Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors

scientific article published on 30 January 2013

Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12672-013-0134-1
P8608Fatcat IDrelease_57hobsv6qngkvhwpyt7ptoxovm
P932PMC publication ID3644020
P698PubMed publication ID23361940

P50authorElectron KebebewQ88461842
Martha QuezadoQ110348734
P2093author name stringLisa Zhang
Meenu Jain
Stephanie Barak
Allison B Weisbrod
P2860cites workPML nuclear bodiesQ22065791
Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin associationQ22253267
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodiesQ24319767
Classification and pathology of gastroenteropancreatic neuroendocrine neoplasmsQ26853361
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ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndromeQ27670417
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Daxx: death or survival protein?Q28291053
RNAi-mediated pathways in the nucleusQ28300961
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumorsQ28303693
Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRXQ28505387
ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brainQ28512087
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
P53 transformation-related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non-transformed fibroblastsQ33933630
Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreasQ57767637
Increased expression of mutant forms of p53 oncogene in primary lung cancerQ58212568
Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine tumors (PNETs)Q58417136
Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free dietQ59487959
Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumorsQ60609612
Immunohistochemical localization of chromogranins A and B and secretogranin II in normal, hyperplastic and neoplastic prostateQ71625847
Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasmsQ74250330
Chromogranin A in human neuroendocrine tumors: an immunohistochemical study with region-specific antibodiesQ77102007
Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cellsQ78834996
WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumorsQ80146356
Cleaved caspase-3 immunocytochemical staining for pancreatic islets and pancreatic endocrine tumors: A potential marker for biological malignancyQ82567100
Von Hippel Lindau syndromeQ34129844
Altered telomeres in tumors with ATRX and DAXX mutationsQ34196696
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Assessing TP53 status in human tumours to evaluate clinical outcomeQ34570100
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathwayQ34887795
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulationQ35089377
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumorsQ35681234
Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cellsQ35745875
TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system.Q35837124
The positive regulation of p53 by the tumor suppressor VHL.Q36592019
Chromogranins A and B and secretogranin II: evolutionary and functional aspectsQ37001666
Calcium signalling and cancer cell growth.Q37056451
The nuclear affairs of PTEN.Q37063858
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusionQ37142419
Von Hippel-Lindau (VHL) disease: an update on the clinico-pathologic and genetic aspectsQ37147041
Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome.Q37270416
Granins and granin-related peptides in neuroendocrine tumoursQ37704780
Chromogranin A--biological function and clinical utility in neuro endocrine tumor diseaseQ37706151
The role of PML in the nervous systemQ37821367
Well-differentiated pancreatic neuroendocrine tumors: from genetics to therapyQ37981893
Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cellsQ38333497
Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coliQ38488165
Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.Q39704965
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinomaQ39844741
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosisQ40372916
Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesisQ40647696
Cancer therapy and p53.Q40938367
Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transportQ41694667
Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumorsQ43008626
Loss of PTEN expression in neuroendocrine pancreatic tumorsQ43887224
A Functional Interaction between Chromogranin B and the Inositol 1,4,5-Trisphosphate Receptor/Ca2+ ChannelQ44594114
Modulation of Prostate Carcinoma Cell Growth and Apoptosis by Chromogranin AQ44610279
Argyrophilia and chromogranin A and B immunostaining in patients with sporadic medullary thyroid carcinoma. A critical appraisal of their prognostic utilityQ47843188
Chromogranin A and B and secretogranin II in prostatic adenocarcinomas: neuroendocrine expression in patients untreated and treated with androgen deprivation therapy.Q53437252
Selective processing of chromogranin A in the different islet cells in human pancreas.Q53775188
Daxx is required for stress-induced cell death and JNK activation.Q53851366
Infrequent alteration of p53 pathway in metastatic renal cell carcinoma.Q54105033
VHL mutations and dysregulation of pVHL- and PTEN-controlled pathways in multilocular cystic renal cell carcinoma.Q54627123
Von Hippel Lindau SyndromeQ56068021
Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patientsQ57425794
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)165-175
P577publication date2013-01-30
P1433published inHormones and CancerQ15716573
P1476titleAltered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors
P478volume4

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