Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain

scientific article published on 4 April 2013

Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKT213
P8608Fatcat IDrelease_35arcklfvra3lck73wctnp2uru
P932PMC publication ID3643609
P698PubMed publication ID23558747
P5875ResearchGate publication ID236114015

P50authorManel EstellerQ3816008
Michael J. HendzelQ42407069
P2093author name stringJuan Ausió
Brad Williamson
Marlee K Ng
Kristal Missiaen
David McPhee
Alexia Martinez de Paz
David P Stuss
Joel D Cosman
Kerry Delaney
Manjinder Cheema
P2860cites workIdentification and characterization of a family of mammalian methyl-CpG binding proteinsQ22003967
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2Q22337290
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in miceQ24568049
Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNAQ24629535
Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domainQ24814601
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylationQ28177120
Intrinsically disordered proteinQ28191444
Molecular genetics of Rett syndrome: when DNA methylation goes unrecognizedQ28240924
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNAQ28265233
SPKK, a new nucleic acid-binding unit of protein found in histoneQ28339810
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndromeQ28504458
Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturationQ28509347
Components of the DNA methylation system of chromatin control are RNA-binding proteinsQ28509434
The major form of MeCP2 has a novel N-terminus generated by alternative splicingQ28511496
MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisionsQ28511729
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatinQ28576622
Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivoQ28591033
The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cellsQ28941207
Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFPQ29547505
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesisQ29547538
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndromeQ46146028
A rodent model of protein turnover used to design an experiment for measuring the rates of channeling, recycling and protein synthesisQ46320924
Comparison of turnover rates of proteins of the brain, liver and kidney in mouse in vivo following long term labelingQ48393340
MeCP2 post-translational regulation through PEST domains: two novel hypotheses: potential relevance and implications for Rett syndromeQ50341204
Presence of a highly specific histone H1-like protein in the chromatin of the sperm of the bivalve mollusksQ67590874
Preferential binding of histone H1 to four-way helical junction DNAQ70500424
Dynamics and equilibria of nucleosomes at elevated ionic strengthQ71300679
Importance of fixation in immunohistochemistry: use of formaldehyde solutions at variable pH for the localization of tyrosine hydroxylaseQ72641619
Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNAQ73893290
Characterization of the stability and folding of H2A.Z chromatin particles: implications for transcriptional activationQ74499946
The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNAQ77828158
MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndromeQ80693217
Beyond the Xi: macroH2A chromatin distribution and post-translational modification in an avian systemQ81414585
H2A.Z stabilizes chromatin in a way that is dependent on core histone acetylationQ83364389
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in miceQ29616328
PEST sequences and regulation by proteolysisQ29616394
Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebratesQ30437379
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.Q30438464
Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexesQ30500778
The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding propertiesQ33186320
Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targetsQ33288477
Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysisQ33479558
Unique physical properties and interactions of the domains of methylated DNA binding protein 2.Q33860692
MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sitesQ34178049
MeCP2 mutation results in compartment-specific reductions in dendritic branching and spine density in layer 5 motor cortical neurons of YFP-H miceQ34193020
A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndromeQ34307505
NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motifQ34330444
Real-time PCR for mRNA quantitationQ34439106
Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytesQ34490485
Competition between HMG-I(Y), HMG-1 and histone H1 on four-way junction DNA.Q34634739
MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.Q34988096
Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.Q34988885
Using FRAP and mathematical modeling to determine the in vivo kinetics of nuclear proteins.Q35051219
Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.Q35114553
Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 researchQ35838075
MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brainQ35888788
Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulationQ36155083
DNA methylation specifies chromosomal localization of MeCP2.Q36556949
The role of MeCP2 in the brain.Q37896649
Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2.Q38303577
Nucleosomes protect DNA from DNA methylation in vivo and in vitro.Q38319446
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and functionQ39461991
Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissuesQ40089440
Cooperative interaction of histone H1 with DNA.Q40561509
The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domainsQ41860564
Nucleosome linker DNA contacts and induces specific folding of the intrinsically disordered H1 carboxyl-terminal domainQ42111436
Coil-to-helix transitions in intrinsically disordered methyl CpG binding protein 2 and its isolated domainsQ42202391
Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.Q42952032
MeCP2 preferentially binds to methylated linker DNA in the absence of the terminal tail of histone H3 and independently of histone acetylationQ43863138
Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neuronsQ43880632
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networksQ46083730
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)4888-4900
P577publication date2013-04-04
P1433published inNucleic Acids ResearchQ135122
P1476titleImpaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain
P478volume41

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cites work (P2860)
Q36094434A high-resolution imaging approach to investigate chromatin architecture in complex tissues
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Q58580302Genomic mosaicism in the pathogenesis and inheritance of a Rett syndrome cohort
Q35489376Genotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett syndrome model mice
Q38853829MECP2, a multi-talented modulator of chromatin architecture
Q50302685MeCP2 Binding Cooperativity Inhibits DNA Modification-Specific Recognition.
Q26747013MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction
Q50993055MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.
Q37632847MeCP2-Related Diseases and Animal Models
Q38451083Methyl-CpG-binding domain proteins: readers of the epigenome
Q40036997Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands.
Q38194967Rett syndrome and MeCP2.
Q47718746Stem Cell Technology for (Epi)genetic Brain Disorders.
Q47445768Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity
Q38307079Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity

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