Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats

scientific article published on 12 August 2015

Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2015.08.012
P932PMC publication ID4841448
P698PubMed publication ID26277341

P2093author name stringYi Zhang
Fang Yuan
Jing-Jing Zhou
De-Pei Li
P2860cites workCellular mechanisms of orexin actions on paraventricular nucleus neurones in rat hypothalamusQ44249839
Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C.Q44516260
Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptorsQ44538268
Orexins cause depolarization via nonselective cationic and K+ channels in isolated locus coeruleus neuronsQ45185386
Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neuronsQ45244950
Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese miceQ45356742
Antagonism of orexin receptors significantly lowers blood pressure in spontaneously hypertensive rats.Q46072560
Orexin A regulates cardiovascular responses in stress-induced hypertensive rats.Q46982228
Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertensionQ48268840
Distribution of orexin receptor mRNA in the rat brainQ48347303
Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductancesQ48377109
Role of gamma-aminobutyric acid (GABA)A and GABAB receptors in paraventricular nucleus in control of sympathetic vasomotor tone in hypertensionQ48384431
Excitatory action of hypocretin/orexin on neurons of the central medial amygdalaQ48415327
The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglionQ48448082
Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance.Q48526183
Impairment of sympathetic baroreceptor reflexes in obese Zucker ratsQ48572706
Differential expression of orexin receptors 1 and 2 in the rat brainQ48693654
Orexin A immunoreactivity and preproorexin mRNA in the brain of Zucker and WKY ratsQ48701531
Orexin depolarizes rat hypothalamic paraventricular nucleus neuronsQ48792070
Hypothalamic Integration: Organization of the Paraventricular and Supraoptic NucleiQ48857540
Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord.Q50507994
Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activityQ71853624
Renal sympathetic nerve activity is increased in obese Zucker ratsQ72166780
Sympathetic and cardiovascular actions of orexins in conscious ratsQ73279189
Exaggerated cardiovascular stress responses and impaired beta-adrenergic-mediated pressor recovery in obese Zucker ratsQ79249932
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorQ24315738
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activityQ24317782
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunctionQ24322907
Development of attenuated baroreflexes in obese Zucker rats coincides with impaired activation of nucleus tractus solitariusQ33568792
Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob miceQ34112881
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systemsQ34854732
Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflexQ36147335
The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injuryQ36737230
Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive ratsQ36844614
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivityQ37071459
Leptin resistance and diet-induced obesity: central and peripheral actions of leptin.Q38286537
Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker ratsQ38297699
Orexin A activates leptin-responsive neurons in the arcuate nucleusQ38308032
Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cordQ40817896
Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker ratsQ42482589
Protein distribution of the orexin-2 receptor in the rat central nervous systemQ42516895
Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive ratsQ42524224
Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions.Q42527611
Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptorsQ43056332
Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflexQ43708499
Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor toneQ43888061
P921main subjectobesityQ12174
P304page(s)481-490
P577publication date2015-08-12
P1433published inNeuropharmacologyQ15332439
P1476titleUpregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats
P478volume99

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cites work (P2860)
Q39138292Acute stress diminishes M-current contributing to elevated activity of hypothalamic-pituitary-adrenal axis
Q92480791Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats
Q42516144CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension
Q92856879Downregulation of Orexin Receptor in Hypothalamic Paraventricular Nucleus Decreases Blood Pressure in Obese Zucker Rats
Q55330079Expression of Proinflammatory Cytokines Is Upregulated in the Hypothalamic Paraventricular Nucleus of Dahl Salt-Sensitive Hypertensive Rats.
Q90108160Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension
Q39309534Implicating the potential role of orexin in hypertension
Q45062430Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension
Q50222692Orexin A increases sympathetic nerve activity through promoting expression of proinflammatory cytokines in Sprague Dawley rats
Q64118688Orexin Receptor-1 in the Rostral Ventrolateral Medulla Mediates the Antihypertensive Effects of Electroacupuncture
Q39421016Polyunsaturated fatty acids and endocannabinoids in health and disease.
Q90251339Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
Q39206265Role of Orexin-A in Hypertension and Obesity
Q38649785Sex-specific differences in cardiovascular and metabolic hormones with integrated signalling in the paraventricular nucleus of the hypothalamus
Q39204098The Orexin System and Hypertension
Q57792078The α2δ-1-NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory
Q100446558Unilateral section of the Superior Ovarian Nerve induces first ovulation in the Zucker fatty (fa/fa) rat

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