef Populations Reveals nef Early Adaptation and Convergent Evolution in Brain of Naturally Progressing Rhesus Macaques
Q37333789Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain
Q35020053Turnover of env variable region 1 and 2 genotypes in subjects with late-stage human immunodeficiency virus type 1 infection
Q40047131V3 loop of the human immunodeficiency virus type 1 Env protein: interpreting sequence variability.
Q36829102Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS.

Search more.